Conserved Protein Domain Family
CLP1_P

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pfam16575: CLP1_P 
mRNA cleavage and polyadenylation factor CLP1 P-loop
CLP1_P is the P-loop carrying domain of Clp1 mRNA cleavage and polyadenylation factor, Clp1, proteins in eukaryotes. Clp1 is essential for 3'-end processing of mRNAs. This region carries the P-loop suggesting it is the region that binds adenine or guanine nucleotide.
Statistics
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PSSM-Id: 318723
View PSSM: pfam16575
Aligned: 88 rows
Threshold Bit Score: 102.699
Threshold Setting Gi: 503792140
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75032660  130 GENQWEREAVSRALLNLAVRHGSpyGICYVDLDVAMPMVGCPGTVSAAFVEEPV---TAPEDFGVMMPLTFFH-GTASVT 205
gi 74537469   36 GDVDTGKTTLIVYLANELISRGF--KVAIVDADVGQKGILPPATISLALADMKF---SS---LSELKPLIHYFvGSITPS 107
gi 41018423   39 GGVDSGKTTLATFLANELLNLGF--KVAIVDSDVGQKSILPPATISLAFPETNF---NN---LYEIKPYKSYFvGSTAP- 109
gi 74502529   34 GGVDSGKSTLITFLGNELLSLGF--KVAVVDSDVGQKGVLPPGTISLAIPEGPF---ESMSELEGVA--HYFV-GTTAPS 105
gi 74580717   44 GPQDSGKTTLVTFIANELVERGL--KVGIVDADVGQSDVGPPAVVSLGIVEDTV---HD--LSEVEMRHGYFV-GSITPS 115
gi 504026824  33 GARDTGKSTFAIWLANTLTTRGE--RVGLLDADMGQPSYGIPGAMSLAL---PA---SGHAG-SLHASTSWFV-GDTSPA 102
gi 501266903  90 GKVDSGKSSSILYLANKLLLNGT--RVSIIDSDIGQSDLGPPGVISSSNLRDPV---YQMKLLDPEF--MYFI-GDKSPR 161
gi 119524233  96 GGVDSGKTSFVTFLANRLSQAGE--RVGIVDADLGQKSIGPPATIGLGVVASPLvslGEAEFV-----DGFFV-GSVTPS 167
gi 490171022  34 GGVDSGKTTLTVFLANELLSQGF--RVAIVDSDVGQKGILPPALISLGFPDSIF---TT---MEEIKPVKHYFvGTITPN 105
gi 503833936  31 GPVNAGKTTLARWLAAQ-VNEHY--RTLFLDADPGQSLVGPPTTLALSRV--PI---DPDRWLR----L-RFV-GHISPE 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75032660  206 SATRkRYLDLCVCAAQAATSLGFANSKFEAGGFLIHSLSPS-TEI-QHDVL-SD-V-LSIFAVTHVVVTGAdRE-LEKFL 279
gi 74537469  108 Q--------FFGEMIVGTMRLSEIGKK-FADYVLIDTTGMI-YGS-GVELK-RL-K-IEAVKPDLILALEK-KE-ELNPI 171
gi 41018423  110 -------IQFFGEMITGTKLLCDYA-EDKADIIIVDTTGLI-SGS-GADLK-RM-K-IEMIKPDIIIALEKrNE-LKSIL 175
gi 74502529  106 Q--------FIGEMAVGVKRMVEI-ARNVADVVLIDTTGFV-TGV-GAEMK-RL-K-AELVKPDIIAVIHS-GE-LSGLV 169
gi 74580717  116 GHLL-QTTVGTRRMVDLAL---AE----GTDVVLIDTSGMV-HGG-PARALkLH-K-VDAIRPSHVAFLDR-DG-QVSHI 181
gi 504026824 103 RHMLpVL-AGVQCLRDHAMER-------GATRLVIDTTGLV-SRQgGGEAL-KRwK-AELLRPGSIVALRKaEE-LEGVL 170
gi 501266903 162 GHLLqFL-VGTWEAFRDVKEKT----------ILINTTGFV-DGA-AARTL-KK-LkIELLQPDVIIFIER-SEgELRHL 225
gi 119524233 168 GLLH-RHVVGVRLMVEVAET------RMGVRRVVVDTTGWV-SEQ-GGRELkLF-K-AMALEPDVVVVVSRgDE-CLHIV 235
gi 490171022 106 --------QFFGEMVTGVKLLVNEAMKRRADIVIIDTTGLV-HGS-GVELK-RM-K-IEMVKPDLVLALQR-KD-ELEDI 170
gi 503833936  97 GHL----LQMLSGLVR----LVEAARWHRAQRLVIDLPGHMaNDA-GRELF-FQ-M-LDVIRPDYVVALQR-ED-ELEPV 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 75032660  280 YNAVL-GRTVHFVRLPKLAGVqspSSAGAEQRRRAQLERYFF 320
gi 74537469  172 VSGFE-DKTIKLKVSENARSY---SRSERRQIRQEKWRKYFE 209
gi 41018423  176 K-PFE--NKIRVFYLKVYENAksfSREERKEIRAEKWKEYFK 214
gi 74502529  170 KALEP---YGGVIELAVSETVkryPLEERRNLRAEKWRNYFR 208
gi 74580717  182 KRMVKsLKYIKVHDLAVPDAVkdvERKDRIRRRERVLREFFE 223
gi 504026824 171 GPWRT-DSRFHLVELDVAEQVrprSPEQRAMRRRDQWRRVFt 211
gi 501266903 226 IRSVP-I-GAKAVNVRSPVRDlpkDKGYRSLCRKALYKKYLE 265
gi 119524233 236 -NTLG--RLFEVVQVEAPKAVrlrGRIDRREYRKVMYRKFFE 274
gi 490171022 171 LRPFE--NKTRVIRLAISENAklhTREERRQIRKEKWKKYFE 210
gi 503833936 163 LRCFRrGRRPRIVRLPVAEAVqerDRWVRSDYRRERFRRYFA 204
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