Conserved Protein Domain Family
PTN13_u3

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pfam16599: PTN13_u3 
Unstructured linker region on PTN13 protein between PDZ
This natively unstructured region lies between the first two PDZ domains on long eukaryotic tyrosine-protein phosphatase non-receptor type 13 proteins. The function is not known. However, since each of the PDZ domains binds with a different protein it is likely to be a linker region allowing flexibility between the PDZs.
Statistics
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PSSM-Id: 318742
View PSSM: pfam16599
Aligned: 16 rows
Threshold Bit Score: 225.023
Threshold Setting Gi: 47219895
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47219895   1235 QPKERLYR----EaASGYEAIQAKASVDTFDSDQDGEISVDDLSDEHGRIESPSPPPHSSDAAassLSPVHQQSS--VPD 1308
gi 395542177  1183 KPKEKISK----A-PSTPTYLSNRIKNYVPRPSSIKDNDLESSLEDHHQTQCYQRRISLCSSA---LSGGQKEGSlsSQD 1254
gi 1033405028 1190 QPKEGLTK----V-SPS---LLNGMKGYLKRPSLIPDHETESSSEEHNQLLSHQKSTSGNVSG---LCSSKWDGSlsSQD 1258
gi 847094360  1174 QPKEKFIK----D-SQSTH-----SSSQSQRAFPPQDIEADSSSEEQSRLRGHQRLKSGSSSG---MSVGKREGSlsSQD 1240
gi 823459605  1181 QPKDKLSK----A-SSNTAHISNGARGYLRRPSSVQDNEAESSSEEHSRCRGHQRPASRSLSG---LSGGKQDGSvsSQD 1252
gi 971393906   702 QPKEKPSK----A-SCSTSHLTNGTRTYVRRPSSVQDNEAESSSEEPSRSRAHQRAVTGSVSA---LSGGRRDGSvsSQD 773
gi 1046859254 1168 QPKEKPTK----V-PSTPVHFANGMKNYTKKPSSMQDSAMD-PSEDQPWPRGPLRHVPESPFG---LSSGLREGSlsSQD 1238
gi 688604545  1144 QPKERLFP----DsPSGAHHYN--------PATQIQELDMDSSSEDH--TRSPSPPFTASKTS---PPQSIRQGSisSQD 1206
gi 908468732  1190 QPKERLYKespgG--YSPYQ--HRSSFKSLNSAQRQELDVDTSSEEHAGTRSPSPPQQSAGIQssnSSPAQQHTAlsSQD 1265
gi 768919383  1195 QPKERLYR----E-TASGDAIQAKPTINAFYSDQDGEVSVDDLSEEHVRTESPSPPPHGSHAIaaaFSPVRQPAN--SQD 1267
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47219895   1309 PKTNA----VKTKPN-GVQQCl--DRILATAATSSTGQPHKPAAHRSLDPVPPALPPKTRRAKFSEAPKAPEHPDRGDSD 1381
gi 395542177  1255 SRTESan-lSQSHLN-GFLVN---HLGAPAQQEFQHSSPSSLAVSKPAEKKQTSNEHNQSKAKKLGISETVDYSDRGDSD 1329
gi 1033405028 1259 SRTESas-lSQSQTNgGFLGN---HINVQAQQEFQHCNNSQLSLLKCKERNGSSLEVNLIKAKKNGIQETTEYSDRGDSD 1334
gi 847094360  1241 SRTESas-lSNSQIK-SPTNS---AKEHIAKQSAHTAKYPSLDSTRAGDRKRTQGDSSKGKGRRTGLAEPID-SDRGDSD 1314
gi 823459605  1253 SWTESas-lSQSQAA-SFFGK---RASGRAQQDAQHCSESQAGASKAIEKRRSSSDSTRAKMKRPGVVEPVEYSDRGDSD 1327
gi 971393906   774 SRTESas-lSQSQTA-SCFGR---RASGRSQQDPQKYPDSQSGVLKTNEKRRSSSDSTRAKMKRSGVVESVEYSDRGDSD 848
gi 1046859254 1239 SRTESas-lSQSHVN-GFFTS---HLGDRGWQEPQHSSPSPPVTSKITEK--TFSDSYRSPARRQGTCDVTELPGCADSD 1311
gi 688604545  1207 SKTESag-lQQTHLN-GFHKNipmEGPVAAQALPADIKPSI-------EAMPPALPPKTRKAKAADVPKELEYSDRGDSD 1277
gi 908468732  1266 SKTSImaktNQAPAS-GVQQY---LERSAAKTTPTAQHPNVGP-----DPTPPALPPKTRKSKVLEAPKVSEHSDRGDSD 1336
gi 768919383  1268 SKTNV----VKTKPN-GVQQCl--DRILATAATSTTSQHHTGS-----DPIPPALPPKTRKPKFSEAPKVTDHSDRGDSD 1335
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 47219895   1382 MDEENHCNSQGKvk-------keIIMERFSGNAPGvnslqPGDLF 1419
gi 395542177  1330 MDEATYSSSQDHqtkke--pssmSTSTKMNLKKNSsappkPGDIF 1372
gi 1033405028 1335 MDEATYSGSQEQaaaaakkggvntnvrhgglyvkaiipkgaaead 1379
gi 847094360  1315 MDEETYSSSQERrttkk-estfeRAAQKVNCTKLSptplkPGDAF 1358
gi 823459605  1328 MDEATYSGSQEQqpakk-dssssNTANKVNSKKVSttllkPGDIF 1371
gi 971393906   849 MDEATYSSSQEQqvaqk-essstNTADKMNSKKVSaellkPGDIF 892
gi 1046859254 1312 IDDPTYSSSQDRqapkqepssplKASDKMSFAAFPgpspePGDAF 1356
gi 688604545  1278 MDEDTYSNSQDKlktkk-gvspiTITETLSASSPDvnslhPGDLF 1321
gi 908468732  1337 MDEETYSSSQEKqkv-----kkeNIMENLNGNASGvnslhPGELY 1376
gi 768919383  1336 LDEDAYYSSQEKvk-------keIIMESFSGNAPGvnslqPGDLF 1373
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