Conserved Protein Domain Family
Ferlin_C

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pfam16165: Ferlin_C 
Ferlin C-terminus
This domain is found at the C-terminus of proteins belonging to the ferlin family, including dysferlin, myoferlin, otoferlin and fer-1-like proteins.
Statistics
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PSSM-Id: 318409
View PSSM: pfam16165
Aligned: 8 rows
Threshold Bit Score: 158.415
Threshold Setting Gi: 309359037
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556947738  1807 PRFSIFRNKRMRGWWPFVK----------------LKSEEDEEKEE----------KEEKKKKEKKRKGKPEDFEYKDAS 1860
gi 1040658950 1695 PRFSIFRSKRMKGWWPLIK----------------LKSQEDIEREEreaeqekknkKKKKKKSSKRSQMKPEDLQFVDNS 1758
gi 941808949  1865 PRFSIFRAKKMKGWWPLVR----------------LKTAEDFEREEkekmdakkkgHKKKKTKDKRSQMSKEDIQYTDSL 1928
gi 309359037  1969 DTVNIFEARNLYGWWPMLTdeyphvsceskqlqncIKIQEE---------------PQNAKKKNDDIGKDPKWIM----- 2028
gi 973138848   946 TS-SIFKKKREKGWWPFTK----------------VKEAEEEEEEK----------ENDNKTKKKKKEKERETVTVGTGS 998
gi 568918675   963 PRCNLFRCHRLRGWWPVVK----------------MKDMEDVEREAre-------aQAGKKRKRKRRAGRPEDLEFTDTG 1019
gi 611975365  1832 PRCSLFRSRRVRGWWPFVK----------------LREPEDLEREKqe-------aEGRGKKKKKRRKAKPEDIEFTDSS 1888
gi 565306777  1843 PRFSIFRNKRMKGWWPFIK----------------LKGQEDIEREErea-----kqKKKKKKKKWRRSVKPEDVEFSDPS 1901
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556947738  1861 GNTYILT-GKVEAEFQLVTVEEAEKSPVGLGRKEPEP---LELPNRPKTSFNWFLNPLKTFIYFIWKNYK-KYIIALLII 1935
gi 1040658950 1759 GNTFLLM-GKVEAEFHLVTPEEAEKNPVGKARKEPEP---LDKPNRPKTSFNWFVNPMKTFVFFIWKKYK-KYIIALIIL 1833
gi 941808949  1929 GNTYLLM-GKVEAELQLVSLEQAEANPVGRGRKEPEP---LEKPNRPTTSFNWFINPMKTFVFLIWKNYK-KYIIALVIL 2003
gi 309359037  2029 --------GLVEMDMMLLTKQEADQEPAGKKRAEPNHspfLEKPNRKTWANSWLVSRIKPCIKYFWHYYGlQILLWILII 2100
gi 973138848   999 SAYILELtGKVEAEFELLTSEEAEKHPAGEGREEPQP---LEKPNRPTVSMSWIVNPFKTLYFFIWRNYK-WYIIFSLLG 1074
gi 568918675  1020 GNVYILT-GKVEAEFELLTVEEAEKRPVGKGRKEPEP---LEKPNRPKTSFNWFVNPLKTFIFFIWRRYW-RILVLLLLL 1094
gi 611975365  1889 GNVYILT-GKVEAEFELLTVEEAEKHPVGKGRKEPEA---LEKPNRPKTSFNWFVNPLKTFAFFIWRRYW-HILVLLLVL 1963
gi 565306777  1902 GNIFILT-GKVEAEFQLLTIEEAEKNPVGLGRKEPEP---LEKPNRPKTSFNWFVNPMKTFIFFIWKRYK-KYIIALLII 1976
                          170       180
                   ....*....|....*....|..
gi 556947738  1936 AILALFLALILYTLPGEISKQI 1957
gi 1040658950 1834 VILGLFLGLILYTMPSHISQLI 1855
gi 941808949  2004 IILTLFLVLIVYTLPGEISSLI 2025
gi 309359037  2101 ALLALTIFALIQTWPIILVEif 2122
gi 973138848  1075 VSVTSFLVMLVYTFPGNITNKl 1096
gi 568918675  1095 ALITIFLLLVFYTIPGQISEVI 1116
gi 611975365  1964 ALLTIFLLLVFYTIPGQISKVI 1985
gi 565306777  1977 AIVTIFLVLILYTMPGYISEKI 1998
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