Conserved Protein Domain Family
DUF4862

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pfam16154: DUF4862 
Domain of unknown function (DUF4862)
This family consists of uncharacterized proteins around 300 residues in length and is mainly found in various high GC Gram+ bacteria, but also in several pathogenic and non-pathogenic enterobacteria (Salmonella, E. coli). Distant homology analysis suggests this could be a branch of Xylose isomerase-like TIM barrel family, but this prediction is currently not confirmed by experiment
Statistics
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PSSM-Id: 318399
View PSSM: pfam16154
Aligned: 16 rows
Threshold Bit Score: 345.085
Threshold Setting Gi: 501033440
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123064531   4 FVGSYATSP-AweqwDAEAEHAYFTKLKALKNVQGLEHPFTG-----SLHPh-DDDWFIANVSPDWQF-VFTCVPGIMGA 75
gi 81401951    7 VIGAYAALP-A----TRADQETFYDRLHADLEATGLELPFRD-----SIHD--DPAWLASQLAGRFTDsIITAIPGTMMR 74
gi 123586955   4 IVGAYASVP-SdaswDQEAEHLFYQQLKNNTLIDGLEVPFTG-----KLHKy-DNDWFYNQLDKNWCY-VITCIPGTMGE 75
gi 123089916   4 FVGAYATSP-SamgwDAAVESEYYNQLKGYSNIKGLEHPFVG-----KLHGe-DDEWFLQNISSDWEF-VFTCVPGTMAA 75
gi 807232151  13 VVGAYAAVP-S----ARDEQEQFYAGLADRGIASALEIPFRE-----DLFD--PIEWQAEHFTHRFEDsVLTLIPGTMQR 80
gi 504658495   5 IVGAHAAMP-F----EREDQESFYAGLAERNLATALEIPVSD-----SIHE--DPAWFVSQVRGRFRRgVVTALPGTVKR 72
gi 503538411   7 yVSAYITAP-T----EPAAEDAFFDAVGELDLA-GLEFALQP-----EGHRtlDPAWIDAHVPADSDL-VVTLVPAMTVR 74
gi 501033440  23 LVAGYMLAP-T----DPAGEDALFAGLADLDLA-GLEYALPP-----EGTRslEPGWVERNVRPEWDL-LVTLVPTMVPR 90
gi 506364527  10 VVGAYALFAgR----PPEELPAAYRALEGLTTAGALEMPLAEvcgetPGFDv-GPDGLPTLVPAGWGV-VVTCIPAVMGR 83
gi 502629047  30 lLGAYALAP-S----GSPVETEVLAALPALG-VQVLEVPLPA-----PGTAaeTARWVATHLPDDVDL-VVTAIPRTMQR 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123064531  76 LGKNPHFGIASDDKAGRQDALAFMQRACDAIGKLNKGLGRKAVKAIEIQTAPDRSka-eGSA-KSLQDSLETML-S-WDW 151
gi 81401951   75 VWDGGTFGLASPDDDGRNAAIAFTRSIIDSARALDDAAGHRVIAGIHIHSAPSVT----ANR-DQFLRSLTELLeG-MDN 148
gi 123586955  76 LAKDPHFGIASDNEAGRLNALAFYQQANAEIAKLNNHFNKQVVSHIQIHTAPAITpntsSSV-SALVKSLNELQ-S-WDW 152
gi 123089916  76 IGKNPNFGIASDDQAGREEALAFMAKARDAIAKLNAHCGKQVVTAIEIQTAPNRSva-hSSA-ESLKASLTTML-G-WDW 151
gi 807232151  81 LGSSPTFGLASPVAEGRQAAIDHALIAVERAHRLNDLTGQRTISTLHVHSAPSVT----AQE-DAFAQSLSEL--K-DRG 152
gi 504658495  73 LAEEPNFGLASTDDEGRRAAVEWVTGVRRAAEELNQQTGEETVSFVHVHSAPGVR----ASA-EAFQRSLADLE-A-DDG 145
gi 503538411  75 RADEPGYGLASHEPEHRALALGDVARARDLARTLADRHGRRRVAAIEVHTSPGPL----RGApDAFARSLEEIL-G-WDL 148
gi 501033440  91 LGTDPAYGLSSTDPGSRARALADLARARDLALSLAEGSGRRRVVGIELHSAPGPR----AGSlDALARSLEEVL-S-WDL 164
gi 506364527  84 LAADPRYGIASTDEDGRAVAVADVRRALDVARRAAELSGRQRVRAVEIHSAPRDG----GGS-ATALAASLAEL-LsVDG 157
gi 502629047  98 LADHPAYGLSSADLDARRAALDDLAELRDLAQRLSDDAGRPRLTAVELHSAPGPG----LGTlAAFRESLDEVL-A-WDL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123064531 152 HGADIVIEHCDALVPEHDHAKGFLSLDDEIAVINELnaa---nnaNLGLLINWGRSAIESMSTEGVLAHIEHVKAHGLLK 228
gi 81401951  149 DDPRLIIEHCDRYNEAVTGEKRFLSIEQEIAIAKET---------GIGITVNWGRSAMEAYDTQLPARHIQALVAEGVFE 219
gi 123586955 153 HGAKLIIEHCDAYIQNQSSEKGFMRIEDELLAIATVnkq---annKLGITINWGRSAIEAQSATGPLHHMQLCINENLLS 229
gi 123089916 152 QGARILVEHCDTFLTGQKPAKGFLTLREELAAINDVnqa---lgaNVGVVINWGRSVIETRSTRGALDHIEQAKAAGLLA 228
gi 807232151 153 LGLDLVIEHCDAYVPEYPGEKRFLTLETEARIAREL---------GLRVTVNWGRSVIESRDAGRPREHVEKLVAAGVLG 223
gi 504658495 146 FRAEVVIEHCDAYSPIFPGDKRFLSLITELAVADEY-----------GFAINWGSSALEWQNPNRPRQHVEILAEAGRLR 214
gi 503538411 149 AGAELLVEHCDAHVPGQAPAKGFLGLDEELAVVRSFglp----pdRLGMVVNWGRSAIEGRDTTTPVAHTRTVADEGLLR 224
gi 501033440 165 AGAGVVLEHCDALLPGATPAKGFWPLEEEIALVQGFglp----peRLGLGFNWGRSAIEGRGPALALEHVRTLAATGLLR 240
gi 506364527 158 AGAQLAIEHCDAARPGRRPEKGFLEIEDELAAIDAVdd------pRVGLTVNWGRSAIEGRSASTPEEHVALAASRGRLA 231
gi 502629047 172 GGARLLVEHCDALVDSQQAVKGFWPLHDELTVLQSLagdvpevasRLGLSINWGRSAIEGRSARTPVEHVRAAAEAGLLR 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123064531 229 GLMFSGVTDQDSPYG-IWKDTHMPAAKNST--VdfgaehSLLTEEEIHRSLAACGEALThdsIVGIKLGIrPKDAPLEPR 305
gi 81401951  220 GVMFSGAGDKENTFGaAWADLHLPHHVDEP--A------SLMDDDRIAECLSAAGGAQK---YHGAKIQA-PADVDVATR 287
gi 123586955 230 GLIFSGASSTSALYG-AWKDSHMPPVMNDF--DqlnnkdSELSEHQIKKCMQLQQSAKLd--FVGCKISIlPHQQPLASR 304
gi 123089916 229 GLMFSGVSDQDTEYG-AWQDTHMPAAKAAN--GtigaegSLMTEAEMHACMRAAGDVP----ILGIKLGVrPKDAPLEDR 301
gi 807232151 224 GVMISGAGGEDSVYGpGWADTHLPLVETEP--V------SWLTPDRVVECVEAARGHAs---YYGVKVQV-PPTSSVSER 291
gi 504658495 215 GLIFSGVAAVDTRWGrAWADLQLPLSTDEP--A------SLMTPRRVTECLDLAGDQVA---YLGARVKA-PANADVEAR 282
gi 503538411 225 LLVLSGATDADTAWGpAWGDMHIPPRGEDPalAas--saSLLGPSEIAATLAAAGDVP----RIGLKWAArPHDAGVAAR 298
gi 501033440 241 SVVFSGATGEESPWSpPWADTHIPPRGDDPalAvs--apSLLGVEEIAATLRAAGDVP----HVGLKVAVrPEDADVATR 314
gi 506364527 232 GLMFSGASAVAGVGGgAWEDWHVAPRGAGP--TpddwrdSLLDADRMRRTLAACAGTAPs--YVGMKVTAgPASRSVAER 307
gi 502629047 252 AVVFSGAAATPTPWGaAWEDQHIAPRADDP--AlrlsegSLLGAEEIAETLAAAQGSALd--VVGIKVTVrPDTADAQDR 327

                 ...
gi 123064531 306 VGY 308
gi 81401951  288 VTM 290
gi 123586955 305 IQY 307
gi 123089916 302 LGY 304
gi 807232151 292 LDI 294
gi 504658495 283 LGL 285
gi 503538411 299 VAL 301
gi 501033440 315 LAV 317
gi 506364527 308 VEI 310
gi 502629047 328 VAV 330
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