Conserved Protein Domain Family
SSTK-IP

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pfam15836: SSTK-IP 
SSTK-interacting protein, TSSK6-activating co-chaperone protein
SSTK-IP, SSTK-interacting protein or TSSK6-activating co-chaperone, is a family of proteins found in eukaryotes. SSTK-IP directly binds to HSP70, is found associated with HSP70 and HSP90 in cells, and facilitates HSP90-dependent enzymatic activation of SSTK. SSTK is a small serine/threonine kinase expressed post-meiotically and essential for male fertility along with two other serine threonine kinases. SSTK is one of the smallest protein kinases, consisting only of N- and C-lobes of a kinase catalytic domain, and forms stable associations with heat shock protein (HSP) 70 and 90. SSTK-IP, its interacting protein, thus represents the first germ cell-specific co-chaperone and protein kinase that requires the HSP90 machinery for catalytic activation.
Statistics
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PSSM-Id: 318128
View PSSM: pfam15836
Aligned: 7 rows
Threshold Bit Score: 178.611
Threshold Setting Gi: 859943469
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905892    1 MEQHTSNPtKEk--AKEEDSVACFCPAKSSPSYIDLPANFTPANFLTIQ-TKLSSGAGQKPKGCLGVLECMYANLQLQTQ 77
gi 859943469   1 MEQRAGRPsGE---AKEESNAVPLCRAKPSPSFINLPASSPPATSLNIQkTKPPSGVDHKPTECLGLLECMYTNLQLQTQ 77
gi 296489713   1 MEQLPSHPtNRr--AKEEGNAVPLCRAKPSPSFINLQASSPPVTLLKILpTKLPSGINHKPKECLGLLECMYANLQLQTQ 78
gi 157818941   1 MEQHTSNPtKEe--AKEEDNVVCLCRAKPSPSYINLQANSPPATFSNTEtTMLPSGAGEKPKECLGLLECMSANLQLQTQ 78
gi 987414485   1 MEKRASHP-NRk--AKEESNAVPLCRAKPSPSFINLQASSPLATFLNVRtAKLPSGVDPKPKECLGLLECMYANLHLQTQ 77
gi 625199563  38 MEQHT-NP-NDk--AKEEDNAVCLCPAKPSPSYINLQANSPSATLLNIQtTKIPSGAGQKPKECLGLLECMYANLQLQTQ 113
gi 355558564  19 MEQHTSHP-NRkvpAKEEANAVPLCRAKPSPSYINLQASSPPATFLNIQtTKLPS-VDHKPKECLGLLECMYANLQLQTQ 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 81905892   78 LAQRQIAILENLQASLSQPGSGRESKNCSLPGLCCKLLLNHLPQfHK 124
gi 859943469  78 LAQQQMAILENLQASMTQLAPGRTSKNSTLPALPRSLLFSHLPQsTK 124
gi 296489713  79 LAQQQMAILENLQASMTQLAPGKENKNSSLPALSRNLLLSHLPQfSK 125
gi 157818941  79 LAQRQMAILENLQTSLSQLGSGRESKTCSLPGLCCNLLLNHLPQfHK 125
gi 987414485  78 LAQQQMAILENLQASMTHLAPGRGRKNSALPALPRNLLQNRLPP-SS 123
gi 625199563 114 LAQQQMAILENLQASLSQLEPGKESNNGSLPALCCNMFLNHLPQfHK 160
gi 355558564  97 LAQQQMAILEHLQASVTQLAPGRGSNNSSLPALSPNPLLNHLPQfSK 143
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