Conserved Protein Domain Family
SPICE

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pfam15678: SPICE 
Centriole duplication and mitotic chromosome congression
SPICE is a family of proteins found in chordates. It localizes to spindle microtubules in mitosis and to centrioles throughout the cell cycle. Deletion of SPICE compromises the architecture of spindles, the integrity of the spindle pole and the process of aligning chromosomes on the spindle (chromosome congression).
Statistics
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PSSM-Id: 317981
View PSSM: pfam15678
Aligned: 18 rows
Threshold Bit Score: 213.445
Threshold Setting Gi: 167527436
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883387   33 NTVNDLTVHRATPEDLVRRHEMHKSKNRALVHWELQEKALKRKW-------KKQKPETSS-IEKRKLSIMKEILSDQYQT 104
gi 637352872  33 STIHDLSVLRATPEDIAIRHEMHKSKNRALAHLELQEKSLENTR-------NKLRPRAPQsVEKKKLDLMRAIISDQYQL 105
gi 765154300  33 STVHDLSVHKPTPAELTHRHEIHKSRNKAVAQWELKEKALKRCA-------R--QAGSPApLDPASLSIIREVFSDQLLL 103
gi 260823786  34 DTTSDLSVHKATDEEIKHRHEVHQSKNLDVIRLENQKMMIQKDScfnyiciARARPKTPStVEKRKAALLREVLYDHS-- 111
gi 156404071  45 STVNDLNVYKASEDEVRQRHEAHKSKNYGLPRKQATNK-----E-------NSPGYITTPnSAQRKQAILQEILYGRDQF 112
gi 167527436  16 DTVHDLSEHKLSSAALRRRKEAHASRHANQAKQLLQA---QRRR-------NLAQPQTPPqPHTPTTGVFRLLKAFRMHG 85
gi 823453292  30 sTVHDLTVHRATPEDILRRREIHKSKNKALAHVELQEKALNRKW-------KKQRQVDADsLEKRKLALMREILSDQHHW 102
gi 847098682  34 STVSDLTVLRATNEELEHRREIHRSKNQWLARWELQNKATNKKS-------EKENGGYSAlLENSRLALMKEILSDQYLM 106
gi 941775696  33 STVNDLSVHKLSPAELCHRHEIHKSHNKAAAHWELREKALKRRL-------R--HAGSSPgLDHTSLTIIRDVFSEQPLL 103
gi 528519725  32 STVNDLSVHKATPEELARRHEMHRSQNRVVAQWELKEKTLTRRR-------RKNQPLSPPgLDRARRDIIREVFSDHCQL 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883387  105 Q-DVLEKSDHLLTAAKG-----LFvd-----------------vpRKRTgfpnv-------------------------- 135
gi 637352872 106 H-DVLEGSDQAMAVVKD-----LFgd-----------------apHWHLgfpnvtv------------------------ 138
gi 765154300 104 Q-DVLARSDRAMAVVKD-----LFgd-----------------apQRQIghpsvtm------------------------ 136
gi 260823786 112 Q-DVLSKSDRVMAVVRD-----LFgd-----------------dpKRYTgfpnvt------------------------- 143
gi 156404071 113 Q-DVLAESDRTMSVVKD-----LFgd-----------------dpKKYMgfpnitv------------------------ 145
gi 167527436  86 ArGVLTHIPSLLSSPRDacdrcLFpraalprrrfvlppnhagqapLRRTlrpgleafedddndvhghddddddldygaed 165
gi 823453292 103 Q-DVLERSGQVIAVAKD-----LLea-----------------apRTRTgfpnvtm------------------------ 135
gi 847098682 107 N-DVLERSDRALAVVKD-----LFgd-----------------apRRHTgfpsvtm------------------------ 139
gi 941775696 104 H-DALAQSDRALAVVKD-----LFgd-----------------apRRQTghpsvtv------------------------ 136
gi 528519725 105 Q-DVIARSDRALAVVKD-----LFgd-----------------apRRRTgfpsitv------------------------ 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883387  136 ------------tmapgS--SRSPAGINQDPGTQ-SILNESIIEPQ--ALNEvddggae-stahsqsE--DS--ESELPN 193
gi 637352872 139 ----------apdhdveS--SEDLIVQKCDLPTQlSILSESVMDPQ--ALNEkeecsf---vcntnsE--GG-------V 192
gi 765154300 137 ----------apncdsdT--EL-PVLERPDPPTHlSFLSQSMMDQE--ALNDlev----------skE--NR--RVE--- 184
gi 260823786 144 -----------kapdnpS--GRGPVIEPPEQPTQlSMLSQSIMDQS--ALNEvdae-------reqgE--AG--E-EQTL 196
gi 156404071 146 ----------ppqvlseNteRNGPIAEVPEAQTQlTQLSESVMQTA--ALNEisedeg----nssgtE--PSpqSNQNQA 207
gi 167527436 166 nyvytadllqsphnrrpR--GGQPVLAARAYRTVvPGTANSSFEEThaAHNDtaaqrqygyhapggaSasPS--ERAVDW 241
gi 823453292 136 ----------apncdleS--SQGPIVQKSHPPSQlSILSESVMDSQ--ALHEeeee--------alaE--DG---HH--- 185
gi 847098682 140 ----------apscdldT--SRAPIVQKKDPPTQlSILSESIMDSQ--AINEvdks-------lspaE--YS--DSEAEV 194
gi 941775696 137 ----------apncdsdS--EL-PVLQRPDPPTQlSLLSQSIMDQE--ALNEvev----------srE--DV---RDEDL 186
gi 528519725 138 ----------apdcdsdS--EL-PVHQKLDPPTQlSLLSQSMMDQQ--ALNElee----------heE--EC--DEVQDA 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883387  194 SL--SPH--SNRNTERflhqlkeenselinqlwtdiqqkiaaqsqrtppgsp-------------sselsaedqkgalna 256
gi 637352872 193 YL--NTR--SNIDTKRvlnllkednsvancqpeaskqhistvsteevdill---------------tpaasfqslehtal 253
gi 765154300 185 ----NTS--SDSHVIHrvtgrksksqsgsgvlrqqkmhhsnfhhadsddgpv---------------tpcasrkppnqna 243
gi 260823786 197 SQ--QFE--SRLDLQRfrrfleqerqqdstlrqqdstlrqqdstlstipgeqqgqqgaatstmlqagtshqvessnpvrt 272
gi 156404071 208 AQrmTFQ--PRLDLQKfkefvsqeqndsgqpsyevknpisasrsqgiprgkvlq----------pavqaedhssflsgts 275
gi 167527436 242 EH--YAQvvSDARERRaeqesqllsslervqawaeksadqiqepnspsrl----------------------tsatlqqq 297
gi 823453292 186 DVl-GFK--SRINSDRllrllrkgnslvnsplwvekdmrkstlsqesnvpct-------------pttvspsldhsalna 249
gi 847098682 195 TI--STQ--PNRKAErgqqllsgegpkneafitpcksggdpsq------------------------------thcalna 240
gi 941775696 187 SS--SSG--SRF--IRrtnirktktqtratqkqkghrlrshagdkenipvt---------------pirsgrapdptaln 245
gi 528519725 189 SV--HLK--SVMH--Rkrnkcrpksfprgsdnheqdlpqkpcttg----------------------------vredyaa 234
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883387  257 tdavkriqaglqpeesaepvdSSY-VGQVl--NTRKPKPLLSKVKRKQDMRALSKQKKNMLSSSTTSA---DLASSNNSS 330
gi 637352872 254 nathvvkkvhsrfqneeqtadTPCtIQQVlnaKVKKQKHTSTKVKKKQTAQTPTGQTRINLNATSASV------NGQNSS 327
gi 765154300 244 lnatvavqrvrskhfeeneeetSSqVSQVlnpEPLLCRS-GRSGSCTRKVRKCVSHGSELDGSTAASL------SGEQSG 316
gi 260823786 273 vnmsqvqptavntqtpvrdvdSTSlTNQAindTAKVTRTRSRAGAADHT----------------------DLSSLSLTK 330
gi 156404071 276 gntilagapnfmfpaqqssgePTAiAEip--gSERLEQAGEVKARVKSNEKAPKLKATVKPAQGPKGL----------RC 343
gi 167527436 298 qaelaaqtqaqdaakalvaqlvserVDQL---ETRLRQALQPGTESPRSTQAPASDPLGATT---------TLAAGTGPS 365
gi 823453292 250 tsvikrthsrlrnedeeesvdSSDtVRQVlnpNSRKQKQIAAKMKRKQAEQNSARQKR---GDSPANLiqtDLQRDSKPS 326
gi 847098682 241 ttavnrvkvrrteeespkpeeSESiIGRVlnpQGKANKRISSKGKKTRSATPSHTKDLSACRESQH-----ELTASNQSS 315
gi 941775696 246 ataavkrfltkqrpsdqneeeASVlVSQVlnpELPSRQS-GRIRKHTEKTRKGVCRALELDGSSVASL------SGDQSS 318
gi 528519725 235 lnatvaveqlksrqthpgvnqSTSfVDQFlnpEPASSQH-GVKNRSVQASRGRSAHTSAMNSSGLHSL------AGNQSS 307
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883387  331 LDVLKhmihevehEMEEYERWT-GREVKGLQ---GGQgltgftlSLVSSlcr---lvRYLKESETQLRKEVETRQQLEQM 403
gi 637352872 328 LEYLNqmlhdlehDIEEYERWM-GHEVQYVH---SREgvsgfthSLVHAlnr---mlHCLKQTETKVRQEIINRQQLERE 400
gi 765154300 317 LGLLQamlgqveaDLDAFCPQMaSAQSLKQH---KTQsltgfsvALVSTlgr---lvHLLRQAGEDTQKETEGRRRLEGE 390
gi 260823786 331 LDELKqvmdnleaEIADYEHQA-GMPTPPPPqqhKSPtlrgyttSLLEAitr---ltRHIKESESQLRSEATLRHHLMEE 406
gi 156404071 344 LDDLKkmvenledEIAEYEMET-GRESSGKTn--QTNsfsgytsALVIAvtk---lmRYLKESEIQRRAEAVIRDQILQG 417
gi 167527436 366 NGTPShnr-----------------------tdvPGTqlhgpmlAILEFmdrlvdgtAQLSTTQAQLGAQQERTAERLNS 422
gi 823453292 327 LDVLShmiqeverELEEYERCT-GREVPKKE---RSEglsgftlSLVNAlcr---lmRYLREAEMQLHEKEMVRQQQKEM 399
gi 847098682 316 LGLLNsmiqeveqDLAEYERQT-GREVISAP---PAHgltgftlSLVSSlkr---vvSYLKESDLLLQREVKERQHLQGE 388
gi 941775696 319 LGLLQdmlgqvkaDLDTMSSDIaPEPTGSPEp-yERQgltgfsvSLVSTigr---lvQLIRKREAEAQEEAEERRRLQED 394
gi 528519725 308 LELLQsmleqvetELDSLDKQN-PQSSETRPq-qQRPgltgfsvALLTTlrr---ltSHIKKRDEESLRETRERRRLEDE 382
                        490       500       510
                 ....*....|....*....|....*....|....
gi 81883387  404 lGDHRELIDA---LTAEILLLREENGAVQARLQQ 434
gi 637352872 401 lSEHRVLIDA---LTAEILLMREENFAMQSTFQr 431
gi 765154300 391 lKEQRGLIDA---LTAETMALREEAAAVQADLQr 421
gi 260823786 407 iAEQRALVDV---LTADIINTQEQYTVLRGEFDQ 437
gi 156404071 418 fAEQRTLIDA---LTNDIVQTQEQNMILQEEMHV 448
gi 167527436 423 lEHAQQATDArleQQHEVLTTLEASLRAHGDARE 456
gi 823453292 400 lNEHRELIDA---LTAEVLQVREENITMQKKLQQ 430
gi 847098682 389 lVEQRLMLDA---LTAEILTLKEGNNIHENHLQT 419
gi 941775696 395 lKEQRGLMDA---LTAETMTLREEGAAMQAGLlq 425
gi 528519725 383 vKEQRALIDA---LTVETLTLREESAALQARLQl 413
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