Conserved Protein Domain Family
CENP-T_N

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pfam16171: CENP-T_N 
Centromere kinetochore component CENP-T N-terminus
CENP-T is a family of vertebral kinetochore proteins that associates directly with CENP-W. The N-terminus of CENP-T proteins interacts directly with the Ndc80 complex in the outer kinetochore. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes. This family represents the N-terminus of CENP-T.
Statistics
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PSSM-Id: 318414
View PSSM: pfam16171
Aligned: 13 rows
Threshold Bit Score: 355.336
Threshold Setting Gi: 345317037
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503732   1 MADLSFSDGDPTVRTLLRRVLETADSRTPM----RRRS--------------------------TRIN-AQRRRSQTP-Y 48
gi 81909300    1 MADLSSPDGDPTIRTLLRHVLDTADSHTPR----RRQS--------------------------TQTN-PQRRRSQTP-Y 48
gi 831241967     --------------------------------------------------------------------------------
gi 345317037   1 MASL--PEDDLTTRTLLKRVLATEPPHTPLpvpgHDRKpkletrrrslrlsgpplpppetpatsSPSM-TLRNRMKER-V 76
gi 675752122   1 MAD-HNPDSDSTPRTLLRRVLDTADPRTPR----RPRS--------------------------ARAGaQRRALLETA-S 48
gi 694964049   1 MAD-DNPDSDSTPRTLLRRVLDTADPRTPR----RPRS--------------------------ARAG-ARRALLETA-S 47
gi 311257132   1 MADSHSPDSEPTTRTLLRRVLDTADPRTPR----RPRS--------------------------ARIG-AQISPLETS-S 48
gi 625202945   1 MAGRYSPDPDQTPRTLLRRVLDTADSRTPR----RRQS--------------------------VRNN-AQRSLLQIPsS 49
gi 914898867   1 MAD--NWDSEPTIRTVLQRVLDNADSRTPR----RPRS--------------------------SGAG-AQRTLLTTS-S 46
gi 731501917   1 MADSKSSDSEPTTRTLLRRVLDSAVPRTPL----RPRS--------------------------ARTS-AKRALLETP-S 48
gi 149699237   1 MADSGSPDSEPTTRTLLRRVLDTADPSTPR----RPRS--------------------------ARAG-AQRALLETP-S 48
gi 587015090   5 MADSYSQDSEPTTRTLLRRVLDTADTRTPQ----RRRS--------------------------AGIG-AQKSLLETP-S 52
gi 511839999   5 maerynRDSEPTTRTLLRRVLDTADTHTPR----RRRS--------------------------ARIG-AQKALLETP-S 52
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503732  49 SNRQGSQTKTSARKQSHGARSVGRSTRVQGRGRLEEQTPRTLLRNILLTAPESSTVMPDPVVKPA--------QVPEVAR 120
gi 81909300   49 SKRQGSQRKTSTRKHSHGTGSVGRLARVQGHGHLEEQTPRTLLQNILLTAPESSTVMPNPVVKPA--------QVPEVAR 120
gi 831241967   1 --------------------------------------------------------MPESVAKPV--------PEAQVAQ 16
gi 345317037  77 RRSMRITRASSSRPPESQASSRPAPPR---RDKMDEETPRTILRNIMQTAPEASMLVPNS---PA--------PAVEEVQ 142
gi 675752122  49 SRRLSSQTKMTTRRYSHGVRSISGSAYVQASGHLEEQTPRTLLKNILLTAPESSILMPKSVVKPV--------PAPQEVQ 120
gi 694964049  48 SRRLSGQTRTIARGRSHGARSIGRSAHIQASGHLEEQTPRTLLKNILLTAPESSILMPESVVKPV--------PARQVVQ 119
gi 311257132  49 SRRLRSQTKMSARRRSHRIRSIDRLAHIQASGHLEEQTPRTLLKNILLTAPESSTVMPESVMKPL--------TVPQMVQ 120
gi 625202945  50 SKRQSSQTKIVARRHSYITRSVVRLARVQTHGHLEEQTPRTLLKNILLTAPESSIVMPDSVVKPV--------QVPEMVE 121
gi 914898867  47 SRRLSSRTKTSAKQRSHGVRSIGRLAHIQVIGNLKEQTPRTLVENILITAPKSSILTPEAMVKPV--------PALQVVQ 118
gi 731501917  49 SRSLSSQRKVTARRQSHGARAIGRWAHVQARGHLEEQTPRTLLKNILLTAPESSIVMPESVVMPVvqpsrrstSGPQVVQ 128
gi 149699237  49 SRRLSSQTKTTARRRSQRIRSIGKLAHVQASGYLEEQTPRTLLKNILLTAPESSIVMPKSVVKPG--------PAPQVVQ 120
gi 587015090  53 SRRLSSSTKTNARRRSQRARSIGRLAHVQTSGHLEEQTPRTLLKNILLTAPESSIMMPESVVKPV--------PTPQVVQ 124
gi 511839999  53 SRRLSTPTKMNVRRGSHRARSIGRLAHVHTSGNLEEQTPRTLLKNIILTAPESSIMTPKSVVKPV--------PTPQVVR 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503732 121 SSRRESSRGSLELHLPELEPPSTLAPGLTAPGKRKQKLRLSVFQQEVDQGLPLSQ----------EPRrsRSADVSSLAS 190
gi 81909300  121 PSRRGSSRGSLELQLPELDPPSTLAPGLKAPGKRKQKLRLSVFQQEVNQQLPLPQ----------EQR--GAADGSSLAS 188
gi 831241967  17 PSRRKSSQGSLELQLPEPEPPAPLPQGLLAPGKRKQRLRLYVFQQGVDEGLPLSH----------EPR--GNPDASSLAS 84
gi 345317037 143 P-LQESRQSSLDLQLPELEPLMPMARAQLGTGRKRRKLRLSEFERGVDQGLAASVgapsltipaeEPL--ASANTSSLTK 219
gi 675752122 121 PSRRESSVGSLELQLPELEPPTTLAPGLLAPGRRKQRLRLSMFQQGVDQGLPLSQ----------EPQ--RNDDASSLTS 188
gi 694964049 120 PSRQESSCGSLELQLPELEPPTTLAPGLLAPGRRKQRLRLSMFQQGVDQGLSLSQ----------EPQ--GNADASSLTR 187
gi 311257132 121 PSRRESSWSSLELQLPELEPPTTLAPGLLASGRRKQKLRLSVFQQGMDQELPLSQ----------ESR--GNADASSLTS 188
gi 625202945 122 SSKWESSPGSLELQLPELEYPSTLAPGLPATGRSKQRLRLSVFEQEVNQRLPLSQ----------EPP--GNADASSLTS 189
gi 914898867 119 PSRRESSQGSLELQLPELEPRTTLAAGLPASDRKKQRLRLSVFQQEVDQGLPHLQ----------EHP--ENADAPSLTS 186
gi 731501917 129 PSRRESSRGSLELQLPELEPSRTLAPGLLASGRKKQKLRLSVFQQGVDQGLPLSQ----------EPH--GNADASSLTS 196
gi 149699237 121 PSSRESSRGSLELQLPELEPPTTLAPGLLAPGRRKQRLRLSVFQEGMDKGLPLSQ----------ESR--GNADASSLTS 188
gi 587015090 125 SSRQESIRGSLELQLPELEPPTTLALGLLAPGRRKRKLRLSVFQQGIDQGLPLSQ----------EPC--GNTSASSLTS 192
gi 511839999 125 SSRQESSRGSLELQLPELEPPTTLALGLLAPGRRKQRLRLSVFQQEMDQGLPLSQa---------EPR--GNASASSLTS 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503732 191 -SFNLTFVLPGQPETVERPGLARRRPIRQLVNAGALLQDLEDNSLASALPgdshrtpvaalpmDVGLEDTQPFSQSLAAF 269
gi 81909300  189 -SFNLSFVPSVQPQTVDRPGLARRRPVRRPVNIGAFLQNLENKSLTSALPgdshrtpvaalptDVVFEDTQPFSQPLAGC 267
gi 831241967  85 -SLNLTFATPLQPQSVHRPGLARRPPTHRSVDVAAFLQDLRDTNLA--PP-------------NIVLEDTQPFSQPLAGC 148
gi 345317037 220 -SFNLSLTALVLPESVKRPGLARRPRTRKAISLEAFEQGLEKTPLPTQ-EaaqaasadswvvaDTLLGDTQLFLQASPWD 297
gi 675752122 189 -SLNLTFATSLQPQSVQRPGLARRPPARRAVDVGAFLQDLRDTSLA--PP-------------NIVLEDTQPFSQPTVGC 252
gi 694964049 188 -SLNLTFATPLQPQSVQRPGLARRPPARRAVDVGAFLRDLRDTSLA--PP-------------NIVLEDTQPFSQPMVG- 250
gi 311257132 189 -SLNLTFATPLQPLSVKRPGLARRPLTRRAVDVGTFFQDLRDTSVALPPP-------------DTVLEDTQPFSQPLAGH 254
gi 625202945 190 -SFNLSFVPPCQSQSVGRPGLARRRPIRRPVDVGVLLQDLEDNSLTTALPgdnyrtpvatlptDAVLEDTQPFSQPSVGC 268
gi 914898867 187 -SFNLTFATPLKPQSVRRPGLARRPPRPRAIDVGALLQDLQDNSLAp---------------sDTVLEDTQPFSQPLVGC 250
gi 731501917 197 tSLNLNFATPLQSQSVGRPGLARRPPTRRAVDMGAFLQDLRDTSMALVSPgdshrtpiatlqkDAVLEDTQPFFPPLVGR 276
gi 149699237 189 -SLNLTFATPLQPQSVQRPGLARRPPTRRAVDVGAFLQDLRDTSLALAPP-------------DTVLEDTQPFSQPLVGR 254
gi 587015090 193 -SLNLTFATPLQPQSVHRPGLARRPPTRRAVDVGALLQDLQDTSLALASPgnslrtpvatlptDTVLEDTQPFSQPLVGH 271
gi 511839999 194 -SLSLTFASPLQTQSVQRPGLARRPPTRRAVDVGAFLQDLRDTSLALASPgdslrtpvatlptDTVLEDTQPFSQPLVGH 272
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503732 270 SLSGKHSLPSPSRPGVEDVERVMGP--PSSGTRLQSRM---------------SRS----------GPAASPSPFLEP-- 320
gi 81909300  268 SLSVHHSLPNPSQTEVEDAERVVGPrtPSTGTRPQSQM---------------SRA----------GFGASPLPFSEP-- 320
gi 831241967 149 SPSMHGSQPLPSHTGAEDTERVASPrtWSSGSRLQNSS---------------PEKpaqflarkakEVNALALGFPNTsn 213
gi 345317037 298 QSRPHHSQVQPAGEGKQDPDKADAHqtRSPSSAASRLS---------------PAR----------QVDG---------- 342
gi 675752122 253 SRRVYRSLPCMPHTGAKDAELAAGCktRSSGPGMQTNS---------------PEKpaqflageaeEVDAFALDFLSTss 317
gi 694964049 251 SPHVYHSLPCTPHTGAEDAEQAAGRktQSSGPGLQKNS---------------PGKpaqflageaeEGDAFALGFLSTss 315
gi 311257132 255 SPSVRHSLPCPPHSGAKELERADSRrtLSGGPGPQNNG---------------PGEpaqllagkveEAAAAAVGFPNAss 319
gi 625202945 269 SLRVYHSLPSPSHSEVKGAERVVGRrtQSTGTGLEKHM---------------SRT----------SLGTTPLPFSKL-- 321
gi 914898867 251 SPSVHRSLPNPFPTGTEDAERTTGDrtQSSGPGLQNH------------------------------------------- 287
gi 731501917 277 SPSTHCSLPGPSHTGAVHAERAVGRrtWS-GPGLQNNSpekptqllagravevKALa--------vGFPNTSSGISGE-- 345
gi 149699237 255 SPSVHHSLPCPSHSGAEDAERAVSHrtRSTGPRLQNNS---------------PGKpaqll-agkaEVDALAMNFPNTss 318
gi 587015090 272 SPSVYHSLPCLSYTEAKDAEKAVSHrtQRSGPKLQNHS---------------PVKpaqllagkskKVDALAMSFPNTss 336
gi 511839999 273 SPSVYHSLPFLSHTEAENSERAVSRrtQSSGSRLQNHN---------------PGKpaqllagkakKIDVLAVSLPNNss 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503732 321 ----------------------------------------------Q--------------------------------- 321
gi 81909300  321 ----------------------------------------------Q--------------------------------- 321
gi 831241967 214 sisgdaveplqdgvgeeaekkmeeeeglsmsevkettgsqgpfraeQ--------------------------------- 260
gi 345317037     --------------------------------------------------------------------------------
gi 675752122 318 gvsgedgveplqdgveeaekr--meeegvsvsemeatgaqgpsraeE--------------------------------- 362
gi 694964049 316 gvsgedeveplhggveeaekk--meeegvsmsemeatgaqgpsrveE--------------------------------- 360
gi 311257132 320 sisgedgveplqnrvgeeaeer-teeswsmreveeaagaqgsaragE--------------------------------- 365
gi 625202945 322 ----------------------------------------------Q--------------------------------- 322
gi 914898867     --------------------------------------------------------------------------------
gi 731501917 346 ----------------------------------------------Dgveplgdavdeqaeermeegglsvseakeatgt 379
gi 149699237 319 sifgevgveplqdgvggeaeer-tekslsmskvkeaarargsaraqE--------------------------------- 364
gi 587015090 337 aiagedeveplqggvgenaeer-meeslsvsevkdttgtqgsvrtdK--------------------------------- 382
gi 511839999 338 aisgedgveplqdgvgeeaeer-meeslsvsevmgstgtqgsvrteK--------------------------------- 383
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115503732 322 --------PPP-AEPREA-VGSNEAAEPKDQEGSSGYEETSARPASGELSSSTHDSLPAEQP 373
gi 81909300  322 --------PQS-PELREA-VGSKEAEEPKDLEGSSGDEETSGMPASRELSSSAQDLLLAEEP 373
gi 831241967 261 --------PGGhTEVTES-EGFQGAVETEEPEESKGDEDISGRTACPELASNTPAFLQTKQR 313
gi 345317037 343 --------------ASRSlDGAQvsrqslgirhsarftptrnkdireagaepghrsgmelaa 390
gi 675752122 363 --------PEGhTQVIEA-EESQETAEAKGPGASSGDEDASDRAASPELVSSTPESLQARRH 415
gi 694964049 361 --------AEGhTEVTEA-EGSQGTAEADGPGASSGDEDASGRAASPESASSTPESLQARRH 413
gi 311257132 366 --------PEGhTEVTEA-EGSWGAVEAKEPEGSSEDEDTSGRTASPELASSTPEFLQARRL 418
gi 625202945 323 --------PQP-PEIREA-VGSQEAVEAKEQEGSSRDEDTPGRPASPELAADTYNLLQAEQP 374
gi 914898867 288 --------------IMEA-EESQETMETEEPEGSSEDENTSDRPASPQLASSTPRFLQAKRL 334
gi 731501917 380 qgsagveeSEGhTEVTEA-DGSAGAVEAKEPGGSSGDKDTSNRTASPQLASSGPKSLQARRL 440
gi 149699237 365 --------PEGhTQVTEA-EGSQGAIETKEPEGSSGDCPTSSRRVSPELASSTPEFLQAKRI 417
gi 587015090 383 --------SDr-NETSEA-------VEAKEPEGSSGDENISGRTASPELASSTTEFLQARQL 428
gi 511839999 384 --------SKGhGEMTEA-------LEAKEPEGSSEDEDISGRTASPELASSTTEFLQARRP 430
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