3TEQ,3TER


Conserved Protein Domain Family
SOAR

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pfam16533: SOAR 
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STIM1 Orai1-activating region
SOAR is the Orai1-activating region of STIM1, where STIM1 are calcium sensors in the endoplasmic reticulum. As the store of calcium is depleted the calcium sensor in the ER activates Orai1, a Ca2+-release-activated Ca2+ (CRAC) channel, in the plasma membrane. The SOAR region, which runs from residues 340-443 on UniProtKB:Q13586, forms a dimer, and is essential for oligomerization of the whole of STIM1.
Statistics
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PSSM-Id: 318685
View PSSM: pfam16533
Aligned: 29 rows
Threshold Bit Score: 112.304
Threshold Setting Gi: 514693448
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3TEQ_A         1 PEALQKWLQLTHEVEVQYYNIKKQNAEKQLMVAKE---------GAEKIKKKRNTLFGTFHVA--HSSSLDDVDHKILTA 69
1_pfamImport   1 --ELALLLQMTHELELRHYWEKRSAAAKQLMAAKE---------ACDRVRRKRSSLVGSVRLI--HSDNLDDVDSKLNAA 67
3_pfamImport   4 PEELAQWLHITYTKESRHFQMKRTQALKQMTEAKD---------ACDRIRKKRNSFIGSFRMA--HDLTIDEVDQQILAA 72
gi 340377927 363 rLALKQLLIETCLQEKYYLDANKRTAENEVMRAQK---------MCDKIKRKRASVIGAFRLA--NSSTLEDAGLMITKA 431
gi 402587958  74 PLALQPLLRRTCELEVSYVGQQRMECIAEMREAIE---------HIDKLRKKQSSLVSSIKLAtgASSGTDHIDSRIFAL 144
gi 341891937 287 PLALQPLLRRTCESEMAFLEKQRQDCFKEMKEAIE---------MVDKLQKKQGSVLSSLKLAtgASSTSDQVDSKIFAL 357
gi 954366712 316 lPMLRQLLIKTFELEFSRLNQEKIDNLKEMQEAREwlelcllsiKVEKLRKKHSSLLSQIRSV--HGSESEQIDRRLLNL 393
gi 313235632 282 TSDVKELLHRTYKAEKHNLDYRKRDARKKEHVATE---------NMKKLERANTSFFSSVRLL--HSHQLDHLDAALMQA 350
gi 470361017 407 SDELRILLQRTFAIEMQQHTIRRQSAELELKAAHE---------ALENVTRKNKNFMGSFRVA--HGGSLDSLNDAVHSA 475
gi 198428762 336 PTRLLTCLKTTYQVEMKLHEVKRHTAHKKVEQAKA---------QFQKMKKK-VSIFSSVQFI--HSRQVDSFDLEVQAA 403
                         90       100       110
                 ....*....|....*....|....*....|.
3TEQ_A        70 KQALSEATAALRERLHRWQQIEIL--TGFQI 98
1_pfamImport  68 RRVLENVTADMQERKHRWSRIEDL--TGL-- 94
3_pfamImport  73 RAALADVTNEMEERQRRWYQIEAL--SGLPI 101
gi 340377927 432 VNKMQMVTEHFESFQKRWQSIEQI--FGFPI 460
gi 402587958 145 KARMEKISLAMSECHQRWTEIESL--CGFPL 173
gi 341891937 358 KTRMEKIHTLTRETQERWMQIESL--CGFPL 386
gi 954366712 394 KQKMERTACSLEEQQQRWSRIELL--CGFSI 422
gi 313235632 351 HNAIEDIVRSQKESHDRWRKLEKI--FSIAI 379
gi 470361017 476 LQTLSHMRKESEEMSLRWQQIEDV--LSVTV 504
gi 198428762 404 KDALREIQRDSHEHRKRWMELETIlrCKFSs 434
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