Conserved Protein Domain Family
GPS2_interact

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pfam15784: GPS2_interact 
G-protein pathway suppressor 2-interacting domain
GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.
Statistics
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PSSM-Id: 318079
View PSSM: pfam15784
Aligned: 12 rows
Threshold Bit Score: 95.6435
Threshold Setting Gi: 1040099808
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005971289   12 YPGVEAISPA-LPSEESQPDYSSTFRTSKDELLQNIDKIDREISQTETQISELKERKKQLELKAVSRDsvkDV---RENV 87
gi 947211230   141 TGKLEPVSPP-SPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPP---EP---EKPV 213
gi 1032759055  338 TPQTEAISPT-LPEPNT--QEDTVFKITKDDLLQQIAKVDREIAKRESQISKLRKKVKEIEEVASKPL---EApgtKRPV 411
gi 357631774   260 NNSVEVLSPN-PPSEPT--VEDQSFRTTKDDLLQQISKVDREMALSEQTLLKLKKKQEELEQSASKPA---------RAE 327
gi 780126041   178 MPKVENISPT-------PCDQETTNKISKEGLISSMDKVDREIAKVESQISKLKKKQQELEQRAARPI---DT---DKPL 244
gi 405953548   242 NPQVEAISPT-LPPDETSP-------SSKDQLLQAISKVDREISKVDKDIQKLKKKQEQLELEKCKPP---EE---KQKV 307
gi 752884064   134 TPQTEAISPT-LPEPNTQEDAL---RSTKDELLQQIGKVDREIAKRENQLNMLRKRIKELEEAANKPL---EAtglKRNI 206
gi 827552749    97 YNTVEVLSPN-PPSETS--GEDQTLRTTKDVLLKQISKVDREMALVETSLAKLKRKQEELQQSASKPA---------RAE 164
gi 939687002   192 NPQVEAISPT-LPSEA--LQEDANFRSTKDDLLHGIAKVDREITKTELQISKLKRKQQELEEAAKKPA--------IKKE 260
gi 1040099808   51 GGKHEAPSSPlAGQPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPP---EP---EKPV 124
gi 768938647   143 TVKVESLSPGgHTLHIGEDQDTSPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPM---EP---EKPV 216
gi 332649638    88 iGKIEPISPV-SPVPMEADLDLVPSRLSKEELIQNMDRVDREITMVEQQISKLRKKQQQLEEEAAKPQ---EP---ERTI 160
                           90
                   ....*....|....*.
gi 1005971289   88 DNS--S-ETRQLSIAQ 100
gi 947211230   214 SPPp-I-ESKHRSLVQ 227
gi 1032759055  412 EEAs-S-QPKHQSLVQ 425
gi 357631774   328 EPEe-A-PPRHRSLAQ 341
gi 780126041   245 SPAfgS-EPKQQNIIQ 259
gi 405953548   308 KDIv-VtETKHQSIAQ 322
gi 752884064   207 EEQs-Q-QPKHQSLAQ 220
gi 827552749   165 EPEe-A-PSRHRSLAQ 178
gi 939687002   261 EEEv-P-QPKHQSPAQ 274
gi 1040099808  125 SPPp-V-EQKHRSIVQ 138
gi 768938647   217 TPPp-V-EHKHRSIVQ 230
gi 332649638   161 SPPp-S-EAKHRSLVQ 174
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