Conserved Protein Domain Family
DUF4825

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pfam16107: DUF4825 
Domain of unknown function (DUF4825)
This domain forms the N-terminal, extracellular domain of some homologs of Staph BlaR1 proteases, where it replaces the penicillin-binding domain of BlaR1. It is also found in many uncharacterized proteins in a broad range of bacteria. Its association with BlaR1 homologs suggests it may be involved in substrate-, possibly antibiotic-binding, but this prediction has not been verified experimentally.
Statistics
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PSSM-Id: 318354
View PSSM: pfam16107
Aligned: 33 rows
Threshold Bit Score: 68.4263
Threshold Setting Gi: 81434414
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122317696 190 LQYKSNYAGDNSNVVHLMYSLPYVNGIKpvGCELQTDSepygLIINCQGYGTKERASL------------P---YFKNAA 254
gi 506237817  50 YKYKTPYVGDNSKVVHLIDSLPYANLRKn--VLLQTQVvpygVTVDYDFSSAHKEPQQme---------tY---FQNNAI 115
gi 506325339 343 MENKTLYVGNHVKVGGLIGALPKPDGLEgkGLALQTKSqpygITVNYDRTDDLQAEEEtaa------nkdV---FYRNAI 413
gi 212559620  42 FSYKSQYVGDVSNVSGLLDQLAFGTYRR--SVSLQTVKepygMTVHYDMENTEMGLKKie---------kL---LYDNAV 107
gi 501052213 331 YKYRTPYVGDNSKVLNIINSLPVPETLHhrKIQLFTDKkpygIQITYETTNDVKESFLrk---------eNqliFDENAA 401
gi 291549691  34 SQYKTDYVGDSSNVINIVSGQEYPEGYSydSIEIQSETepygLTVFLKDESSAV---Kle---------dE---LQVNAD 98
gi 504028816  39 TQYHTEYVGDSTKVIQITSKQSYPPGYSydHIAIESKEepygLTVYLTVEGADDDSk------------kK---LKENAN 103
gi 489611716 325 LKNKTEYVGDNSKVGGIIFLLKFPKNVSydFFELFTDKepygVNINLKTDTETKNLYVgee------nrqQ---FQSNAV 395
gi 506250588  32 YEYKTKYVGDNSKVINILSNLKYPKEASynSVQILSEKepygILVKLNINSGKIPEKN------------E---FLKNSA 96
gi 501765806  58 FENKTPYVGNNSKVLHIIDNLQFGNYRG--EVSLQTEKipygVTVNYDFQNLVKEDYQkakieneerlklA---FKRNAA 132
                         90       100
                 ....*....|....*....|....*...
gi 122317696 255 VIFSLIENVGIVTFNIENndgkIAFTYT 282
gi 506237817 116 ILFALIENIDEVTFITRGigkyPKYHYi 143
gi 506325339 414 MLLSLIDNVDSITFTVRNanlvTvtree 441
gi 212559620 108 ILFVLIENLDRITFDMNVdakhVSYSFe 135
gi 501052213 402 IIFSLVGNADYIDFVLKTegqfdrtiki 429
gi 291549691  99 MTFDLIGNLGTIDYKTADskeiiasyer 126
gi 504028816 104 VTFELIGNLESIKYIDARtaeeiasftr 131
gi 489611716 396 IMFSLIGNVEYISFTLddglepYSIRYT 423
gi 506250588  97 LLFALIENLSFVKYEdis-nnkIIAEFT 123
gi 501765806 133 MMFCLIENLDKITFVCRTvkgtAEYGFT 160
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