Conserved Protein Domain Family
Caskin1-CID

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pfam16600: Caskin1-CID 
Caskin1 CASK-interaction domain
The Caskin1 protein interacts with the CASK protein via this region.CASK and Caskin1 are synaptic scaffolding proteins. The binding motif on human Caskin1 is EEIWVLRK. A similar motif is found on protein MINT1 and protein TIAM1, both shown to be able to bind to CASK though the motif. MINT1 and TIAM1 are not part of this family. This region is predicted to be natively unstructured.
Statistics
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PSSM-Id: 318743
View PSSM: pfam16600
Aligned: 8 rows
Threshold Bit Score: 45.3449
Threshold Setting Gi: 973183531
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551502587  374 EEIWVLRKPVAGGDRSsvGSSGSV------------------------------TSVRSSGSGQSATNAAHI-------- 415
gi 620971132   27 EDIWVLRKPFAGGDRSslGSTGSV------------------------------ASARSSGSGQSGGSGVHT-------- 68
gi 395835771  373 EEIWVLRKPFAGGDRSssSSVSSV------------------------------AGGRGSGG--------HA-------- 406
gi 821469427  291 EEIWVLRKPFTGADRS--SSLGGV------------------------------ASGRSGGSGS------HA-------- 324
gi 831554298  461 EDIWVLRKPVAGGERS--GSVCSL------------------------------GSVRSTSSLQGSG---NThvlttpap 505
gi 768942864  368 EDIWVLRKPLAGGERS-----GSvgsigslrsssslqnsgnthvlttpapsphpAN--TPGGVNTHGLNAPG-------- 432
gi 835982033  113 EDIWVLRKPLAGGERS-----GSVgslgsvrsssslqgsgnthvlttpapsphpAP--TPG-VNTHGLNAPG-------- 176
gi 973183531  339 ssiveviskrAGGDRSsvGSSGSV------------------------------ASARSSGSGQSAGGSVHA-------- 380
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 551502587  416 -------------------LHAQAEGVKLLATVLSQ 432
gi 620971132   69 -------------------LHPGSEGVKLLATVLSQ 85
gi 395835771  407 -------------------LHAGSEGVKLLATVLSQ 423
gi 821469427  325 -------------------LHAGSEGVKLLATVLSQ 341
gi 831554298  506 sphpaptpglnthglnapgLHAQSEGVKLLATVLSQ 541
gi 768942864  433 -------------------LHAQAEGVKLLATVLSQ 449
gi 835982033  177 -------------------LHAQAEGVKLLATVLSQ 193
gi 973183531  381 -------------------LHAQAEGVKLLATVLSQ 397
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