4NAD


Conserved Protein Domain Family
CREPT

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pfam16566: CREPT 
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Cell-cycle alteration and expression-elevated protein in tumor
CREPT (Cell-cycle alteration and expression-elevated protein in tumor) is a family of eukaryotic transcriptional regulators that ptromote the binding of RNA-polymerase to the CYCLIN D1, CCDN1, promoter and other genes involved in the cell-cycle. It promotes the formation of a chromatin loop in the CYCLIN D1 gene, and is preferentially expressed in a range of different human tumors.
Statistics
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PSSM-Id: 318715
View PSSM: pfam16566
Aligned: 31 rows
Threshold Bit Score: 152.367
Threshold Setting Gi: 209572795
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NAD_B          6 EELIKALQDLE-NA-ASGDATVRQKIASLPQEVQDVSLLEK-I---TDKEAAERLSKTVDEACLLLAEYNGRLAAELEDR 79
gi 209572795  166 QDVLVSLKRLQ-NP-PSTERDIRIQLSKYPDNISCPEKLQS-V---QNSEEAKALLTQNEEALPMLEDYVKRLKEETKER 239
gi 195998241  171 EELVRCLSDLE-QS-ASGDVVIRKKISELPKEFEDVGSVDS-I---QSKAEAEKLLKKVDEAVLLLADYNGRLTAELEDR 244
gi 1009343381 211 EDVISLLKKLE-DP-PSADAETRQLIASFPETIANPALLKP-I---RNESQAMELLKKIKEAEPVVKEYCKRLAAEMEDR 284
gi 844861818  230 SELIQLLETLQ-SA-ASADAATRREIAQFPPEVSDPNKAME-ImksSSEQEQQALIELISKCSSRLDVYNQLLEEETTKR 306
gi 340372223  186 llklmtsvdgE-KS-AIQDMALRQRIANFPSHLYDVDILSK-L---KSKEACQELLEEVKEPLEILSQYTKKMEDELKER 259
gi 954267141  238 TDVIDFLTKLK-NS-PSSDAFTRQSIAALPADLCNLQKIRS-I---TDSQELDKHLTIAEQAQHMVNEYVKRLSEEMEMR 311
gi 313226892  254 EDFIAQIIKVAtDP-PSADASRRNRIANLPPEVQEPGCLEA-L---RDNNKLEHLVNLIDFSYMDLDEYTKALDDEVSDR 328
gi 674592469  231 iELVQKLDALQ-NSaPSANVATRQKISEFPVEVSNPEEAAKmI---AQRMDKETLIQSIRTALSQLEVYNASLDEEMTQR 306
gi 541039102  206 EELLAILKKLE-DP-PSADADTRQLIASFPESIANPSLLKP-I---KREAEARALKEKIDEAEPVVMEYCERLVDEMNER 279
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
4NAD_B         80 RQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLS-LLPNvtg-glAPLPSAGDLF 151
gi 209572795  240 ESLETNLNMLIQNVRMSIEHHEKLCRDVKRKEDRIKADLLEVEKTFESLPDLTaEMPN------APLPTLEALF 307
gi 195998241  245 AQGLRKLDELITIHQAELEKTEKELEKCKTKLATTAKVKKELKIHIESLPDLS-LLPDvtg-glAPLPAANDLF 316
gi 1009343381 285 RFLQQLLPEYFGFLKASAVRNDEMLRSVREKVEKLEQEKTSVKEHFDSLPDLA-DLPss---alPPLPSLGELF 354
gi 844861818  307 NQLALQLRAFHSHLNERILQAKIEVDDLKSKLDHGHSLKSELNKHILNLPDLH-LLPDmtnfglDPLPTVGDLF 379
gi 340372223  260 QEIEQLLESFLWLHQCLLYKARERQKDYRQKMEQCQHVKVTLNSHIASLPDLA--APNsd--slAPLPSIGDLF 329
gi 954267141  312 SKMMNTLETLTEILRKRADEGAEKYARLMNLAVEIDSKCNALQQHYQSLPVIS-TE-Nivl-eeRQMPTVNDLi 382
gi 313226892  329 KQLNLYNKTLRERIQTLQDGSRELLQETHRKVDRVKKNIADLDRKIQSLPDLT-TLSQi----sTPLPKLADLF 397
gi 674592469  307 QNLSLSLRAYKQALRESCQNIQSAIQCIREKRALIGSLQNSLDSHICNLPD---DQKPeae-flEPLPSVGDLF 376
gi 541039102  280 RNVQRLMSDYYEFLKADSLRNEELLNSVKEKFSKLDSEKAAVKKHLESLPDLN-DIPad---alTPLPSLSELF 349
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