2YLF


Conserved Protein Domain Family
KIND

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pfam16474: KIND 
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Kinase non-catalytic C-lobe domain
The KIND domain (kinase non-catalytic C-lobe domain) evolved from a catalytic protein kinase fold and functions as an interaction domain. In SPIRE1 (protein spire homolog 1) this domain interacts with FMN2 (formin-2).
Statistics
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PSSM-Id: 318636
View PSSM: pfam16474
Aligned: 16 rows
Threshold Bit Score: 240.679
Threshold Setting Gi: 780074395
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YLF_A        33 LSLEEILRLYNQPINEEQAWAVCYQCCGSLRAAARR-RQp--------------rHRVRSAAQIRVWRDGAVTLAPA-AD 96
gi 123889259  36 LCLEEILTLYSQPINEEQAWAVCYQCCRWLTQKHRR-KEtgv----------sppGRIAGPGDVRIRKDGNVKLYQP-SN 103
gi 260797952  18 FSLEEILRAFGAPINEEQAWAMCYQCAKSLQDDWRRcRKe--------------cFQFTGGESVALRKDGSVGAVRT-ES 82
gi 91082899   15 VCLEDILNSFNSSIREEHAWALCYQCAKYYSECVSS-RKqn-------------vHIVTEVRHVYLQTDGNVHENTI-KA 79
gi 780074395  17 ISLQDILEAFSAPLNEEQAWAICYQCGKFLDESLDR-N-----------------VTVEGANGVLLSNDGTVRLMFA-ID 77
gi 768921230  41 LSLEDILRLYSQPINEEQAWAVCYQCCRTLAKEQRG-RRrssaaattgassaalpRRISGPGDVGIQKDGSVRVEHQ-DC 118
gi 307207707  45 LNLQDILLIFDSPVSQERAWALCYQTAKSLSNSTQNk-----------------fYEISEYSHIVLHKDGNVQLDSL-AG 106
gi 765123483  34 LSLEEVLKSYEQPINEEQAWAVCYQCCRGLRVPHPP-PGr--------------aDRVKDPSSLLLYRDGTVALRPN-DV 97
gi 924182584  21 LSLEKVLKSYEQPINEEQAWAVCFQCCGDLRAPRPQ-PHprh-----------peLQIRDPASIILHRDGRVTALLQ-SC 87
gi 768933442  41 VSLEEILNLYNQPINEEQAWAVCYQCCRTLAQIQRR-KSlksaga----saidypRRIEGAGDVMIWRDGTVKLHFSgSA 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YLF_A        97 DAGEpppvagklGySQCMETEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEA--DG---------SN-- 163
gi 123889259 104 PDKH--------T-PPSSSIEIIESLGIMIYKALDYGLKEHEERELSPPLEQLIDLMTNMADTe-TD---------CP-- 162
gi 260797952  83 SG------------PARFESQLVYSLGLVVYRALDYGLSESEERELSHPLEDLIDRMTSNDND--Ds--------qNH-- 138
gi 91082899   80 RDTPr------kL--LRCEKDVIAGLGVVIYIALDQGSQNDEERVISQDLEQLISDMISDELNssEQth-----heTD-- 144
gi 780074395  78 TDADh---------TRETQTVVMNTLGRTIYQALDYGLSEEEERELSRPLEELIEFMIGADRN--EHse-----nsNDnn 141
gi 768921230 119 E--G--------KySPCTTTEVIESLGIMIYKALDYGLKENEERELSTPLEELIAFMTNMVEAerDA---------CP-- 177
gi 307207707 107 SKQ-----------PLVSEEKAVLSLGMVIFKALDFGSNAEEEIALSPDLEALITLMTNCTRT--SEgdvegrlqeTD-- 171
gi 765123483  98 -ADKp------pF-PPTAECELVQSLGVVIYQALDWGLDDSEERELSPQLERLIEKMVAGVQE--EGvrst-tknsTS-- 164
gi 924182584  88 DDSNa-------GcESAADGKLVQSLGVAIYRALDWGLDDSEERELSPQLEQLIEFMVGGPDC--GQskhc-gsnaAK-- 155
gi 768933442 116 DTHTsppt----------sleVIDSLGVMIYKALDYGLKENEERELSPPLERLIDLMTNTGDTesDP---------CP-- 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YLF_A       164 -------------DEGYEAAEEGLGDE-DEK------------RKISAI----RSYRDVM--------KLCAAHLP--T- 202
gi 123889259 163 -------------DEGYEATEEEDEGE-EEN------------AEVSNV----RGYRDII--------SLCLSHLP--S- 201
gi 260797952 139 -------------DEGIEDSDEEITSE-DTV------------KTLEQVvkisQGFHDLLgtlalkevKLCASHLQ--N- 189
gi 91082899  145 -------------DEGIERDSEEGEEE-PGT------------SRTQPH----MTLQEVI--------RRCESHLGtlT- 185
gi 780074395 142 nvglrqeadsfnvDEGIEDEELCDEEP-DGErgrddarsedhvRVENES----CMITQLL--------KLCSDHLP--Q- 205
gi 768921230 178 -------------DEGYEATEEEDEME-DES------------DS--IP----SGYRDIL--------QLCTSHLP--A- 214
gi 307207707 172 -------------DEGIERDSGDTDAD-DDMmskt-----aepYTGSSV----CTLKTVL--------QICARHIQ--Nl 218
gi 765123483 165 -------------DEGYSGQEEEEEEQ-QQE------------GTTRPV----CTFRQVM--------ALCASRLA--N- 203
gi 924182584 156 -------------DEGYSGQDEEEEEEeEEE------------GAGRGI----HTVQQVM--------TMCASRLA--N- 195
gi 768933442 175 -------------DEGYEATEEEDECE-EEEepvl----attgSSVSSV----RSYRDIL--------TICSSHLP--S- 221
                        250       260
                 ....*....|....*....|....*..
2YLF_A       203 ESDAPNHYQAVCRALFAETMELHTFLT 229
gi 123889259 202 PSDAPNHYQAVCRALYAETKELRTFLE 228
gi 260797952 190 PSEAAGHYQAVCRALVAECQELTSFLA 216
gi 91082899  186 KTQTEAHYKAVVRALVAEALELATFLE 212
gi 780074395 206 PKAASTHYQAVCRAVYTEYLDLATFLN 232
gi 768921230 215 LSDATSHYQAVCRALYTETRELHTFLE 241
gi 307207707 219 HEDIDTYYQNVIQTFVEEALSLSQFLE 245
gi 765123483 204 PSVAPEHYQAVCRALFVETLELQTFLT 230
gi 924182584 196 PVLAPEHYQAVCRALFLETLELQTFLS 222
gi 768933442 222 PSDAPNHYQAVCRALFAEARELCTFLE 248
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