Conserved Protein Domain Family
FOXO-TAD

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pfam16676: FOXO-TAD 
Transactivation domain of FOXO protein family
TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.
Statistics
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PSSM-Id: 318811
View PSSM: pfam16676
Aligned: 24 rows
Threshold Bit Score: 51.9013
Threshold Setting Gi: 241997566
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 408407626  569 RLPSDLD-DM--LIDQLdvECDVERVLHDTLMD-G-DALDFNFDP 608
gi 573887326  574 RLPADLDlDI--FHGSL--DCDVESILLNDFMD-S-EEMDFNFDC 612
gi 961005353  369 RLPIDLDiDM--YMENL--ECDMDYIINSELMD-G-EGLDFNFEP 407
gi 542246143  661 RMAADLEmEN--VPNSL--DCDVDSILLNDFMD-T-ENMDFNFDG 699
gi 1002572610 466 KLPNDLDvDM--YMEDL--QCDVDYIISTDLMD-G-EGLDFNFEP 504
gi 432882831  562 RMSAHVEmEN--ASHSL--DCDVDSILLSDFMD-T-QNMDFNFDS 600
gi 1029201558 641 RLQSELEmDV--HQSSL--DCDVESILLNDFMD-StEGMDFNFDG 680
gi 431914398  466 KMPQDLDlDM--YLENL--ECDMDNII-SDLMNgG-EGLDFNFEP 504
gi 241997566  606 PLPHDLDlDLdaVQG-L--HCDVDQVIQHELNV-D-GNLDFNFDS 645
gi 1005962254 552 PLPNDLDlNMdsLQGGL--ECDVDQVIRHELSV-E-GNLDFNFES 592
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