2L42,3PC6


Conserved Protein Domain Family
BRCT_2

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pfam16589: BRCT_2 
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BRCT domain, a BRCA1 C-terminus domain
This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.
Statistics
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PSSM-Id: 318734
View PSSM: pfam16589
Aligned: 91 rows
Threshold Bit Score: 50.7698
Threshold Setting Gi: 444321829
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2L42_A         13 SNMKFYLnrdadaHDSlnDIDQLARLIRANGGEVLDSkprESKENVFIVSPY-NH----------------TN------- 68
gi 597775707   22 EPMRFFI------RPGp-TKMQLQPLIQDCGGVVCRT---QEPN-AILLAEP-GEvsaa---------tdgAG------- 73
gi 281206246   15 KSIVFYLi----gVPIg-EQNKIKTLLKKCGGSIALQ---VNKSVHYLITTT-EEveka---------sykIKgatklcd 76
gi 221139732   20 TPMSFYV------PPGp-LKRQLYPLITHGGGEMCRM---QQPGALLLSAPG-SAq----------------G------- 65
gi 156393798   26 SPILFYI------TPGp-LKKRLKTLIEVRGGIVSSK---ITPGVDTILLQE-SSkdkp--------------------- 73
gi 196005709   16 KPMKFYI------KPCp-TKGKVRPLIESCGGQVIVH---PTDGVI--------Rlaep---------dtlTP------- 61
gi 484856218   54 KGLKFYI-----------KDNEIGSLIEMYGGKLVKN---IKKCDFYLEKKYfNKdkee---------gdgAY------- 103
gi 754413960   26 EPIQFFIp-----INEd-DRDNLEKLIIDHGGEVIND---PGAGYYISKHHd-------------------PL------- 70
gi 300701066   49 TGISFYa-----------SNTTFKKKIEDYGGVLTDD---ITKCTYVLTHKT-NKvnin--------tyelYK------- 98
gi 330791481   23 RGINFYIm----gLGFs-ETTQLKALIKSYGGDVAFQ---INKNVKYLLISK-EEleknmnstkiqsaikiPT------- 86
                          90       100
                  ....*....|....*....|....*...
2L42_A         69 ---LPTVTPTYIKACCQSNSLLNMENYL 93
gi 597775707   74 ---QFYISTQYIRDCVTQNQQLDMKTYR 98
gi 281206246   77 egeLRLVSTQYITDCVEANRLLSDDRYQ 104
gi 221139732   66 ---AQYVSTAYIMDCVRIDKLLDVDDYR 90
gi 156393798   74 -lldGYTSSEYIKDCIHKNELLNIKPYQ 100
gi 196005709   62 ---LGYVSASFIFDSVANNALQDIESYM 86
gi 484856218  104 ---IPVIHIRFIYDSIYKLEMMPINKYV 128
gi 754413960   71 ---RDAVDPKFIYESTEQKSLLKVDNYk 95
gi 300701066   99 ---SVVLDEVYIFECIYRLKKLNVENYi 123
gi 330791481   87 ---IEILSIEFISHCIEKRYLplesvke 111
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