Conserved Protein Domain Family
LAS2

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pfam15792: LAS2 
Lung adenoma susceptibility protein 2
LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumorigenesis.
Statistics
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PSSM-Id: 318086
View PSSM: pfam15792
Aligned: 20 rows
Threshold Bit Score: 44.8257
Threshold Setting Gi: 1033366811
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620603   161 SLDIKDSP--------------SF--------YAPKSKDNtLPPYVYTNINGKKC----GDKIELLILKAKKNLKQSTED 214
gi 73620602   161 SSDIKNSP--------------SFyv-----dATSKSKNNiVPPYVYTNINGKKCg---RPRTPKPINRENKCVSESSLS 218
gi 625221283  162 SSDIKKKP--------------NFhi-----dSTPKSKDNvVTCDVYSNVNGKKCg---RPGTLKPVNRNNKRVLESSLS 219
gi 780172120  677 SLSSLSSI--------------ALet-----dHLMNGKAA-RPPLIADHVSESTVg--eTARTNAMLRRANRIVDNTQAS 734
gi 397513973  161 SLDIEKNP--------------HFqg-----pYTPVGKDNfVTPVIRSNINGKQC----GDKIELLILKAKRNLEQCTEE 217
gi 431896179  161 SSDTEKRH--------------NFqe------pSAMGRNNlVTPVVYTNINGKQC----GDKIELLILKAKKNLEHCTEE 216
gi 1019065608 318 rLDPERNKkvltagcicdcecdQFqsesvsfsRQSTQPFS-------------------DDKIELLILKAQRTLEHSSEV 378
gi 1033366811   1 ------------------------------------------------------mpllkdDDVDILLHKAWKTLESSAEE 26
gi 821464444  321 LVNCQQNCel-----------gQFqy-----eNIPFS--------------GQSKkpfsDDKIELLILKAKRSLEHSPEG 370
gi 34533005   207 ELVNEYKC--------------DFeh------sQCQCENPlLP--------GQSTkpfsGDKIELLILKAKRNLEQCTEE 258
                          90
                  ....*....|....*.
gi 73620603   215 LAKPVE-KDD-----S 224
gi 73620602   219 FPKESSfTED-----S 229
gi 625221283  220 IPKESSfKDS-----S 230
gi 780172120  735 LNMSSHlEQNahtpeS 750
gi 397513973  218 LPKSMK-KDD-----S 227
gi 431896179  217 LPKSMK-QDD-----S 226
gi 1019065608 379 MSNTAK-NEG-----S 388
gi 1033366811  27 LTSALK-NDG-----S 36
gi 821464444  371 LSSTMK-NDV-----N 380
gi 34533005   259 LPKSMK-KDD-----S 268
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