Conserved Protein Domain Family
CCDC24

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pfam15669: CCDC24 
Coiled-coil domain-containing protein 24 family
This family of proteins is found in eukaryotes. Proteins in this family are typically between 187 and 319 amino acids in length. There are two completely conserved residues (G and P) that may be functionally important.
Statistics
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PSSM-Id: 317972
View PSSM: pfam15669
Aligned: 23 rows
Threshold Bit Score: 141.298
Threshold Setting Gi: 291000985
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82178413   23 LPEIRAVLGDALIDTYTELYSEVEMWEKIWQELHfseRGS-RPE------A---------PVFPLADPPALKELLKAEIQ 86
gi 198433817  30 LPVIHSYLGESTIEYCKDLRNEMETLLEIWRDIGd-rTEM-PTV------Sk-------pLSNPLPDPPIMREMLKKEIQ 94
gi 156396644  36 RPEIKEVLGEDLVEETVELHNEATSLLEIWREYHe-eTDR-EER------Eval----nrHLSRLPEPPLIRENLKKEIM 103
gi 196011176  28 iDEITSIIGRSLTQQVEEIRQEAGYLLDIWRDLRq-qTDS-LVA------En--------PTKLLPEPPELRNRLKQEIT 91
gi 762098925  29 hEEIKGMLGESLVDQSLELRTEIDTLLDIWRDYRd-eT------------Ne-------nCKEKLPEPPGLRDRLVQEIQ 88
gi 260832976  36 LEEVKGILGTTLVEQCMDLHAEVRTLLEIWQDYRd-dTDQ-LIQrgsggrSg-------lRSGQLPEPPRQRELIVDEIK 106
gi 340373261  34 aNEVKRAIGQSLIEEACDLHTEASLLLEIWRQMRe-eADPgRPH------Dg-------dTPARLADPPGVRDKLIQEIK 99
gi 302852317  34 RDEIRRALGTALLDDNETLFAEAGALADILGDVTl-nTSA-Ll-----------------ARHQLCSNP-QRSMVETEIR 93
gi 255074777  39 vDEVRRALGSSAIDENDQLMMEADALAEIIGDVRq-rTDA-TAH-----------------ARRLYDNPR-RALIEGELR 98
gi 676389557  17 LPELARAVGEERMEKCGDLRAEADALREIVEGYAs-eNAA-PLD------DgadaarrsaSGALLLSGGPERDMLERKIA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82178413   87 LLLLTL-----------------------REKAAR--------------------------------QGRDEEEVISQ-Y 110
gi 198433817  95 ILVKGV-----------------------QDRHTV--------------------------------SG---DQTLNE-- 114
gi 156396644 104 MFVGML-----------------------QQRAEE--------------------------------EGRQSSSVLSK-K 127
gi 196011176  92 MLLDIL-----------------------KQKD-----------------------------------DMAHKQDMLQ-D 112
gi 762098925  89 FFLENV-----------------------KEKSRL--------------------------------QGLNPERILATgH 113
gi 260832976 107 FLLQNL-----------------------KERANS--------------------------------EGRNVQDLLSK-H 130
gi 340373261 100 FLVSYL-----------------------QQ--------------------------------------RNSTSPVVR-E 117
gi 302852317  94 LLIERL-----------------------HASAAVspfg------------------------ssavKDRDPDSLLPR-H 125
gi 255074777  99 LLVQSIkrcasgdyaeasgrpgstgsassQEREIRwqdigsgtandpmvearreererglrtadpaaAKRAERLMAGDsR 178
gi 676389557  89 MLLDYL--------------------------------------------------------------GEQGEAPSAE-K 105
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82178413  111 ---SPSVVSY-------ALgntkrqrspG---------------------------------TWRE-RKSP---SRPPS- 142
gi 198433817 115 ---EKDVLKY-------VV---------Q---------------------------------SQHL-QQSF---ERPST- 137
gi 156396644 128 ---DNEIVDY-------VMerp----eaT---------------------------------VKRC-RSAS---SRPST- 155
gi 196011176 113 ---YKHIVSY-------VTq--------P---------------------------------RENQ-VSPL---SRPQS- 136
gi 762098925 114 ---NTTVLDY-------AM---------D---------------------------------VSRPgTARG---SRPST- 137
gi 260832976 131 ---NPGVIQY-------AL---------T---------------------------------DKAT-GSRPgtgSRPSTs 157
gi 340373261 118 t-lKSPVITY-------VQ---------N---------------------------------TEEH-RSSC---SRPST- 142
gi 302852317 126 gkrDRAVLDY-------MT---------TvaqvagpegrgrvctlywsqfirsalsasnvsaSISL-PSPL---SRPGT- 184
gi 255074777 179 ---ERKMLDY-------VTgvad-aaaiR---------------------------------AGTP-RTPP---SRPAS- 209
gi 676389557 106 ---DARVRRYlaskradAE---------P---------------------------------EARE-SSPS---KAPRS- 135
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82178413  143 ----------------------SLSEtgs---------rsvSS-----------F---------------SSHSSCEEEI 165
gi 198433817 138 ----------------------PIRHy--------------TS-----------E---------------TSYTTSPVKL 155
gi 156396644 156 ----------------------AASSqdgrqtp-mratpssEG-----------S---------------RCTSSLSDHL 186
gi 196011176 137 ----------------------ACSSldnrevpvvqsscsgRS-----------S---------------AANSMLDDEV 168
gi 762098925 138 ----------------------AMSRegrdtpm-ictptgsDR-----------A---------------SAASTLSEEI 168
gi 260832976 158 gsrpssarsrsgretplrrtatPSSDd--------------DR-----------M---------------SISSGMSDQI 197
gi 340373261 143 ----------------------SSDKs--------------SRycd-----tplA---------------FSNSSSVTGL 166
gi 302852317 185 ----------------------ASPTl--------------QG-----------SrpstaassasassavTRYTDAPSVV 217
gi 255074777 210 ----------------------SSVSr--------------PGtgasagsggssG---------------SALGNPVAAV 238
gi 676389557 136 ----------------------PARPg--------------T------------A---------------DKAPTRRKEV 152
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82178413  166 KALRHKLNITHIDEVVAHLRSVLTEESEALRKDVQAL--------QENLEAERVSTQTEP-V-C-PEPTL 224
gi 198433817 156 KHVRSNINVKDIDKVALILKEAIQKECAALEHDIEFL--------QKCVEEEHDLVASPP-AtPmQEPSL 216
gi 156396644 187 ESMNDKLNALEIDRITDHLRSLLLEEKQRLSDDISFL--------QECLVEESDYRQQVM-AsPdPEPSI 247
gi 196011176 169 KSISDRVNITDIDSIAEALRNLLEEEYESLKGDIEYL--------QSCLEDESSFQHETN-S-IpTEPTL 228
gi 762098925 169 ESMTDKLNYLKFDEVVQHLKEYLEDEISTLLRDIQFL--------YECLDEEAMYRAETQgT-YsREPTI 229
gi 260832976 198 DRLQDNLNVSRIDQVVEHLRQTLEQECSVLTQDIAFL--------QAKAQHDEEFRLKTI-P-NaPltsd 257
gi 340373261 167 LESTSSLSIQDVDESIASMRNTVREEIDQRHRDIDLL--------QSYIDSELSYQKQPIptikdlqsvs 228
gi 302852317 218 AGLADKLNVASIDTVRETLRTALLEERTALLEDVEYL--------QGLLDVEADLQVR---A-TvPPPSL 275
gi 255074777 239 EQFGGKINAFDVDKVAVPLKELLAEERAALLDDVEYL--------QTCLEDEADRGKRVE-A-PaPEvee 298
gi 676389557 153 EALRKSLNVETFDEVLAEVRSLLDAEAEDLLREIDDLtatfdrvdEAVVERAQGGAPRPS-DgApAPPSL 221
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