Conserved Protein Domain Family
Phage_holin_5_2

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pfam16079: Phage_holin_5_2 
Phage holin family Hol44, in holin superfamily V
Phage_holin_V_2 is a family of small hydrophobic proteins with three transmembrane domains of the Hol44 family. These proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion. Full activity of the endolysin Lys44 from oenophage fOg44 requires sudden ion-nonspecific dissipation of the proton motive force, undertaken by the fOg44 holin during phage-infection.
Statistics
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PSSM-Id: 318329
View PSSM: pfam16079
Aligned: 65 rows
Threshold Bit Score: 43.2652
Threshold Setting Gi: 523988406
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75542328   45 LVPALYVLGLMLKQTKQIKDWTIPWILLVVGILGS-----------------IALIGlnanAVIQGILTAGVAVFGNQLI 107
gi 524580736  14 LVPILYICGIAIKKSS-IADYKIPFILGGIGIVLAniwlfaadipsgwqdalTKLLS----GTMQGIICAACSVYTKNIV 88
gi 505338626  15 tAIALYFMGIALKEAQAVKDKYIPLILGCAGILICgiyifatcscknaqdiaMAVFT----STTQGVLVAGLSTYVNQLI 90
gi 769182602  16 VAIALYFVGMALKQAQAVKDKYIPLILGGISIAICaiyvfatctcgtgqdiaMAIFT----AITQGILIAGLSTYVNQIV 91
gi 951079164  16 VALVLYFVGMWIKQSEAVKDRYIPLINGGLGIVICgiyvlatstcrsgqeifMAIFT----AITQGILLAGLSTYVNQII 91
gi 524643798  14 VAVVLYFIGMWLKQSETVKDKYIPLINGLIGVAICaiyvfatcacgsgqdiaLAVFT----ALTQGVLVAGLSTYVNQIF 89
gi 524767799  14 VAFVLYFFGVALRQAQAVKNKYIPLILGGISMVLCavwvmatseietakegaMAVFT----AVTQGILVAGLSNYVNQII 89
gi 492752923  15 VAFVLYFIGVGLKKSQAVKDKYIPLILGAIGVVVCaawvfagcpistyrdviMALFT----AFTQGVLVAGLSTYVHQII 90
gi 496538906  16 VAVVLYFIGMGLKQSQTVKDKYIPLILGGIGIVLCavwviascpistgqeiaMAVFT----AIVQGILVAGLSTYVNQAI 91
gi 524438862  15 VAVVLYFIGIGLKKSETVADKYIPAILGVVGVVICgiyvvatcdlkgtqniaMAIFT----AIVQGILVAGLSNYVNQVF 90

                 ...
gi 75542328  108 KQT 110
gi 524580736  89 KQY 91
gi 505338626  91 KQL 93
gi 769182602  92 KQA 94
gi 951079164  92 KQA 94
gi 524643798  90 KQs 92
gi 524767799  90 KQI 92
gi 492752923  91 KQV 93
gi 496538906  92 KQM 94
gi 524438862  91 KQL 93
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