Conserved Protein Domain Family
PrlF_antitoxin

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pfam15937: PrlF_antitoxin 
prlF antitoxin for toxin YhaV_toxin
PrlF_antitoxin is a family of bacterial antitoxins that neutralizes the toxin YhaV. PrlF is labile and forms a homodimer that then binds to the YhaV toxin thereby neutralising its ribonuclease activity. Alone, it can also act as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon, probably regulating its expression negatively. Over-expression of PrlF leads to increased doubling time.
Statistics
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PSSM-Id: 318206
View PSSM: pfam15937
Aligned: 9 rows
Threshold Bit Score: 137.087
Threshold Setting Gi: 81739351
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81739351   19 ATITDRGQTTVPAAIRKMLALGK-RDQVVFRGLADGTVVIAKK-QL-SADhgDPVIGTFLAFLARDMGSEPAR---I--- 89
gi 134687     15 SKVTIRGQTTIPAPVREALKLKPgQDSIHYEILPGGQVFMCRL-GD-EQE--DHTMNAFLRFLDADIQNNPQK---T--- 84
gi 503338774  15 SKVTRRFQTTIPATIRKALNLTE-NDRIQYKILPDGQVVISRQ-LE-EAE--DPVISAFLGFVAKDMLNNPEN---M--- 83
gi 501601385  11 STLTKRYQTTIPESIRKVLGLKK-HDKICYTILEDGQVTISRA-AQ-TEN--DPILENFLVFLAQELKKNPQH---L--- 79
gi 506368563   9 STITAKGQTTVPKSVRQALGVDY-GGRIAFFVDDQHRVYVEKA-TE-EAS--DPVVDRFLEFLAQDMSKHPGA---Svta 80
gi 736464957   9 STITAKGQTTVPKIVRQALGVDYgG-RIAFFVDDQHRVYVERA-TE-EAS--DPVVDLFLEFLAQDMSKHPGTsvtA--- 80
gi 299063269  14 SRLTERSQTTIPAAIRDALQLKPgE-FIEYALLPGGKVVMSRR-EE-EAE--DPVVPQFLAFLENDMMTNPHH---I--- 82
gi 497255361   9 STLTDRYQTTVPETVRRALRLGK-RDKIHYTIRPGGEVVLTRA-EDsEED--DPVLGQFLGFLARDIATHPER---L--- 78
gi 500263604   9 STLTDRYQTTVPETVRRALKLGk-RDKIHYTIRPSGEVVLTRVeAS-GSD--DPVLGQFLSFLAADITRHPER---L--- 78
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 81739351   90 R--PVPkslV---A-RG-KGLVKGVKVDLDAALPED 118
gi 134687     85 R--PFN---I---Q-QG-KKLVAGMDVNIDDEIGDD 110
gi 503338774  84 Q--PVT---LslhE-KI-NVLTAGMAIDLESPLSDD 112
gi 501601385  80 Q--GISanlV---S-HL-KSLVADVDLDLDAPLSDE 108
gi 506368563  81 L--PAS---L---RdRV-AALVGNMDVDLDAEIDGD 107
gi 736464957  81 L--PAS---L---R-DRvAALVGDMDVDLDAEIDGD 107
gi 299063269  83 HavPVE---F---W-AGiQQLTAGVEVDLDGPLTDD 111
gi 497255361  79 Q--AIDvsfV---Q-RL-QSLTGGIEVDLDAPLSAD 107
gi 500263604  79 K--SVDtglV---Q-RL-QSLVGDVDVDLDTVLSAD 107
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