Conserved Protein Domain Family
SH3-WW_linker

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pfam16618: SH3-WW_linker 
Linker region between SH3 and WW domains on ARHGAP12
SH3-WW_linker is a natively unstructured region on Rho-GTPase activating factor 12 proteins that lies between the SH3 and the WW domains. it is found in higher eukaryotes, and the function is not known.
Statistics
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PSSM-Id: 318759
View PSSM: pfam16618
Aligned: 12 rows
Threshold Bit Score: 212.842
Threshold Setting Gi: 597794086
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768961674  67 EV-RKALMpppkplphppaasgnPPP---H-NASAV------------KGK-PTSLDLGLQNQPAENLH------RQESS 122
gi 765147064  67 EV-RKALM---------------PPPkpiPyHHGGAsktp----gssyWVK-PAHLDLGLKDQPAEGIS------RRESK 119
gi 556973423  73 elpRKALM---------------PPVkqaG-LHASG------------SSK-QK----SSLQKSTENESkv---pELSSF 116
gi 565321531  69 EItRKALM---------------PPIrslVgLPNNS----------------LKLAHG--LQRSTENVNks---pEHSTS 112
gi 637309559  69 EVtRKALM---------------PPIkqlSvLPNST----------------LKLMHG--LQRSTENVNks---pELSSF 112
gi 971381784  69 EIpRKALM---------------PPVkqaGmLPNNA----------------LKLTHG--LQRSTENVNks---pELSSF 112
gi 426364379  71 EVtRKALM---------------PPVkqvAgLPNNS----------------TKIMQSLHLQRSTENVNkl---pELSSF 116
gi 620962549  69 EVtRKALM---------------PPIk----LPNNP----------------KKLVQDMPLQRSSENVNks--spELSSF 111
gi 348525568  70 EV-RRALM---------------PPQkp------------------alRAK-PAVLDI--CRASNENLNrp--qpEMSSF 110
gi 597794086  73 EV-RRALM---------------PPPk--------------------pRAKpPSILHISQCPSINENPQqhrappDMISF 116
gi 688579668  73 EV-RRALM---------------PPPk--------------------pRAKpPNVLEITHCRSSNENLNqra-ptEKSTF 115
gi 941766363  67 EV-RKALM---------------PPPkpiS-HSLTAsgnsnprsaaalWVK-PTTLDLG--NQVTDALH------RHESK 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768961674 123 YR-RSPSAQ-TAATDRFSPPIHRRDSNnhRTPGSPTDHDRALAE------GPHPDTRGKSSTLPRARARSPE-----LVR 189
gi 765147064 120 TR-RSPSAQ-TASSGHFTPPSQRRNSNhyQPPLSPTDHEPALEA------GSQRPQQGSSITLPRSRARSPD-----LVR 186
gi 556973423 117 GK-PSPAQT----------AGHARETN--QNLSQNNNPSQS-GQgldsiqNNVK----SHSPKTSSKNRITT-----GGR 173
gi 565321531 113 GK-SYLVQA--------------QDVN--QNLGSNSSPGQNTGLsielalNNGKF-NDLQFVKVSNQNMNLS-----GSH 169
gi 637309559 113 GK-SSPVQM----------LGPIRDAN--QNLGPNSSPGQNTGLsldlaqNNGKF-SEFQFPKVSIQNKSFS-----VSH 173
gi 971381784 113 GK-SSPVQV----------SCLVRDAN--QNLGPNNSPGQTLGLsldltqNNGKLNNELQSPKVSNQFRTIS-----MGH 174
gi 426364379 117 GKpSSSVQG----------TGLIRDAN--QNFGPSYNPGQTVNLsldlthNNGKFNNDSHSPKVSSQNRTRS-----FGH 179
gi 620962549 112 GK-SSSALA----------TSLVRDAN--QNFGPNSS---SQTLsldlthNNGKFGSDSQSPKVPSQHRIHS-----MGQ 170
gi 348525568 111 GR-PSPSSTpSPSSDRVTPPALPKDAN--QNVGSPH-HCKLVAElvllhnNNNHHHHPNNSTLPRMRADSPTpklgnNHK 186
gi 597794086 117 GR-PPPSTTpSPLPGQQTPPLLLRDTN--QNAGMRD----VLAEltllnnNNHHDHHHGNSLLSRIRPESPPkepgcRGK 189
gi 688579668 116 GR-PPPSTTpSPLPGQQTPPLLLRDSN--HNPGMKS----VVAEltllnnNNHHNFHHANPTLPQGRAESPPrdqgcQGK 188
gi 941766363 121 AR-RSPSAQ-TASSSHFSPPIHRRNSNhhHTPSTPTEQERCLAEilvqggFPQ---KGSSSTLPRTRARSPD-----SLK 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768961674 190 APl----DVDSTq-----G-CDSAGE--ERRTNDSESGDEMSSSSTEQLQTVXsSGQGRSESPVYTNLQELKITQSTLPP 257
gi 765147064 187 DPl----EGDGT------H-CDSAGE--DRGTNDSESGDELSGSSTEHLQMGS-SGQVGSDSSIYTNLQDLKISQANLPL 252
gi 556973423 174 FPcsefmEVEKTsfsqeqS-CDSAGEgsEKHLHDSESGDDLSSSSTEHMQPTTpTGQGRSDSPIYANLQELKlslsslpp 252
gi 565321531 170 FHcsecmETEKTsfl-qeQpCDSVGEgpEKIHQDSESGDDLSSSSTEQVQPVTpPSQGRPDSPVYANLQELKISQSAPPP 248
gi 637309559 174 FPcsdcmEIEKTsfl-qeLsCDSAGEssEKLHQDSESGDELSSSSTEQTQPTTpPSQGRPDSPVYANLQELKISQSALPP 252
gi 971381784 175 FPcpeflEIEKTsfl-heQsCDSAGEgsEKIHQDSESGDELSSSSTEQAQPTTpPSQGRPDSPVYANLQELKISQSALPP 253
gi 426364379 180 FPgpeflDVEKTsfs-qeQsCDSAGEgsERIHQDSESGDELSSSSTEQIRATTpPNQGRPDSPVYANLQELKISQSALPP 258
gi 620962549 171 FPgpefmDVEKTsfs-heQfCDSAGEgsERILQDSESGDELSSSSTEQIRPTTpPNQGRPDSPVYANLQELKISQAALPP 249
gi 348525568 187 SP-----DGSKTs-----PlSELPGEgmNKLRNDSESGDELSSSSTEHMQTTSpTGQGRSDSPVYTNLQELKISQSSLPP 256
gi 597794086 190 PPgglplDTDGS----------SPGEgsEKLRNDSESGDELSSSSTEHMQTVSpTGPGRSDSPVYTNLQELKISQSSLPP 259
gi 688579668 189 LTgglsvDTDGS---------VSPGDgvEKMRNDSESGDELSSSSTEHIQSVSlSGQGRPESPVYTNLQELKICQSSVPP 259
gi 941766363 191 VP------PDVTq-----H-CDSAGE--ERRTNDSESGDELSSSSTEHLQTGStSGQGVSESPVYTNLQELKISKKSQPP 256

                 ....*...
gi 768961674 258 APAGSPLH 265
gi 765147064 253 QPSGSPLH 260
gi 556973423 253 apasppiq 260
gi 565321531 249 VPISPAVQ 256
gi 637309559 253 IPTTLPIQ 260
gi 971381784 254 LPTSAPVQ 261
gi 426364379 259 LPGSPAIQ 266
gi 620962549 250 LPGSPAIQ 257
gi 348525568 257 VPSGSPIH 264
gi 597794086 260 IPSSSPLH 267
gi 688579668 260 VPSTSPLH 267
gi 941766363 257 LPSGSPLH 264
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