Conserved Protein Domain Family
PUMA

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pfam15826: PUMA 
Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
PUMA (p53 upregulated modulator of apoptosis) is a family of eukaryotic proteins that are a target for activation by p53. The proteins contain BH3 domains and are induced in cells after p53 activation. They bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of apoptosis.
Statistics
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PSSM-Id: 318118
View PSSM: pfam15826
Aligned: 2 rows
Threshold Bit Score: 218.198
Threshold Setting Gi: 395854225
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126329412   2 ARAQQDGSSPEPVEGLPRESPRTFPLGRLMPSAVSCSLCEAGLNP--SGDSMCPApgPALAPSSLLPLAYFCTRQPRAYG 79
gi 395854225  27 ARARQEGSSPEPVEGLARDGPRPFPLGRLVPSAVSCGLCEPGLPAapAAPALLPA--AYLCAPTAPPAVTATLGGPRWPG 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126329412  80 GPRWARAARSpAAGNQgqsgslPSLGPrsaqeeggqeGEPQGASPM-------SGGP----PGVLGPEhgdqgEQQDREI 148
gi 395854225 105 GPRSRPRGPR-LDGPQ------PSLLP----------AEQHLESPVpstpgalAGGPtqaaPEVRGEE-----EQWAREI 162
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 126329412 149 GAQLRRMADDLNALYEQRrREEEQRRHL-SPWRLLYNLISGLLAPQRRNRMPDVEPN 204
gi 395854225 163 GAQLRRMADDLNAQYERR-RQEEQQRHRpSPWRVLYNLIMGLLPLPRGHRAPEMEPN 218
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