4I1L


Conserved Protein Domain Family
FOXP-CC

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pfam16159: FOXP-CC 
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FOXP coiled-coil domain
This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain
Statistics
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PSSM-Id: 318404
View PSSM: pfam16159
Aligned: 33 rows
Threshold Bit Score: 93.876
Threshold Setting Gi: 674593549
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
4I1L_A          9 LlaNGVCKWPGCEKVFEEPEEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQLELEKEKLGAMQAHL 76
gi 353233592  383 LiaGQVCDWPGCGAILGPDTSFIEHLNKTHQLSLQALAQVEVCASRLELYLRTVRKESQRLNAMVRHL 450
gi 674578262  169 dvgGGQCYWPNCCHVATSSTSLTAHADEAHDLTPETLAQLEMRIFELEMAYKKYTAESHLVRSMMDHL 236
gi 734635612  148 LfvSGLCRWPGCDAVSEDFPSFLKHLHSEHSHGDRSIAQWKIQQDIVQCMESQLILEKQKLIAMQLHL 215
gi 291278432  170 LfvSGLCRWPGCGAVSEDFPSFLKHLQSEHGRCDRSLAQWRVQQDIVQCLETQLVLEKQKLFAMQLHL 237
gi 941795059  116 LfvSGLCRWPGCGVILENFSTFLKHLHSEHRHNDKSIAQWRVQQDIVQYMERQLVLEKQKLLAMQLHL 183
gi 597785513  151 Ca-KGVCAWPDCKKVFKESTHFHKHLRSEHRPGDKTIEQWTKQSDNVKQIENQLILEKQKLRAMSLHL 217
gi 170046714   23 LfgSGACRWPGCERIFDNFDEFYNHLQSDHINGDYSAAQARIQMEVVCQLHLQLQKERDRLQAMILHL 90
gi 341900057   87 LwqHSMCAWPNCDQPCDSVMALIAHLQQEHPPCDRTNEEMRAQIEKVESLEHKLSVERNRLQGMMQHL 154
gi 393904703   65 LyqHNLCTWPQCDQPCENFATFLHHLATVHTLDERSAQQCRAQIEVVDNLEHRLNRERTRLQAMMQHL 132
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