Conserved Protein Domain Family
G_path_suppress

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pfam15991: G_path_suppress 
G-protein pathway suppressor
This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Statistics
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PSSM-Id: 318248
View PSSM: pfam15991
Aligned: 14 rows
Threshold Bit Score: 135.775
Threshold Setting Gi: 675861222
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82240289    5 LERPKLSNAMARALHKHIMRERERKRQEEEEvdK-MMEQKLKEEEERKRKkemE---ERMSLEETKEQIMKMGVKLQGLQ 80
gi 121957507  19 VVKTEKEEQLWNALKRHIMRERERKKQELEA--E-VEEERLRKEREAREK---Q---DVMTLGETKEQIQMLEKQLQELR 89
gi 405957647   6 IDRPKMTKTMYQALKRHIMKERERKKQEQEQ--DaMMMERIKKEEEMRKK---KeqeDSLTLEQTKEQIAQLDKKMEDLK 80
gi 675861222  44 IVRPKMTKSTYEALKKYILKDREKKKQEQEQ--D-KEQERLKKEREMKKK---KeeeDNLTLEQTKEQILQLEAKLASLK 117
gi 556983913   5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdK-MMEQKMKEEQERRRKkemE---ERMSLEETKEQIHKLDGKLSALQ 80
gi 126309170   5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdK-MMEQKMKEEQERRKKkemE---ERMSLEETKEQILKLQEKLLALQ 80
gi 395533552   5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdK-MMEQKMKEEQERRKKkemE---ERMSLEETKEQILKLQEKLLALQ 80
gi 533172251   5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdK-MMEQKMKEEQERRKKkemE---ERMSLEETKEQILKLQEKLLALQ 80
gi 158292900  18 AAKTEKEEQLWNALKRHIMRERERKKQELQA--E-VEEERLRREREEREK---Q---DVMTLGETKEQILMLEKNLDELR 88
gi 568256923  18 AAKTEKEEQLWNALKRHIMRERERKKQELQA--E-VEEERLRREREEREK---Q---DVMTLGETKEQILILEKNLEELR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82240289   81 EEKHQLFLQLKKVLH-EEEKRRR---KE-QsDMTTLTSA----TYQ----------ANmpihpsqhiLSMQaGQVSHg-- 139
gi 121957507  90 NEKQQLFLQLKKVLN-EDDNRKRq-lKE-SvEMFAVHNIpqqqTYL----------PQ---------RTTTaMPPHQqhl 147
gi 405957647  81 AEKHDLFSQLKKVLHqEDETRKKaqlKE-QsELQIMQHSt--vLGL----------PH----------AMTgRPILYr-- 135
gi 675861222 118 QEKHELFSQLKKVLHqENDLRQRnqlKEqQnEQANLQQQm--lTGLgvnaqffmqqQQqqqr--qkyLSISsq------- 186
gi 556983913  81 EEKHQLFLQLKKVLH-EEEKRRR---KE-QsDMTTLNA-----GYQ----------PGmtvhssqhlINMQgSPVGHs-- 138
gi 126309170  81 EEKHQLFLQLKKVLH-EEEKRRR---KE-QsDLTTLTSA----TYQ----------QGlavhtgthlLSMQgSPGGHs-- 139
gi 395533552  81 EEKHQLFLQLKKVLH-EEEKRRR---KE-QsDLTTLTSA----AYQ----------QGlavhtgthlLSMQgSPGGHs-- 139
gi 533172251  81 EEKHQLFLQLKKVLH-EEEKRRR---KE-QsDLTTLTSA----AYQ----------QSltvhtgthlLSMQgSPGGHn-- 139
gi 158292900  89 NEKQQLFLQLKKVLN-EDDNRKRq-mKE---EMFAIQNIpq-qIFL----------PQ---------RSMP--PHQQqhm 141
gi 568256923  89 NEKQQLFLQLKKVLN-EDDNRKRq-mKE---EMMAIQNIpq-qIFL----------PQ---------RSIC--PPHQqhl 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82240289  140 ------------------------rPAVLLGe-RSKQLFQSPVIPArHFQSQPGfsaGGSEhgqYSGAQPGHSpYGVTQt 194
gi 121957507 148 ----------------------ihkTTPPVNvaKRTHSPSP----Q-GYYKQTTaspAYPPpqpQKLEEGRRGpGEVARa 200
gi 405957647 136 ------------------------pPQPQM------------VQSS-FPQSQAGp--GYPTqssHAFQQAGYV-P----- 170
gi 675861222 187 ------------------------hAPPTQTslKRPRSPSPSTTPS-HYPHFAGsgsSYPNsgsGGGSVGVIG-LGQGY- 239
gi 556983913 139 ------------------------rPGPLLGe-RSKQMFAAPVITGrPYPGQPGftpGTPEhsqYQSSQSGHGaYHVGQs 193
gi 126309170 140 ------------------------rPGTLMSadRAKQMFGPQVLTTrHFVGSTAf-aGTSEhgqFQGSPGGa--YG-AQp 191
gi 395533552 140 ------------------------rPGTLMSadRAKQMFGPQVLTTrHFVGSTAf-aGTSEhgqFQGSPGGa--YGAAQp 192
gi 533172251 140 ------------------------rPGTLMAadRAKQMFGPQVLTTrHYVGSAAafaGTPEhgqFQGSPGGa--YGTAQp 193
gi 158292900 142 mhkvsqpevmlsseriftdaypnlqGNPQVNvgKRTHSPSPVQHVQ-GYYKQPNl-nNQPYalpQKS------------- 206
gi 568256923 142 ----------------------ihkGNPQVNvaKRTHSPSSPQHLQ-GYYKQPNl-nNQIYhspQKMDEGRRS-GEVARa 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82240289  195 qhtspfASSQPVPANYASSSQLrgasAFQ------Tmqy------lpHQQ-QGYAVHSHft-sQPGYi---pSAGIPLQK 257
gi 121957507 201 ------VLWNKS--QYCPPGTL----FYP------Anap------qpPN----QPDTRQpq-pQIIYppyqgGLPMSIRQ 251
gi 405957647 171 ---------SKSPVKYNPGSQS----AFSsysnpyAhqq------tkQLQeSGFPAYRMq---QPGYittqhGSSIPLQK 228
gi 675861222 240 ------TGKGDGPAIKQGSSYT----TVL------Lpqn------hqPPPpNLISQSPS----QQQHsy--iQQQQQQIQ 291
gi 556983913 194 qh--afGGGQPVSMSYTGSQQLrgtpTFP------Tmqy------lsSQQ-SGYAVHGPfa-gQQGF--------IPLQK 249
gi 126309170 192 pp--hyGPTQP---GYSPSQQLrapsAFP------Avqy------lsQPQpQSYAVHGHyqppQTGFlq--pGNALSLQK 252
gi 395533552 193 pp--hyGPTQP---GYSPSQQLrapsAFP------Avqy------lsQPQpQSYAVHGHyqptQTGFlq--pGNALSLQK 253
gi 533172251 194 pp--hyGPTQP---AYSPSQQLrapsAFP------Avqy------lsQPQpQPYAVHGHfqptQTGFlq--pSGALSLQK 254
gi 158292900 207 --------------QYCPPVG-----FYP------GappanpqdnrpPP----QP--------QILYpy-qsSLTIPMRQ 248
gi 568256923 197 ------VLWNKS--QYCPPVG-----FYP------Snpp------snPP----QPDVRQp--qQILYpy-qsNLTIPMRQ 244
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 82240289  258 QLEHAn-----------------qQSGFTDSS-PLRPm-HPQALHVSAASLlsTPPI 295
gi 121957507 252 SYQVDla---------------pqPGP-APPG-PQKApeLIKPGPGPGPAPgnVYHI 291
gi 405957647 229 QLEHAn-----------------qQSGFNEEKyKLQQqnSAIRGVAPLPGQqsMMHq 268
gi 675861222 292 QQQRQq-----------------aPSPYQIPS-NQKYhqSSSSSSPASGYFpsSNHF 330
gi 556983913 250 QLEHAn-----------------qQSGFTDSS-TLRPmqHPQALH-PNPGLlaASQI 287
gi 126309170 253 QLEHAn-----------------qQSGFSDSS-SLRPm-HPQALH-PTPGLlaTPQL 289
gi 395533552 254 QLEHAn-----------------qQsgfsdssslrpmhpqalhptpgllatpqlpvq 293
gi 533172251 255 QMEHAnqqtgfsdsscqlclcslpcapcipklctqhldsspllsclcrcnqqesqal 311
gi 158292900 249 YVDIPs-----------------qPGPMVQPK-PEQLivSGKVGPLP-PSQanLYHI 286
gi 568256923 245 YVDIPptqqhqqqhqqhqqqhlhqSGLLKQSE-PPHMvqSSKAIMGQ-AAQpnIYHI 299
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