Conserved Protein Domain Family
COR

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pfam16095: COR 
C-terminal of Roc, COR, domain
The C-terminal of Roc domain, COR, along with Roc functions as the putative regulator of kinase activity. It functions as a proper GTP-binding protein with a low GTPase activity somehow stimulating the kinase activity.
Statistics
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PSSM-Id: 318343
View PSSM: pfam16095
Aligned: 47 rows
Threshold Bit Score: 151.963
Threshold Setting Gi: 123580283
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74858871  1918 PRSYMLLENLVKEet----kKR--I--I--PTIPWTEFIQMGTICTITDEAELLRATMFLHQLGSLVYF-----PK-E-- 1979
gi 405951844 2667 PQVWLNLEDKMIKm------RK--E--N--AILDWGEVEKIAREEGIYHEQDLKEAVSFLDNLGTVQYF-----DT-D-- 2726
gi 405968427 2508 PQVWLNLEKQILAe------RT--K--Q--SILDYSVIEDFAMEHGIFDDKDVKQAIKFLDDLGTVQYF-----DN-D-- 2567
gi 281203817  515 PSSYLLLENLVKEe------RRvrT--I--PTMSWAEFVQLGKLCTINDEDELVRATIFLNQIGSLVYF-----PN-E-- 576
gi 405950628 1839 PMAWLELEEIIKKl------KT--KtkM--DTIEYSQLFKRAGVAGIVNEKEFAEAVAFLHDLGSLQHF-----SG-N-- 1900
gi 909620104  201 PRAWLRAADTVRAa------ED--K------HITPEKLNELLATAGVREPSHQTSLIAALHSLGDLLYY-----PD-D-- 258
gi 196008213 1959 PNIWLEYENSIISc------RN--R--S--SVLSWKEITEIACNHGIFQDDEIREAVKLLTDLGSIQHF------D-T-- 2017
gi 281207111 1147 PIPFVLLRNQLIEtckdasrHS--R--I--PATSQAKIRSIAKSINLESRQ-IDDAMKYLLRCGDILYY-----RD-Dgd 1213
gi 330805452  533 PSSFFTLEEALIEv------KK--K--RipPVMMWQEYINLANICNLKDSVQIQRATEFLHNIGSIVYF-----NDlN-- 595
gi 470241594 1370 PIPYILLRNQLVEsanearrLS--K--L--PITSIARVRQISITLGLDAKQ-VDDALAYLCKTGDILMFnqeggDN-D-- 1439
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74858871  1980 PGLKQFVILDPQWITTMLSSIITTKHSY--Ak--dGILNHKSLKQIWRPPqYPTHLHPHLISLLEKFEISYN-LS----- 2049
gi 405951844 2727 -FLRDKVVVDPQWIVNVMACVVSVRASV--IqrndGRFEHSQLDTVW-EK-FAPDLRPWLLSLTEEFDLTYP-LP----- 2795
gi 405968427 2568 -FLRDKVVINPQWIVNVMACVVSVKQSPiqNh--dGRFLHEHIKDVWKS--YDESLHNWLLSLTEEFDLTFP-LP----- 2636
gi 281203817  577 EGLKKIVILDPQWITLMLASIITVKHNY--Tn--qGVILHRDLKHIWKAPfYPQELHPHLLTLLEKFEISFN-FQ----- 646
gi 405950628 1901 EYLHSKVVVNPQWIVDVMACVVSVKESP--Ik--nGRLKHEDAKKVWKD--YPESLHQWLLRLTEEFDLTFC-IP----- 1968
gi 909620104  259 EELCDLVVLRPQWLTTYISRVLDSEEVL--Ne--gGLFHRSLWATLWRD--VERSMRRHLSRMMENFDLSYR-TE----- 326
gi 196008213 2018 EMLREVVVINPQWIVDVMACVVSVHDSP--Ik--nGRFHHSDMQKIWS-K-YNSNLHKWLLGLTEQFDLSFS-LP----- 2085
gi 281207111 1214 NELNDIVFLEPLWLSRVLSTVTNLKHQn-------GYLLMGGINQAWDEK-YPRSIHTSLTHLLEQFEIMHSnTG----- 1280
gi 330805452  596 SSVGKMVILDQQWIINCMSSLITSKVLI--Nnc-nGIVRQSDLELVWKAPtYPEHLHSALLSIMQAFEICRP-LS----- 666
gi 470241594 1440 SVFTQLIFLDAAWLSKLVSSVFTLKHQn-------GMLLMDKIHQAWDHL-FLRQLQPSLLYLLENFEIMHS-SHsseeg 1510
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74858871  2050 ----Pdsts---------fetGTSLIPSLLLNDRPAifpslwg---sfnqlvrQF--------GRIYQFEFVPNGFFSRL 2105
gi 405951844 2796 ----Gq---------------QLNIVPCLLPLEPPEefqwpeld--rlddsvhEN--------KIVYRFVYLPGGLFNRL 2846
gi 405968427 2637 ----Gk---------------PINIVPCLLPLEQPTelqwpav---dmehgirEN--------KMLYKFAYLPAGLFNRA 2686
gi 281203817  647 ----Gktssgqlq-dvvhddnARSLIPALLSNECPSefgklwgsnrggvmaaiQY--------GRQYQFDFIPTGLFSRL 713
gi 405950628 1969 ----Qeeg----------skeRVNLVPCLLPESKPKfewpepd----kkngvtET--------KMVYMFDYLPAGLFNRG 2022
gi 909620104  327 ----Dq---------------TASLVVELLPWNPPPyqdewns---perlaqrEL--------RLKYRLHTVPPGIPTWF 376
gi 196008213 2086 ----Nk---------------STNLVPCLLNDDDEEtddldket--lemdgmkET--------KMVYTFQYLPAGLFNRL 2136
gi 281207111 1281 ----Gdn-------------gDSIIVPMLFSEERPVvmamlwp---efdhirqQH--------ERIYQFQFLPKGFFSRL 1332
gi 330805452  667 ----PsdlvkpdeindkevigDRNLVPNLLSDNNSNiitqwdd---fidpdtiLL--------NRQYHLPFLPEKFFGKL 731
gi 470241594 1511 pgsvEde-------------sYQIIVPLLFGEERPTvmpm----------lwpEFdhsrpvtqERIYQFKFLPKGFFSRL 1567
                         250       260
                  ....*....|....*....|..
gi 74858871  2106 MVRILNFARVEakCYWKNGMIL 2127
gi 405951844 2847 QVRLFNFSDGK--MIWKKGSFL 2866
gi 405968427 2687 QVRLFNFSDGK--IIWKNGSYL 2706
gi 281203817  714 MVRILNFASSEaiCYWRNGIIL 735
gi 405950628 2023 QVRLQEYSDYY--IIWKKGSFL 2042
gi 909620104  377 IAREHRFSTS---VRWRSGALV 395
gi 196008213 2137 QVRLCEFTEDQ--TISKRGSKL 2156
gi 281207111 1333 SVKMLQNFDPL--CIWQGGMVI 1352
gi 330805452  732 IIHLMNFTKVE--SCYKRVVVV 751
gi 470241594 1568 SVRMLQNFDPL--AIWQSGMVI 1587
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