Conserved Protein Domain Family
CYLD_phos_site

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pfam16607: CYLD_phos_site 
Phosphorylation region of CYLD, unstructured
CYLD_phos_site is a natively unstructured region on a subset of tumor-suppressor and de-ubiquitinating enzyme CYLD proteins in eukaryotes. It lies between the second pair of CAP_GLY domains, pfam01302, on these proteins. This region of CYLD, being unstructured, carries a number of serine residues which, in response to cellular stimuli, become phosphorylated. This transient phosphorylation-state induces ubiquitination of TRAF2, a ubiquitin ligase that catalyzes both self-ubiquitination and the ubiquitination of specific target molecules involved in signal transduction.
Statistics
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PSSM-Id: 318748
View PSSM: pfam16607
Aligned: 6 rows
Threshold Bit Score: 223.262
Threshold Setting Gi: 348500058
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043424994  61 PESITQDRRPLKLAYMSRC-GSEKNLSSHSKPKVTGSTSESGSRTRSEFFYTLNGSSVETQHQSKSKNTWYMDEArerss 139
gi 348500058  303 PEYSMQDQRLQKHSFAPRGpASDKSSSSQSKPKSKGLGHQCGSRSKSEFYYTLNGSSLDPPAQPKSKSTWYIDEV----- 377
gi 193785836   82 PESVTQERRPPKLAFMSRG-VGDKGSSSHNKPKATGSTSDPGNRNRSELFYTLNGSSVDSQPQSKSKNTWYIDEV----- 155
gi 940775552  304 PDSVTEERRPPKLAFASRG-TGDKGSSSHNKPKVTGSTSDPGSRNRSELFYTLNGSSVDSQLPPKSKNTWYIDEV----- 377
gi 733906373   37 PETVSQDRRPPKLAYTARG-GGDKGVFNHSKPKATGSTSEPGNRNRSEVFYTLNGSSVDSQPQAKTKPPWYIDEV----- 110
gi 1033367784 100 SEPVSQERRPPKLAFTSRG-GCDKG-FNHNKPKg--AISDPGIRNRSEFFYTLNGSSIDSQPQTKSKNTWYIDEV----- 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043424994 140 rgssgvqensrcetVEDSAKSLTDSShAAFGHCSPPLQPSASSSSPGENRFHSLPFSLSKMSSTNGTMGHTPLSLSVQSV 219
gi 348500058  378 --------------GEDPAKSLTDTP-PDFNQSSPPSRAPPSASLSSDNKFHSLPFSLNRKPGPIDSMSHGPLSLSVQSV 442
gi 193785836  156 --------------AEDPAKSLTEIS-TDFDRSSPPLQPPPVNSLTTENRFHSLPFSLTKMPNTNGSIGHSPLSLSAQSV 220
gi 940775552  378 --------------AEDSAKSLTELP-PELGQASPPLQPPTMNSLSSENRFHSLPFSLTKMPNANGTIGHSPLSLSVQSV 442
gi 733906373  111 --------------AEDPAKSLTDSS-PGFGHSSPPLQPALTNSVTTENRFHSLPFSLTKASSTNGAIGHSLLSSSVQSV 175
gi 1033367784 171 --------------AEDSAKSLNDTS-PGFGHSSPPLQTPPTNTLSAENRFHSLPFSLTKMSSSNNAIGHSPLSLSVQSV 235
                         170
                  ....*....|....*...
gi 1043424994 220 IGELNNVSLQDIPPRFTH 237
gi 348500058  443 MGEQSESPSSAAPPSPRP 460
gi 193785836  221 MEELNTAPVQESPPLAMP 238
gi 940775552  443 MGELNTTSVPDSPPVAAS 460
gi 733906373  176 IGDVNTTANQESPSTGGP 193
gi 1033367784 236 IGEGNVGSTQESPPSMVA 253
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