Conserved Protein Domain Family
NEXCaM_BD

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pfam16644: NEXCaM_BD 
Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
NEXCaM_BD is a coiled-coil domain found as part of the regulatory, C-terminal region of the 12-14 TM sodium/proton exchangers (NHEs)2 of the solute carrier 9 (SLC9) family in all animal kingdoms. The C- lobe of CaM binds the first alpha-helix of the NHE, or NEXCaM_BD region, and the N-lobe of CaM binds the second helix of NEXCaM_BD.
Statistics
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PSSM-Id: 318785
View PSSM: pfam16644
Aligned: 19 rows
Threshold Bit Score: 132.872
Threshold Setting Gi: 765146315
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565318746 463 VSTVSMQNINp----kTLPIE-RI---LPal--skDKEEEIRKILRNNLQKTRQRLRSY-NRHTLVADPYEEAWNQMLLR 531
gi 930233576 442 PSSVSLSDYH------EGKIK-PL---SP------TEMENMREILTKNLYQIRHRTMSY-NRHSLAADASEKQAKEILIR 504
gi 512821311 565 PSLSSLSTYE------KQKVK-PL---SP------TEVNDMRDMLTKNLYQIRQRTLSY-NRHNLAGGTSEKQAKEILIR 627
gi 637329328 563 PSLASFSELQ------EEEKRiPS---YP------ALTDDIRDILTKNLYQIRQRTPSY-NRYSLAEDANEKQAKEILIR 626
gi 612024512 596 PSPVSIQNIH------PKTTD-RI---MPkl--skDKEEEIRNILRNNLQKTRQRLKSY-NRHTLVADPYEEAWNQMLLR 662
gi 542234497 583 PSTVSMQNIQprp-ptKPAAE-RA---IPql--skTKEEEIRKILRTNLQRTRQRLRSY-NRHTLVADPYEDGLSDLFLK 654
gi 765155421 454 PSIISLQEEK------KNSTK-PKkkfLA------ADLKNMHDILSKNMYKIRERTVSYtSKHAL---PNDNQRREILIR 517
gi 551493193 570 PSLVSLQGEK------KESTT-------PkktfmaEDLKNMHDLLSKNMYKIRQRTVAFtSKHALP---NDNQPREILIR 633
gi 542241018 569 PSIVSLYEEK------KSSSK-------PqkkflaADLKNMHDILSKNMYKIRERTVAYrGKHALP---NDNHTREILIR 632
gi 768920539 585 PSTVSMQNIQpkkppeakpaE-RA---LPql--pkGREEEIRKILRTNLQRTRQRLRSY-NRHTLVADPYEDGISDFLLK 657
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 565318746 532 RQKARQLEQKVegreGGIWGRWEKGPCEMNNYLTVPAHKIDSPTMSRAR 580
gi 930233576 505 RRHSLRESLRK----TNSLSRERPAAANTKRFLSLPKNTKLPEKLRVRN 549
gi 512821311 628 RRHSMRESLKK-----SSLNSRRAATVHQARYLSLPGHTKLFEGPTGKK 671
gi 637329328 627 RRHSLRESIRK----SNSLS--RPPASKAPRYLSLPKNTKLAEKVRKRN 669
gi 612024512 663 RQRALQMEQKI------------------NTFLTVPPQTPGSPTLNRAR 693
gi 542234497 655 KQKMFQIEKKL---------------KEMNTYLTVPAPPPDSPTMCRAR 688
gi 765155421 518 RHSSIRRSLRP----GSFQ--TRQIVPKSQKYFSLPPGESLNSRFPPTR 560
gi 551493193 634 RHANIRRSLRH----GSFQS----TIPRSQKYFSLPTGQNLGSKYSSVR 674
gi 542241018 633 RHVSIRRSLRP----GSFQS--SSYVPRTHKYFSLPAGKSLESTFPAAR 675
gi 768920539 658 KQKMIELEKKI---------------KGMKNYLTVPAAPPDSPTLSRAR 691
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