Conserved Protein Domain Family
DUF4866

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pfam16160: DUF4866 
Domain of unknown function (DUF4866)
This family consists of uncharacterized proteins around 250 residues in length and is mainly found in various human gut Firmicute species and abundant in human gut metagenomic datasets. The function of this family is unknown.
Statistics
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PSSM-Id: 318405
View PSSM: pfam16160
Aligned: 40 rows
Threshold Bit Score: 354.561
Threshold Setting Gi: 81510754
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81510754     3 TI--FPKEQNVTPLFEQILANPTACRRFKDVFLDNLESYQETrGFEKDDTLFAKIILSAYRQSDVSALLLGVCGRTLFEL 80
24_pfamImport   1 -V--LPREEEVEAIFSQILASPDSCKKLMDVFYDAMDDNHLLe--TDNPKHFSKVLFYAYQNGDISALLLKLCGKSMFDL 75
34_pfamImport   1 TV--LPREEAVETIFSKILASPEASGRLSGVFYDHIDDDHRLt--DNDRDHFLQVLFHAYQNGDISALLLELCGRSMFDL 76
10_pfamImport   1 TV--LPREEAVEAIFSKIFESKEACGRLKDVFQEHLEEEN-Is--GDSAGHFAEVLFHAYKNGDVTALLLELCGRSMFDL 75
20_pfamImport   1 TI--LPREEAVEGIFSEILASPTACEQLRDVFYEHLDEEHGId--FDESEHFIQVLFNAYKNGDVTALLLELCGGSMFDL 76
gi 524091750    4 kiskIPREEAVEAIFSKIIQSPVACERLSETFYEHLNDDHLVvDS--NSERFAKILFSAYETQDISALLLEVCQKSMFDL 81
gi 524364891    3 sV--LPREEEVEAIFSQILASPDSCKKLMDVFYDAMDDNHLLeT--DNPKHFSKVLFYAYQNGDISALLLKLCGKSMFDL 78
gi 547882901    3 TV--LPKENEVEQFFSRIMASEGACERLSSVLYDHLSDDDMQt--DPDPKHLVQVLLTAYTNGDISALLLELCGRSLFDL 78
gi 524443550    7 TIkkIPKEEAVEQIFEKILSSPIACEKLSDVFYEHISMDNLTiDE--NSQRFTNILFSSYKTGDISGLLLELCQRSMLDL 84
gi 524770294    4 tlkrIPRETEVEEVFGKILQSPEACGRLEEIFYDRFSEENIS--PDTRSQHFAKALFSAYENQDISALLLEICQRSMFDL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81510754    81 LRQAFLIPKKLTVD---NPFFLTDKEGNFI-AKKDDISNREQEKFQEIYQSDLHhsETTIFLVDDDDIVHSY--EP--DF 152
24_pfamImport  76 LREAYLIPKRFHGKsgeNPVLLTNPEGELLpEAQKIVSGREYSKFKETYKNHICapRSKLYLADGYDIVRCY--VNdtDM 153
34_pfamImport  77 LREAYLIPKKFHGKageNPVLLTDAAGGLLpGEK--VSAREYAKFKETYEHHECapRSALYLADGYDLVRTY--TE--GL 150
10_pfamImport  76 LREAYLIPKKFHGKagaNPVLLTDVDGNLLqEKK--VSAREYTKFKETYEIHQCapRSKVYLADGYDLVRSY--EK--GT 149
20_pfamImport  77 LREAFLIPKKFHGKsgeNPVLLTDVDGNILeGKEKEISGHEYEKFKEIYDRHECapRSKLYLADGYDIVRSY--TK--GM 152
gi 524091750   82 LREAYLIPKRFYGKngrNPILLSDVEGKLLkDIKEPVSHHEYTKFKEIFENHVCapRSKLYLADGFDIARYY--TK--DM 157
gi 524364891   79 LREAYLIPKRFHGKsgeNPVLLTNPEGELLpEAQKIVSGREYSKFKETYKNHICapRSKLYLADGYDIVRCYvnDT--DM 156
gi 547882901   79 LREAYLIPKRFHGKagkNPELLTTPEGDVIeEKKKLVTKHEFEKFRDVYKNHSCapRSKLYLADGYDLMRVY--TD--GM 154
gi 524443550   85 LREAYLIPKRFHGKagkNPALLTDADGMLLkNIKSDISHHEFSKFQEIQKQHTLapRSKLFLADGYDIERTY--TD--NM 160
gi 524770294   82 LREAYLIPKRFHGKagdNPVLLTDVDGNKLeTGNRTISSHEWNKYQEILKNHVCapRSKIYLADGYDIVRRY--TD--DL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81510754   153 SISTKRINKKRGILVLYSLPDTLKSGMTESEVYAFIWKTFLHIQEIIPSSRIFYGQETSENA-------DELGVFLPIHH 225
24_pfamImport 154 EITEKRENKRRGIMILYALPDTKKIGLTEAQAYAVVWDTFHNIQKEAPHAIVYYGQETGLKKeq---tfDEIGILLPIRE 230
34_pfamImport 151 NITEEKDNRKRGVLALYALPDTCKLGLTEAQAYAVVWDAFQKIQEEAPRAMVYYGQETGLKKenpdkpyDEIGILLPIHE 230
10_pfamImport 150 KIVEKKENKSRGILILYALPDTCKMGLTEAEAYAVVWETFMQIQKAAPRAIVYYGQETGIKKqk---efDEIGVLLPIRE 226
20_pfamImport 153 ELVEKKDNRNRGILILYALPDTRKLGLTEAQAYAVVWDTFHKIQEEAPRAMVYYGQETGVKKdk---efDEIGILLPIRE 229
gi 524091750  158 EIEEKLENRRRGVMILYALPDTVKLGMTEAQAYAIIWDTFRMIQSVAPSAMVYYGQETGKKNqk---kfDEIGILLPIHQ 234
gi 524364891  157 EITEKRENKRRGIMILYALPDTKKIGLTEAQAYAVVWDTFHNIQKEAPHAIVYYGQETGLKKeq---tfDEIGILLPIRE 233
gi 547882901  155 NIKEKRVDKRRGVLILYALPDTVKLGLSEAQTYDVIWNTFHKIQQTAPTAMVYYGQETGEKAgk---sfDEIGVLLPVHQ 231
gi 524443550  161 EIDEKLANGKRGILILYALPDTAALGLKEAEAYAIIWDTFQEIQKCAPTAMVYYGQETGLKNeq---kyDELGVLLPIHQ 237
gi 524770294  158 DIKEDYVNPKRGIFILYALPDTAALGMSEAQAYAIIWDAFQQIQKCALSAMVYYGQETGLKNer---kfDEIGVLLPISQ 234
                         250
                  ....*....|....*
gi 81510754   226 FEKKMLQNIEQVNEL 240
24_pfamImport 231 FEKKMLHHLSEIDGL 245
34_pfamImport 231 FEKKMLQHLDEIDGI 245
10_pfamImport 227 FEKKMLHHLQEVDGI 241
20_pfamImport 230 FEKKMLHHLSEIDGI 244
gi 524091750  235 FEKRMLHHLEEIDGI 249
gi 524364891  234 FEKKMLHHLSEIDGL 248
gi 547882901  232 FEKKMLMHLSEIDGI 246
gi 524443550  238 FKNHMLHHLECIDGI 252
gi 524770294  235 FEKKILHHLTEIDGI 249
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