Conserved Protein Domain Family
FOXO_KIX_bdg

?
pfam16675: FOXO_KIX_bdg 
KIX-binding domain of forkhead box O, CR2
FOXO_KIX_bd is the first part of the region of transcription factor forkhead box O family proteins that binds to the CREB-binding proteins via the KIX domain. Coactivator CBP/p300 is recruited by FOXO3 via the binding of this domain as well as the simultaneous binding of the more C-terminal TAD domain.
Statistics
?
PSSM-Id: 318810
View PSSM: pfam16675
Aligned: 20 rows
Threshold Bit Score: 65.1219
Threshold Setting Gi: 573875412
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82181417  402 KYSYAQTGmNPVS-Q-MPMQTVPENK-SGYR-AVGQYPvpaGLLKELLTSDS---PPHNDI----LTPVDSAVSQA-N-S 468
gi 960979016 584 GTIYSQPAmSLMR-R-LPMQTIQENKqATFS-PVSSYRn--aSLQDLLSSIS---YAHKES----MVPGDLPLPQA-S-P 649
gi 655842834 434 sTVFGPSSlNSLR-Q-SPMQTIQENKpATFS-SMSHYGs--QTLQDLLTSDS---LSHSDVm---MTQSDPLMSQA-S-T 500
gi 301620062 328 GSIYSQPAmGMMR-R-LPMQTIQENKqAVYP-PGSTYRn--SSIQDLLSAMS---YGHKDS----LGQSDPGLT---N-V 391
gi 597784464 412 nsIFGPSTaG-LR-Q-TPMQTIQENKqTSFS-SISHFGn--tTLQELLNLESlgtHNHSDVm---MTQSDPLISQT-S-A 480
gi 637358455 264 GTIYSQPAmSLMR-R-LPMQTIQENKqASFA-PMHSYRn--SSLQDLLSSVS---YAHK--------ESDSHMPQA-S-S 325
gi 542246143 380 aPMYGQPSmGMLR-HhTPMETIQENKpVSFQrPVRGYSe-nNALQSLLTGGPr--YCNKDTvlsqGREPHTLMTQGtN-G 454
gi 410911280 377 GPRYTQSSmGMLQhH-TPMETIQENKpVNFQhPIRGYSe-nNALQSLLTGGPp--YCSKDPg--lGQEPHTLLTQG-StS 449
gi 47221266  337 sPLFSPPSiTSLR-Q-SPMQTIQENKqTTFS-CVSHFGd-hQSLQDLLSLDS---HGHSNVm---LTQSDPLMSQA-S-T 404
gi 573875412 427 NSIFGTPSlTGLR-Q-SPMQTIQENKqATFS-CISHFGn--QTLQDLLSSDS---HSHSDVm---MTQSDPLMSQA-S-T 493
                         90
                 ....*....|..
gi 82181417  469 R-VLAQNSlmAP 479
gi 960979016 650 M-VPARGHrhNP 660
gi 655842834 501 A-VSAQNSrrhv 511
gi 301620062 392 L-GPQRSHrqNi 402
gi 597784464 481 A-VTSQNSrlRN 491
gi 637358455 326 MgPPPRSHrpNv 337
gi 542246143 455 I-HSQHNHnqNR 465
gi 410911280 450 V-HSPQGH--NQ 458
gi 47221266  405 A-VALQNS--RR 413
gi 573875412 494 S-VSSQSS--RR 502
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap