Conserved Protein Domain Family
DUF4770

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pfam15994: DUF4770 
Domain of unknown function (DUF4770)
This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 169 and 182 amino acids in length. There is a single completely conserved residue L that may be functionally important.
Statistics
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PSSM-Id: 318251
View PSSM: pfam15994
Aligned: 27 rows
Threshold Bit Score: 180.205
Threshold Setting Gi: 198476661
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75009900   46 LLRLGVQPLIRNRELHRIWRFSRGQKLAFLYFLFQEHYDTGTSC----GK-----------YSVNGQLLLSAIAYLDLPA 110
gi 121995383  39 LYHLGLRPMVKASRIKTIMKISNGSEIAFLYFIWEAEYKPINTS----VDtect----rknFTVNEQLLLSAIAHLDMPA 110
gi 74869690   52 ITQLGIYPPVGAAQIKDIIAMSQGSDLAFLWFLWEFAYKSPPKC----GKdncns--dsehFTVNEQLLLSGIAHLDMPS 125
gi 195440129  52 FSQLGLHPPVPSKRLEAIMKISHCNDLAFLWFIWEAEYKQPRNK----GSsmnsmdvdnefFTVNEQLLFSAMAHLDMAA 127
gi 195443678  30 LVQLGITPLINQMSLKKLINMSRGSDLAFLYFLWEGFYKCNRT------E-----------YTYNEQVLMSSVMHLDLDM 92
gi 195065508  48 LSLLGLQPIANAKQIKTIIDISYINDLAFLWFLWEAYYKKPHSClgeyND-----------FTINEQLILSAIAHLDMTS 116
gi 195397884  53 LNLLGLHPMINANQSRVLMGISQANDLAFLWFLWESHYKTTHIC----QEdr-------ndYTVNEQLIFTAIAHLDMTS 121
gi 198476661  49 LLRLGVCVQFDCCRLNKMIELSQGDNLAFLYFLYTMEYQSDCPH----KK-----------YTLNEQIVLSAIAYLDMPA 113
gi 195339210  46 LLRLGVQPLIRNRELHRIWRFSRGQKLAFLYFLFQEHYDTSSSC----GK-----------YSVNGQLLLSAIAYLDLPA 110
gi 964106425  51 LMRLGLRPLPKPSQLTQLVKISRAQVLALLYFVFQKNYNIDQYC----GK-----------YSVNAQLLLSALAYLDLPA 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75009900  111 TFRALDKVLPLPGVLCGQTKIQMK--------NRQINNNRSARPSIIIPNsktypqnideempldlpatfraldkvlssh 182
gi 121995383 111 TLRELDRLLPPSTHSKKLRPGGCA--------KIRHKLVTQPKPTRRDCE------------------------------ 152
gi 74869690  126 TLRALDALLPPATQSKKLNSQIKT--------EQKSSIPRRRKPKNYDL------------------------------- 166
gi 195440129 128 TLRALDRILPPPAHSKKKFNHEQNnhvylgekEFRNQTYGKSQPYL---------------------------------- 173
gi 195443678  93 TLYELDRILPAGHLSHKSQARLDKkkrlmlrqTETRPPVKRHGVKTNTL------------------------------- 141
gi 195065508 117 TMRGLDKILPISDHSKKYQELRRA---------RVQKLTEQRQPKLKTRTken--------------------------- 160
gi 195397884 122 TLRGLDKILPTAEHSKKyqeq--------qrlRQQQKLARQLRRKMQMNNhiwpn------------------------- 168
gi 198476661 114 TIEALEKILPIPE------KRLKAgpskpnpsEKKCKEN-------IKQGtk---------------------------- 152
gi 195339210 111 TFRGLDKVLPLPG--CGQAKIQLK--------NRQ---NRSARPSIIIPNstaysknieeempldlpatf-raldkvlss 176
gi 964106425 116 TFKALDQILPLHETNTVTETTEKEkyvkqtvlPERRILRPIGGPv----------------------------------- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75009900  183 ttkkkpsssrkSYYFQKQPRPKttprrsnQFLS-----D-SPLLKI-------------QIPNEvgdpkedEDRWYADFQ 243
gi 121995383 153 -----------SPYFAPLRRPK-------LFNPaknqqWgPPDSKLrfpeyd-knrgllEIPEE-------DLRWFSYYK 206
gi 74869690  167 ------------PYFAPLVRPR-------EYIPkck--frPPETKLlfpeyshyidrmkQIPNE-------GSRWFAQYK 218
gi 195440129 174 -----------SPYFAPLVRPKqfv-pmrKLV--------PEFEKLefpeyshykdpmyEIPNE-------KSRWFSQYE 226
gi 195443678 142 ------------PYFWKHPRPKqi---rtTKLS-----K-KNDISVnfpfwrcgekpnyKFNSA--------HPWFASYP 192
gi 195065508 161 --------vnsSPYSVRQVRPKyfapissL--S-----K-PRDRKVvfphydrykdpmyIIPNE-------SSRWFAKYE 217
gi 195397884 169 ------daakdSPYMVPQLRPKpy---lpKLF------K-PKERSVsfsqyeqykdpmyNIPNE-------SSRWFATYE 225
gi 198476661 153 ----------vLPYFEKQRRPKrk---rkYFHS-----T-PHPYEAgipnesk-------------dsedpdyRWFADYE 200
gi 195339210 177 httkkksslrkSFYFQKQPRPKttprrsnQFLS-----E-TPLLKI-------------QIPNEvgnpkddEDRWFTDFQ 237
gi 964106425 161 -----------sPYFQKQPRPKihr-qenRFVT-----R-PPPFTVeiphe---skdikEIDNH----------WFSDYK 209

                 ....*....
gi 75009900  244 FHPIQRTVK 252
gi 121995383 207 LSPAKRVIK 215
gi 74869690  219 LCPAKRVVN 227
gi 195440129 227 LSPGKRIIK 235
gi 195443678 193 LSPMKGEIy 201
gi 195065508 218 MSPAKREVK 226
gi 195397884 226 LSPIKREVK 234
gi 198476661 201 FHPSRRIVK 209
gi 195339210 238 FHPIQRTVK 246
gi 964106425 210 FQPLYRKIQ 218
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