4IRT


Conserved Protein Domain Family
BNR_4

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pfam15892: BNR_4 
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BNR repeat-containing family member
BNR_4 is a family which carries the unique sequence motif SxDxGxTW which is so characteristic of the repeats of the BNR family, pfam02012. It is unclear whether or not this unit is repeated throughout the sequences of this family, but if it is then the family is likely to be bacterial neuraminidase.
Statistics
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PSSM-Id: 318170
View PSSM: pfam15892
Aligned: 53 rows
Threshold Bit Score: 171.668
Threshold Setting Gi: 511270789
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4IRT_A        35 QYISYYDNDGYLVLGKRK-Ld-SEQWTLHRTQ-YQGNVK----------DAHNIISXXIDGEGYIHVSFDHH---G-H-- 95
gi 81443272   72 TYVGYIDIHGNIKAMQYD-Fk-KKR------------QDevlirsyfqpDDHNNPTFLVLPDERIMIFYSRHt--D-E-- 132
gi 524127709  65 sYVGYIDVHGAVKAVQYDfLk-GRRSEVLIRS-YFQP------------DDHNNPTFLVLPDERVMIFYSRH---T-De- 125
gi 506215279  49 TYIGYIDVAGSIQAVQYD-Hv-TQERKQVRVR--AGFQQ----------DDHNNPTFLVLPDGRVMIFYAEH---S-Tt- 109
gi 524137289  50 sYIGYIDVHGNVKATQID-WknNKRTEVLVRS-YFQP------------DDHNNPTFIVLPDKRVMIFYTRH---T-Dea 111
gi 504668552  65 TYAAWVDSYGDVIVGYYD-Hd-AKKIASKVLE-DNFEI-----------DDHDNPSLLFMPDGRLMVFFTKH---S-Sky 126
gi 740771300  61 ivTGWVKKDGSIEMASLN-Pe-TGDAKFNNI--YPQFEF----------DDHDNPAFTQLPDGTIFTMYAWH---AtD-- 121
gi 490538470  63 lYTSYVKIDGYTGMSTLD-Le-SGSRIGDDIDlSSFQQA----------DDHNNGAILPLQNGKMMSLYTLH---DaR-- 125
gi 524204176  56 mfggFVDKEGSIWAFCYD-Ps-TCQ------------SKqyklfnkldyDDHANPSIMALSDQRLVLFFSAHggtK-N-- 118
gi 495893908  65 SYVGYIDVHGAVKAVQYD-Fl-KGR------------RSevlirsyfqpDDHNNPTFLVLPDERVMIFYSRHt--D-E-- 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4IRT_A        96 PLNYCRSIA---PGSLE-LGDKXPXT--GVDE------GNVTY--P--EFyPLSGGDLLFVYRSGSSGRGNLVXNRYSLK 159
gi 81443272  133 PCFYYRISRl--PGDITtLGEEKVIKt----------kDNTTYpsP--FIlSDDPEHIYLCWRGIGWHPTIAKLSLPDQN 198
gi 524127709 126 PCFYYRISQv--PGDITtLGEEKKILt----------kDNTTY--PspFIlSDDPEHIYLCWRGIRWHPTIARLSLPDEN 191
gi 506215279 110 PYFYYRVTAr--PDDLEtLGPEKIIAttG--Y------GNTTY--PspFVmTDQPGYFYLLWRGMNWHPTVARYTLPDPD 177
gi 524137289 112 KIWYRISQK---PGDITmLGEEKYLTt----------kNNTTY--PspFIlSDDPDHIYLCWRGINWHPTIARLTMPDEN 176
gi 504668552 127 PILLFTMKN---PEDISaWEKKELNLndEETYkg--fhSSYTYanP--VMlSAENDRIYLFWRGIDYKPNYSY------S 193
gi 740771300 122 KGVLSNTTTn--GTDISsFGENEIFKpkTEELlknfprETYTYanP--FVlSEEDNKLFVFGRWIGFKPNLII------S 191
gi 490538470 126 RTQYYRVSNtslPLTLEdWGDEKTYPipG----------SATYnnA--YQlSAENGKIYNFFR---VGARDPYYVTFDAN 190
gi 524204176 119 SPIYYAVSKy--PSDISsWEEVQEINpeMEGS------LGVCYtnP--VMlSDENNRVYLFFRGRDFKPTCIYt------ 182
gi 495893908 126 PCFYYRISQv--PGDITtLGEEKKILt----------kDNTTYpsP--FIlSDDPEHIYLCWRGIRWHPTIARLSLPDEN 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4IRT_A       160 ehKWTRVQDi-LIDGe-----NK--RNAYWQLY-VdEKgTIHLSWVWRETWHVETNHDICYARSFDNGVT---WYKTSGE 227
gi 81443272  199 dqVAVEWGPyqIVQS------TG--ARPYAKYMsNgKD-KIYFAYTTGH-PDNENPNFLYFNYIDIHSLQl---KDVKGN 265
gi 524127709 192 deVQIDWGPyqMVQSt-----GA--R-PYAKYYsNgKD-RIMFTYTTGH-PDNENPNWLYLNRVNIKTLQ---LEDVQGK 258
gi 506215279 178 gdVTCDMEPkqIVDSrcseqeTG--KRPYAKYEtNgKD-KIMMSYTYTH-PDNMIPNSLYYSYLDVNTLT---LHGADGH 250
gi 524137289 177 dnCSFDFGPkqIVQSt-----GA--R-PYAKYYsNgKD-KIYLTYTTGH-PDNEMPNWLYFNVIDINNGNgpiLKDIKGT 246
gi 504668552 194 ddMGKTWRKsrILILper-iyNL--RRPYLKVAsNgKD-KIAFAFTDGH-PRNESENSVYYMYYKNGAF-----YDAENN 263
gi 740771300 192 edQGKTWSRq-YVVMsdvpftPN--NRPYVKYYsDgKS-RIHMIFTDGH-PRVESTNSVYYCYYEKGAF-----WKSDGT 261
gi 490538470 191 gdNPTEAKH--FIQNg-----NQwwDRAYAKYAsNgVD-RIDFFFTDGHP--TQKRTSLYHLYIKNGK-----TYKTDGT 255
gi 524204176 183 -dDLKTWSQpiNLVRndpgygQG--GRPYTKITtNhKD-KIFFAFTDAH-PRDRATNSIYFMMYKNGKi-----CKADGT 252
gi 495893908 192 deVQIDWGPyqMVQS------TG--ARPYAKYYsNgKD-RIMFTYTTGH-PDNENPNWLYLNSVNIRTLQl---EDVQGQ 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4IRT_A       228 ---R---Y----EL---PIKLSNAEY-ACR-LP-----Q-----NCELIN-QTSXSADAGGNPYIATYWREPNSDVPQYR 281
gi 81443272  266 ---T---LstiadG---TFKVNKTDDyARQ-YP-----Stl-idNPSARDwVWQVASDENDNPVIAMVRISSDKNSHDYY 329
gi 524127709 259 ---VlstIa---DG---PFKVNRTEQyAVD-YP-----VavvdhTPGVRDwVWQVATDKQGHPVIAMVKISGDKKKHDYY 323
gi 506215279 251 ---Q---La---DLnrgPLKLDNKETdPAHlVD-----C-----QPGIRNwNWDIAVDKEGYPVILFVRINGDKDRHHYC 311
gi 524137289 247 tlkK---Va---DG---PFNVNKTDSyAKS-YPytvvdK-----TANCRNwVWQIATDKDENPVIALTHIDNAKTTHVYH 311
gi 504668552 264 ---E---IgkldGE---PVKPQNASVvYDA--------K-----LTKQKAwVWDVALDREENPVIVYSKFPDD-TNHIYC 320
gi 740771300 262 ---K---IcdlsGL---PFQVSDATVvYKA-DE-----E-----N-GRAW-ICDV-VEQEGTPYILYTRHPQ-ETDHRYH 317
gi 490538470 256 ---L---Ig---NLvdaPFVVSDGTVvYQQ-GE-----D-----GTNRSPwNHEVRYDASGNPVLLYSHQQ-DKNTIDYY 314
gi 524204176 253 ---V---Vs---Etl-gsIIPSQVDKvYDA-T------------RTFDKAwIWDIAFDESEKPILVYARFSDRDNKHSYW 309
gi 495893908 259 ---V---LstiadG---PFKVNRTEQyAVD-YP-----VavvdhTPGVRDwVWQVATDKQGHPVIAMVKISGDKKKHDYY 323
                        330
                 ....*....|....*
4IRT_A       282 IVwND--G--KXWHQ 292
gi 81443272  330 YAkWN--G--HEWKK 340
gi 524127709 324 YTyWD--G--QAWKE 334
gi 506215279 312 YAkWS--G--SHWRI 322
gi 524137289 312 YArWT--G--SAWRD 322
gi 504668552 321 YArWN--K--KSWNN 331
gi 740771300 318 YVwYNaeA--KTWED 330
gi 490538470 315 MAvWD--DtaNQWNK 327
gi 524204176 310 YArWN--G--IKWEN 320
gi 495893908 324 YTyWD--G--QAWKE 334
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