Conserved Protein Domain Family
PRAS

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pfam15798: PRAS 
Proline-rich AKT1 substrate 1
This domain family is found in eukaryotes, and is typically between 117 and 132 amino acids in length. PRAS domain family is found in eukaryotes, and is typically between 117 and 132 amino acids in length. It is a proline-rich family that can be phosphorylated by AKT, and in the phosphorylated state binds to 14-3-3. The AKT signalling pathway contributes to regulation of apoptosis after a variety of cell death stimuli, and PRAS is found to be a substrate. PRAS plays an important role in regulating cell survival downstream of the PI3-K/Akt pathway after re-perfusion injury after transient focal cerebral ischemia. Copper/zinc-SOD (SOD1), a cytosolic isoenzyme of superoxide dismutase, SOD, is highly protective against ischemia and re-perfusion injury after transient focal cerebral ischemia, and SOD1 thus contributes to the inhibition of direct oxidation of PRAS and the activation of its signalling pathway. PRAS is also a mTOR binding partner, and PRAS phosphorylation by AKT and its association with 14-3-3, a cytosolic anchor protein, are crucial for insulin to stimulate mTOR (mammalian target of rapamycin).
Statistics
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PSSM-Id: 318092
View PSSM: pfam15798
Aligned: 8 rows
Threshold Bit Score: 161.559
Threshold Setting Gi: 762082474
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82180259  160 LFVMDEDSNSQDcEPFFESDQEESTDD-GSLTDDVP--G--HPPPQRn---------YQQYAKSLPVTVPVWGFKEKRQQ 225
gi 762082474 248 MFLLEDSSPSHD-EPFYSSEEEEEEEDtSRRSSTTPmkS--GRFQKK----------PLQYSSSVPIMVPRWGVSGNKDS 314
gi 410903167 236 VFSMDEDSLSRDcEPFW-SDGEEESTDg-SLSEDAP--PppRGIATGqpaylsrqvnAMALARSLPVSVPAWGFRGTR-- 309
gi 327291312 157 LFVMDEDSPTQDyEPFFDSDL-ESTDD-GSLSEEAP--GqvAPPTLS-----------HQYAKSLPVSVPIWGFKEQRqe 221
gi 686759874 125 LFVMDEDATLQDlPPFCESDP-ESTDD-GSLSEETP--A--GPPTCSvppa--salpTQQYAKSLPVSVPVWGFKEKRte 196
gi 432867492 220 VFSMDEDSVSRDcEPFFESDGEEESTD-GSMSEDAP--PpsRSMAVGqpaflprnahPTALARSLPVSVPVWGCKSNR-- 294
gi 556961423 160 MFAMDEDSPSQDcEPFFESDAEESTDD-GSLSEDIP--ArtRPFPQRt---------YQQYAKSLPVSVPIWSFKEHKps 227
gi 292611804 226 VFSMDEDSLSRDcEPFFESDGEEESTD-GSLSEEAP--PppRGMAMGhlas--rssnPMSMARSLPVSVPVWGYRNNH-- 298
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 82180259  226 TKVSDde-tSKFPSPDLDRIAASMRALTI----DHSQPFGDLPRPRLNTGDFQ 273
gi 762082474 315 GDESD----EDPTPSDPNEMAASMQALARsitnDERMIFGDRPRPRLNTGDFH 363
gi 410903167 310 SAQGDsgsgERVGCADLDHIAASMKALLVpgatDGTEMFGALPRPRLNTGDFS 362
gi 327291312 222 LRSSDee-tSKHSSPDLEKIAASMRALVLrv-sDGTEMFGDLPRPRLNTSDFQ 272
gi 686759874 197 ARSSDee-nGPPSSPDLDRIAASMRALVLre-aEDTQVFGDLPRPRLNTSDFQ 247
gi 432867492 295 AAQGDgnsgERVGCADLEHIAASMKALLVpgatDGTEMFGALPRPRLNTGDFS 347
gi 556961423 228 KHLDEgdheERLPSPDLEKIAASMKALVMnv-sDGTEMFGDLPRPRLNTGDFQ 279
gi 292611804 299 APQGDshsgERVGCADLDHIAASMKALLVpgatDGTEMFGALPRPRLNTGDFS 351
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