Conserved Protein Domain Family
UNC80

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pfam15778: UNC80 
Cation channel complex component UNC80
UNC80 is a family of proteins found in eukaryotes, and is typically between 193 and 224 amino acids in length. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.
Statistics
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PSSM-Id: 318073
View PSSM: pfam15778
Aligned: 17 rows
Threshold Bit Score: 299.627
Threshold Setting Gi: 260789998
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768959255    16 KGIPFPIQTFLWRQTSAFLRPKLGKQYEA-------SCV----------------SFERVLVENKLHGLSPELSEAIQSI 72
gi 242011032    21 QALPLPIQIFLWRQISPFIRPKLGKLHEA-------SCM----------------SFEKILVQNIQYGLSPSLTDAVSSV 77
gi 241006890    16 LAVPLPIQTFLWRQTSPFIRPKIGKTHDA-------SAM----------------SFEKVLVQNIQFGLSPSLTVAIKSI 72
gi 170055631    18 LGVPVPVQTFLWQQIAPFIRPKLGKLHEA-------SCM----------------SFEKSLVQNMFYGLSPSLEAALKSI 74
gi 827556486    15 EVIPIPVQIFLWRQTTPFVRPRLGKLHDS-------SCMfcqrapghhelkeackSFEKVLVQNLRLGLSSSLTEAIESI 87
gi 321469572    20 DIVPLHIQTFLWRQTSSFLRPKIGKMHEA-------SCI----------------SLEKILVQNIRVGLSPNFTEAIRSI 76
gi 1005948785   14 ESIPLPIQTFLWRQTSPFIRPKFGKQQDAlameqreACK----------------SFEKVLVQNIQFGLSPSLTDAIKSI 77
gi 968074013    16 LGLPVSVQTFLWRQIAPFIRPKLGKLHES-------TCLfcqhapghheskeackSFEKVLVQNIQFGLSPPLTKALGAI 88
gi 1028707188   17 LPVPINLQNFFWGLTSAFIRPKVGKLHEN-------SCLfcqhtaghhemkeackTFERLLVLDSQIDLPEKLKEEIRLL 89
gi 675862204    16 NSIPIPIQTFLWRQTSPFIRQKLAKLCES-------SAL----------------SFERVIVQNILHGLSPSLCEAIQSI 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768959255    73 SRWELVQAALPHVLHCTSILLSNRNKlGHQDKLGVAETKLLHTLHWMLLEAAHEcnhepslghgwsaggsssssaflqpv 152
gi 242011032    78 PRWRLIQAAFPHVMHCTATLLQNRKD-TNMQNLGATESKMLYTLHWILLTAAEE-------------------------- 130
gi 241006890    73 RRWRLVRAALPHVMHCCAALLHARKE-SCLEKLGSAETKLLYTLHWILLDAAEE-------------------------- 125
gi 170055631    75 PRWRLVQAALPHVMHCAGALLHNRVK--DLQALGAVETKMLYTLHWILLFAAEE-------------------------- 126
gi 827556486    88 PRWRLIQAALPHVMHSLASVLHTRVK-DNMQSLGNVETKLLYTLHWILLDASDE-------------------------- 140
gi 321469572    77 SRWKFVQSSLPHVMLCTAQLIERKDT-NNLQNVGTAASKLLYTLHWTLLDAAEE-------------------------- 129
gi 1005948785   78 SRWKLVQASLPHVMHCCSALLYNRKN-SNLDKLGAAETKLLYTLHWIVLDAAEE-------------------------- 130
gi 968074013    89 PRWRLLQGALPHVMHACAALLHNRVK--DMQAIGPVETKLLYTMQWILLYAAEE-------------------------- 140
gi 1028707188   90 PRWNIIQASFPHILHSTAAILQNRKG-TNIQYIGPIESKLLLILHWIIQDAPDE-------------------------- 142
gi 675862204    73 SRWKFVCASFPHVIHCCASILLKRLEtNPEAKFSTSDIKLLYTLHWIILDAAGE-------------------------- 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768959255   153 gnqgsspgaplgsCAG---------SsalggsgpqhgssllEEDENARAKl---FNKSMATVELFVFLFAPLIHRIKESD 220
gi 242011032   131 -------------CAD---------A---------------DHENGIFQSspfyYLFSIPAITLFIYLFAPIYHHLKESD 173
gi 241006890   126 -------------CSD---------A---------------EHAGGPDpa---rYVFPISVIQVFVYLFAPLIPFLKQSD 165
gi 170055631   127 -------------CAD---------D---------------DLEANKDVKrhqsYLFSIPTISLFVYLFAPIAHLLKESD 169
gi 827556486   141 -------------CAD---------N---------------DYENGVFYSnpfhYLFSVPTMTLFVFLFAPLSHHLKESD 183
gi 321469572   130 -------------CAD---------A---------------DREAGIAPRepfpYIFPLTCIQEFVYLFAPLRHLLKEAD 172
gi 1005948785  131 -------------CAD---------A---------------EIEQGIN-RpidhYLLPITTIELFVYLFSPLISYLKNSD 172
gi 968074013   141 -------------CADdesgedlglG---------------DALPEPKSKpidqYLFSVPTITLFVYLFAPIIHHLKESD 192
gi 1028707188  143 -------------CAD---------S---------------DYEKGTFQTlphyYLFNIPTMTLFIYLIAPLINQVKESD 185
gi 675862204   127 -------------CED-------------------------NEPKKSFKTvkcsYLHSLDTIQLFVFLLIPLVSSLTRSD 168
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 768959255   221 L--N-FRLASGLVIWQPMWEHRQPDIPAFTLLIKPI 253
gi 242011032   174 Fq-T-YRLENGLKMWQALWDYKHPDIPCFTAHVKPK 207
gi 241006890   166 FvgS-FRLENG-----PLWEFRHPSVPCFTAPVQPH 195
gi 170055631   170 Fq-N-IRLENGLKMWQGMWEYRAPNASCFIAPVKPK 203
gi 827556486   184 FtnN-YRLENGLKMWQAMWEFRHPDAPCFTTLVKPK 218
gi 321469572   173 Lq-N-FRLENGLKIWPALWDYRHPNAQCFTAPVRPK 206
gi 1005948785  173 Fl-TsFRLENGHKLWGPLFDYQHPDIPSFVAQVKPR 207
gi 968074013   193 Fq-N-FRLENGIKLWQGMWDNRAPGAPCFTAPVKPK 226
gi 1028707188  186 Li-S-NGLESGLKMWQAFWDNRTPAIACFSAHCKPK 219
gi 675862204   169 Fd-N-LKLENGLRLWEPLWHYQQPNVYCFSTPVK-- 200
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