Conserved Protein Domain Family
TMEM132D_C

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pfam15706: TMEM132D_C 
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.
Statistics
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PSSM-Id: 318007
View PSSM: pfam15706
Aligned: 40 rows
Threshold Bit Score: 75.0505
Threshold Setting Gi: 242022904
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675885346   523 SKFHQTNSNNNNNG--Y--SQHPP-SLHASALTPLEIGMYTLLAVFCLAVFIFIINCAFFMAKHRRkndsnsprknla-s 596
gi 780081199   868 DKAEASTEAPL-DG--G--NDGGL-SDDSDPLSGIEIGMYVLLSVFSLAILAFMVNCVMFMARYRR-------------- 927
gi 688605373   882 lekpnfpfppeepkrepplVESNL-IQMFSVFTDIEVCIYALVGLSCLAMIAVLLHCATSSARTRN-------------- 946
gi 1036764408  875 yeptvqarqhrgsiqavhkghhgkgiggtgtmttmELGMYVLLTAFCFAIIVFVISCVVYASKFRPamiesgldplsa-g 953
gi 242022904   881 NNHEPTVQARQHHS--AliPHSNFhVRNSNRMTPLEIGMYVLLAAFCFAIVVFVVSCVVYASKFKA-------------- 944
gi 926731154    13 EAGKEEAEAREEEEe---eGEEEM-VPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQR-------------- 74
gi 432108900    21 AGQEEEAEAREEEG-----GEEEM-VPAPRRVTNLELGMYALLGIFCLAI-IFLVNRWCLCCTTSA-------------- 79
gi 195045927   936 HRASIQAVHKTHYGnrA--SGFG-----SGNMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPvmiesgldp----- 1003
gi 195174728   882 GSSSIQASHKNHFNgkG--G--------TGTMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPaliesgld------ 945
gi 968067630   921 HRSNIQAVHKSHFGg---kGHGN------GNMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPaliesgldplsavg 991
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 675885346   597 nrklssgipkrK-------------DGTVAAt----------TAAVga------aaNCSPDWVWIGRE 635
gi 780081199   928 -----------A-------------KRMPKT-----------HQPV----------PYPQNWVMFGMQ 950
gi 688605373   947 -----------R-------------KTPIQC-----------QGQH----------EHRHHWVRLSTA 969
gi 1036764408  954 kgngsgasggfR-------------DVRLKE-------------ST----------TNAHDWVWLGRS 985
gi 242022904   945 -----------QvgetvdvsssddnNGANIGvsngnsgykglPQST----------TNVHDWVWLGRA 991
gi 926731154    75 -----------K-------------EPPDGAi----------DPAS----------PQPHNWVWLGTD 98
gi 432108900    80 -----------R-------------SPPNGAl----------DPDS----------PQPYNCMWLGTD 103
gi 195045927  1004 ---ltgagkgnA-------------NGGVGGfrdvr---------------lkestTNAHDWVWLGRS 1040
gi 195174728   946 ---plsmgkgsG-------------GGGGGGi----------SGGGfrdvrlkestTNAHDWVWLGRS 987
gi 968067630   992 kgngngsiggfR-------------DVRLKE-------------ST----------TNAHDWVWLGRS 1023
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