4J8S


Conserved Protein Domain Family
CNOT1_TTP_bind

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pfam16417: CNOT1_TTP_bind 
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CCR4-NOT transcription complex subunit 1 TTP binding domain
This is the TTP binding domain of CCR4-NOT transcription complex subunit 1. It adopts a MIF4G (middle portion of eIF4G) fold.
Statistics
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PSSM-Id: 318599
View PSSM: pfam16417
Aligned: 35 rows
Threshold Bit Score: 177.049
Threshold Setting Gi: 471231063
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4J8S_A          19 NQPTFQQ-----TDLSQVWPEANQH--FSKEIDDEANSYFQRIYNhpphPTM------SVDEVLEMLQRFKDSTIKRERE 85
12_pfamImport    4 KPPPVTQmqmmsNLPDLSPSDGQQM--YSNDVQEEVNGYFRQVYAhadaNGI------TVENFLEILRRCRDSKDKREKE 75
25_pfamImport    4 QQPSGGSpgritVPPAPMDDLTSVQ--FSEEIQNEANMYFQQIYSq--hMQM------PVADFVERLKQFKASNVQRDKD 73
gi 121973903   821 RQKLQDQykeilQYFPQLSGTSDSP--G-QATEKKANYNYQRFYM----REI------TIEEMIANLKQLMNSNNSEDKE 887
gi 471222381   437 RQKLQEQykiiiECFPQLNGRINPQ--I-QQIEKKANTQFQQLYS----KEI------SIEQFIDNLNNLRKSNIKEDNE 503
gi 471223964   322 CMKLQEQyqfiiECFPQLNGRSDPQ--V-QQIEKKANFYFQKLYS----KEI------TIDEFIENLKILNSSPSKEDNE 388
gi 470326531   759 qqqqqqqqqlqqqqqqqlDSSLSDGatYPPDVQAEATGELQQVFK----GSM------SVERFVDRVKLLKSSAFPRDQM 828
gi 350645423   987 NFNISIPmehppMELSFVNEPIKIQ--LSKEAEAEANTFFQKLLE----GIN------PPDEMFKTLYDFATQGTPSQRK 1054
gi 157868926   588 aSPLKEVlksvtDCAKALLASTDSL--FPDDVENEALEFFKKMYA----AGStaaaiaTVENLLK-------STVPRDKQ 654
gi 471231063   230 INKVFKQykeimEILPPL----DLQ--IFSEAESRTESLLNKLYQ----EEI------QCEYIIEALQQTKFSDKEEEKD 293
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4J8S_A          86 VFNCMLRNLFEE-YRFFPQYPDKELHITACLFGGII--EKGLVTYMALGLALRYVLEALRK-Pf----gSKMY-YFGIAA 156
12_pfamImport   76 VASCMLKNLFDE-YRFFNEYPEQELMKTGQIFGGVL--RDNLVTGITFFFGLRIMVESLRR-Gp----gTKLY-EFGLTM 146
25_pfamImport   74 ILACVVKNLFEE-YRFFHEYPERELRTTAEVYGSII--REGVISNLQFATAVRKVIESLQA-Ep----gSMLW-TFGIVA 144
gi 121973903   888 VFACMITSLIEE-AKYHQQYPIAELLLTGQLQGSII--NAQLVNQKPLGIMLEQILESSKK-T------QRQV-EQSVKA 956
gi 471222381   504 VFACMITGLLEE-CRFHDQYPYSELIFTGQLFGAII--NAQLIFQKPLAIFLEIVLDYCKRn-------NKKI-EFSIKA 572
gi 471223964   389 VFACMITGLLEE-CKFHDQYPFNELLFTGQLFGAII--NADLINNKPLSIVLDIIVEYCKKn-------NKKN-EFSVKA 457
gi 470326531   829 VLNCLIKELYSE-YLHLPRYGDETLTIAGRLYGSLL--SERVVSGVVGASFLKFILEGLRK-Ps----dSRLFvRFAIVG 900
gi 350645423  1055 LLDGILRMLADEvSRHLQDYPETMLPLFADLYGSVLaaSTHLFSMRALSMLWRSVLARLFTlPpethmdSTLF-RAMIHI 1133
gi 157868926   655 LYACIVGIMFDE-TSAISCYPRKELQLFAELYGQMI--AKDLLPPNQQQRAWGVLLPAVAK-Pg----nYAME-EYGIIA 725
gi 471231063   294 FFATFITILIEE-SKFYENYPEKQLVIAGKLYGSII--REDLVQGQPLGIMLKIIIECSKK--------IKKL-DFSISA 361
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
4J8S_A         157 LDRFKNRLKDYPQYCQHL-ASISH--FM-QFPHHLQEYIEYGQQSRDPPVK 203
12_pfamImport  147 LRCFKSRLKDYPRYCLTImSQVPH--FS-QFPVMLREYVAAGSKGNDPFPL 194
25_pfamImport  145 LNACRTKLSLYPKVCVMI-ANQRN--FQ-HFPQNLKDYVTSGIQGQQPHVP 191
gi 121973903   957 IEAMKDRLHEFPYFVNALfDPSCH--LSeQFPQLLINIYNIMIEKKVQINv 1005
gi 471222381   573 IDGMNDRLYEFPNFIYGL-FDSQI--LL-FYPDFLLKIVENCYKKGIifnn 619
gi 471223964   458 VEGMKDKLFDYPKFIVQL-FDSLL--VQ-KNPDLLMKIIEVNQkkkkkkkk 504
gi 470326531   901 LDCIKSRLAEWPQFALKI-VEIPH--FL-RFPPELVQAVRNSLQQGASASd 947
gi 350645423  1134 LMKAKNTFVHFSNLPNCL-ASCPV--FK-AFPHDLQGYILNSELAVKNYAL 1180
gi 157868926   726 LEQVKPRLPDWPQYGRAL-RYVRD--LD-FRVPGIVAAINRGIKQEDAAAR 772
gi 471231063   362 IEQMKEKIFNYPQFIQKI-IDIKSqiIE-KNPMFVFNLYHqqqqqqiqqqq 410
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