Conserved Protein Domain Family
Unpaired

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pfam15972: Unpaired 
Unpaired protein
Unpaired protein activates the JAK pathway.
Statistics
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PSSM-Id: 318234
View PSSM: pfam15972
Aligned: 10 rows
Threshold Bit Score: 279.385
Threshold Setting Gi: 195567487
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121993282 187 RKRH-RKRNSNWIDYRNFNESTTALEWVNPCGGSYH-PSAG----DRFSR---LRPRQSFNQLKRHAFREYRGLN----- 252
gi 195172091  41 QKRH-NLGNFRQRFQRELNGSITRVDWENTCGGNWTgPEDWv---RPAKRc--KKRQLVIHALQNHTRSELRSLRae--- 111
gi 125980652 187 RKRH-RKRNSNWIDYRNFNESTTALEWVNPCGGSYHpSAGDr---FSR-----LRPRQSFNQLKRHAFREYRGLN----- 252
gi 195392888  40 QKRHyTSVSFKERFHRELNSS--VLDWSNGCGGNWTgSDEErnpvRAHKRc--AKHKKLLRTLQNKTGRELRQLRtdnkl 115
gi 195058851 120 QKRHyNGGSIKARFYSELKR--TELYWSNACGGNWTgPASDtsvlRPHNRc--AQHKKLLRQLQKKARSELNELRtnnkq 195
gi 964088271 218 HKRHhPNCSFRCRFQTELNASLEVLDWENTCGGNWTgRDIK----YKHRPntnKKRRMILKGLHDQTNKELIILQdddkn 293
gi 195567487  71 RKRH-RKRNSNWIDYRNFDENTTALEWANPCGGNYH-PSAG----DRFNR---QRPRQSFNQLKRHAFREYRSLN----- 136
gi 161077917 100 QKRS-RAANFRLTFQQKLNASSTHLDWENTCNLKPTgLNETh---SKAKRc--KKRQRILQNLQNQTGRELRGIQaedka 173
gi 195058843  63 RKRH-RKRNSNWYDYRNYSENNTAVEWMNPCGGSYYtPSAS----ESRRA---QRPKQIFNQLKRAAGTEYRELN----- 129
gi 968038803 125 RKRH-RKRNSSWYDYRNYNENTTAPEWINPCGGSYHtPSAT----ESRRA---QRPKQIFNQLKRAAGTEYHELN----- 191
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121993282 253 ----------SSQD-SVIDIRNMTMWSLHTQNYKFLPKLKSNS-TIALKRWYRNMQTYVASFAYLRRLQIRWDQRFITRE 320
gi 195172091 112 --------nkDTATtKAIDISQQRKWALHSGTYKFLPRLNASShQLNLRHVHRDLQFYVGAFSYLRHAQLHWDYSNTQTE 183
gi 125980652 253 ----------SSQD-SVIDIRNMTMWSLHTQNYKFLPKLKSNS-TIALKRWYRNMQTYVASFAYLRRLQIRWDQRFITRE 320
gi 195392888 116 rqtvhsmkaqDTGSnQAIDISEHGIWKMHSSQYNFLPRLNASGqQLALRRAHHDLQFYVAAFSYLRHAQLHWDYENLQKQ 195
gi 195058851 196 rqqvnslkaqVTSSnQAIDISKYRMWSVHSSKYEFLPRLNTTEhQLALRRVHNDLQFYVAAFSYLRHAQLHWDYENIQKQ 275
gi 964088271 294 rrttnserelAKKYnKAIDLKQRERMALHKNQYNFLPKLNATSsQLKLRHVHRDLQLYVGAFSYLRHAKLHWDYANLQAE 373
gi 195567487 137 ----------SSQD-SAIDIRNMTMWSLHTHNYKFLPKLKPNS-TIALKRWYRNMQTYVASFAYLRRQQIRWDQRSITRE 204
gi 161077917 174 ri-ttnadklATVStKTLDIVEKNKWRFYKGNYRFLPRLNLTSkQLNLRHAHRDLQIYVGAFTYMRNIKLHWDLANLQAK 252
gi 195058843 130 ----------STQDhKGIDIGDMQVWSLHKYNYKFLPKLKPNS-TIALKRWYRNMQTYVASFAYLRRVQINWDRQNLKRE 198
gi 968038803 192 ----------STEDhSGIDIRDMHMWSLHKYNYKFLPKLKPNS-TIALKRWYRNMQTYVASFAYLRRVQINWDRQYLKRE 260
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121993282 321 STTARELRELLLSSRRILCELETAVNQT-SPrrkhrrsspngsisigvqlpqisrtem------nkrlklrskgaggpgp 393
gi 195172091 184 SVMSAELGRLRKSARRVLCSVEVAINAT-NRlyaskgqknsrravpllhskilsr-----------elmekrlqqfktpl 251
gi 125980652 321 STTARELRELLLSSRRILCELETAVNQT-SPrrkhrrsspngsisigvqlpqis-------------rtemnkrlklrsk 386
gi 195392888 196 SVLSAELLRYRSSARTVLCIVEEAINGS-SRlyapspqkhqrhkklslhqiktvpr----------epmekrlqkfktpl 264
gi 195058851 276 SVLSSELQRLRASARSVLCLVEEAINGT-SRlyapirknqrqkmaaperiktvpl-----------hlmekrlhqfqtpl 343
gi 964088271 374 SVMSADLERLRASARRALCNVEMAINAT-NRlypahvpaghklrrpmtrqlm-----------------erklqkfktpl 435
gi 195567487 205 SSTARELRELLLSSRRILCELETAVNQTqSPrqkqrrsgaavtavggttmlgqqlpqis---rlemnkrlklrsktsapg 281
gi 161077917 253 SVLSDELGRMRKSAREVLCSVEEAINLT-NLlytpnrqrapqprgqkkrrqaqpvvtykilprklmekrlqqfnstlvpl 331
gi 195058843 199 SAIAKELKRLLLSSRSMLCELETAVNRTypmpltlgvsakqrrqlqlpqisrndmnrr---lklrskmrpaaaaaaaaat 275
gi 968038803 261 SNVAKELKKLLLSSRSMLCELETAVNRT-YH------------------------------------------------- 290
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121993282 394 isgaitgsmkTANEAD----------SIDMRFVKHHYYEFLRTMWQLLRRDGKREKKRPHRP 445
gi 195172091 252 vqlhheaalaARSLPAkqptq-svqlAVDARFVKFEYVQYLNNAWKILARQRKQLCRNQRQR 312
gi 125980652 387 gaggpgpisgAITGSMktan---eadSIDMRFVKHHYYEFLRTMWQLLRRDGKREKKRPHRP 445
gi 195392888 265 velhrqavlaARNQPAaeps---kphHLDALFLKFQYMEYLKHMTQLLAKQRKRDCTSSPQQ 323
gi 195058851 344 valhrlavlvANNESAaqpt---kpfELDALFLKYHYMKYLKHITQLLAKQRKRNCTSRPga 402
gi 964088271 436 vqlhrqatlaAGGAEMmppnlhydqlAKDALFVKFKFVRYLKSIRKILKTQTKPKNRTSHIS 497
gi 195567487 282 mggaassasmAAGEAD----------SIDMRFVKHHYYDFLRTMYQLLRRDGKRVRSRPRKH 333
gi 161077917 332 velhqqatlaARGEDVppppddlmvlEQHALFTKLKFVQYLKSIRKILANQRKSLCKATTHV 393
gi 195058843 276 tteaasvaatAIGEAD----------PMDMRFVKHHYYEFLRTMWQLLRRDSKRERQQRRQK 327
gi 968038803 291 ----------AAGSGPhvkfqvssiss----------------------------------- 307
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