Conserved Protein Domain Family
RNF220

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pfam15926: RNF220 
E3 ubiquitin-protein ligase RNF220
This family represents the central region of the E3 ubiquitin-protein ligase RNF220.
Statistics
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PSSM-Id: 318197
View PSSM: pfam15926
Aligned: 9 rows
Threshold Bit Score: 295.196
Threshold Setting Gi: 242013252
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122105887  25 PRSDPLCCPICGVTLRTNEIDQHFALEVERLDKILKPRRNlhcptggypmgtdmasvgpG----------------TSTS 88
gi 170053947  19 QTSDPLCCPICGVTLRSSEIDQHFALEVDRLDKILKPKQN-------------------L----------------TGQC 63
gi 347970526  18 GRTSPMCCPICGVTLRLHEIDHHFAVEVDRLERILKPKKQ-------------------LpygaggaedgptagpsYSNG 78
gi 568250997  47 TRLDPMCCPICGITLRPQEIDQHFAVEVDRLERILKPKRH-------------------L----------------GGGS 91
gi 762120290 218 lDGQSPCCPICGLTLRNGEVDAHFALEMDRLERIVRSGR-------------------------------------RSRD 260
gi 242013252 216 FSLDPTSCPICGIMVLLGEAEAHFFKELEKLTHLTTINRD-------------------K----------------KYAI 260
gi 307210404   7 FPSDPSCCPVCGVTVRPQELEQHFAQELDRLYKV------------------------------------------SSAT 44
gi 998708744  15 fDSQAPICPICQVLLRPGELQEHMEQELEKLTQLNISKSSi-----------------------------------LKDA 59
gi 973133560 222 YDSQAPICPICQVLLRPGELQDHMEQEMDRLTQLHISKNPa-----------------------------------HKDC 266
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122105887  89 RATATS---------------SG--------AGMANGNrslEDNGEPGPGSNPDECWGTYQKIKNNRQARL--KMK---- 139
gi 170053947  64 FGGGPS---------------SSaaavpgtsSGSSNGH---AENGESSTVVNPDECWGTYQKIKNNRQARL--KMK---- 119
gi 347970526  79 EGPSHS---------------GSgq----lpAARSNGHn--sEETVASPAVGPDECWGTYQKIKNNRQARL--KVA---- 131
gi 568250997  92 GDGGSGvagpssstagsgssnGNge----trSHSSNGHd--EQRGS---VVAPDECWGTYQKIKNNRQARL--KLK---- 156
gi 762120290 261 ATPQGR---------------KTlt----spSGHRQRKdspSIEAAS------QSRYDTYMRIKCNRQSRLsaRSR---- 311
gi 242013252 261 EKYRDV---------------QScf----ptFGNSSSSsssDDNGSLTDSGVPRGRWETYQRIKSNRLSRL--RIK---- 315
gi 307210404  45 SRPRPS---------------RStl----ppTHPQDHPhgsMLHAPSAADGTPQGRWETYKRIKANRQVTI--RVK---- 99
gi 998708744  60 MAAGTP---------------KSil----lsASIKREGdspTASPHSSDDIHHSDRYQTFLRVRANRQTRL--N------ 112
gi 973133560 267 VTPGTP---------------KSil----lsVHIKREGespTASPLSSEDIHHSDRYQTFLRVRANRQTRL--NVDdlcw 325
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122105887 140 -----------------------------TR-----KRKTED-NVCPVCNKSVS---EEITTHVEACLRKSE-------- 173
gi 170053947 120 -----------------------------SR-----KRKTED-NICPICNKTVL---EELTVHVDACLRKSEtngsnggt 161
gi 347970526 132 -----------------------------RQlavhpSRKPED-NVCPICNKVTL---DDITLHVEACLRKSE-------- 170
gi 568250997 157 -----------------------------SR-----KRKPED-NVCPICNKVTL---EDITLHVESCLRKSE-------- 190
gi 762120290 312 -----------------------------NR-----KKRPDE-TVCPVCNDRVVgspEELTAHVEVCLKRKS-------- 348
gi 242013252 316 -----------------------------NR-----KKKNGD-PVCPVCNEKIQgsvENINLH----------------- 343
gi 307210404 100 -----------------------------NR-----KRKADE-TSCPVCSERLSgtpEELNQHVDRCLNKQNngnp---- 140
gi 998708744 113 -----------------------------ARigkmkRRKQDEgQVCPLCSRPLSgseEEMSRHVEQCLAKREg------- 156
gi 973133560 326 crryaresgktvplrphngapfvpccprhARigkmkRRKPEDgQRDGACGA----------------------------- 376
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122105887 174 -T--------------NGSgsngrinDSD--------DDDASIDVE-G--ESYEVYEWAGQTRIRTTTMVhqSGAFPSTA 227
gi 170053947 162 tS--------------RGT-------DSD--------DDDASIDVEgG--ENFEVYEWAGQTRVRTTSSLhqSGSFASTT 210
gi 347970526 171 -PqrngtnatangggsEDD-------DDD--------DDDASIDVEg---ESFEVYEWAGQKRVRSTTMLg-PGAHGGLG 230
gi 568250997 191 -G--------------QRN-------GIEdaddddddDDDASIDVEe---VTYETYEWAGQKRIRSTTLLs-PTALAGVA 244
gi 762120290 349 -------------------------------------EEDEPVDVEgD--EQCEEYTWAGQTRIRATTLL--QGGLGGSG 387
gi 242013252 344 -H--------------TDE-------AEE--------DEDENIDVEgDs-EVYGEYEWTGRHLIRATTFL--VGGFTAGL 390
gi 307210404 141 -----------------------agqNAT--------LDEEEVDVEgDa-ETFDEYEWAGQRRVRATSML--VGGFSAAG 186
gi 998708744 157 --------------------------SCM--------TEDDSVDIEnEngNRFEEYEWCGQKRIRATTLL--EGGFRGSG 200
gi 973133560 377 --------------------------------------EEDSAEMEgEngNRFEEYEWCGQKRVRATSLL--EGGFRGSG 416
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 122105887 228 VRVTNAE------------DTDDELN--VDGDETQIYGPPQYSERDVVYPVAEQRCKDS----YLRGLVMA-NEPI 284
gi 170053947 211 VRVTNAD------------DTDDELN--VDGDETQIYGPPQYSERDIIYPIADNRYKDS----YLRGLVMA-NEPA 267
gi 347970526 231 VRLTYAD------------DTDDELN--VDGDESQVYGPPQYSERDVIVTGRGASGSSS----ALRELLIA-NDPP 287
gi 568250997 245 VRVTNAD------------DTDDELN--VDGDESQVYGPPQYSERDVIVSSDGSASG------ALRQLVMA-NEPH 299
gi 762120290 388 FQTYSSKrh---------iEEDIDLD--VDGDDSKQYGEPQFSEADII-PCSSEEPGEDkeraALRGAILGsSASS 451
gi 242013252 391 LTSDTSSssnnhh-hqqplEKNERIPnlIEGEDSNCVTPAQFSDTDTSYNADDDNVKDKggkhREKNSIQTiNESD 465
gi 307210404 187 LATSSSNrsgpgggpgnqeDEDVDLV--VDGDDAAEFGPAQYSEADVVAPRIDGTLREQkerdALREAVISpNAPH 260
gi 998708744 201 FIMCSGKen---------pDSDADLD--VDGDDTLEYGKPQYTEADII-PCTGEEPGEAkereALRGAVLNgGTPS 264
gi 973133560 417 FVTCNSKen---------hDSDADLD--VDGDDTLEYGKAQYTEADII-PCSGEEPGEAkereALRGAVLNgGTPS 480
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