4DX8


Conserved Protein Domain Family
NUDIX_5

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pfam16705: NUDIX_5 
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NUDIX, or N-terminal NPxY motif-rich, region of KRIT
NUDIX_5 is found in higher eukaryotes at the N-terminus of KRIT1 or Krev interaction trapped proteins. NUDIX_5 carries three NPxY-like motifs, and it is found to bind the integrin cytoplasmic-associated protein 1 ICAP1. In the absence of KRIT1 ICAP1 binds via its C-terminal PH/PTB fold domain to the integrin beta-1 cytoplasmic tail. Binding of KRIT1 to ICAP1 via NUDIX_5 out-competes the binding of ICAP1 to integrin cytoplasmic tails such that ICAP1 is sequestered in the nucleus. Integrin activation is thus prevented.
Statistics
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PSSM-Id: 318834
View PSSM: pfam16705
Aligned: 8 rows
Threshold Bit Score: 242.727
Threshold Setting Gi: 762103952
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DX8_H        35 AKSYEILLHEVPIE--GQ-KKKRKKVLLETKLQGNSEITQG-ILDYVVETTKPISPANQGIRGKRVVLMKKFPLD----- 105
gi 126341562  30 AKSYEILLLEVPIE--GQ-KKKRKKVLLETKLQGSGEITQS-ILDYVVETTKPISPANQGIKGKRVVLMKKFPLD----- 100
gi 189230230  30 AKLYEILMIEVPVE--GQ-KKKRKKVLLETKLQGEKDTAQE-ILDYVLESTKLVSPSNQGVKGKRVVRMKKFTLD----- 100
gi 432952121  30 AKAYEILLREVPAE--GK-EKKRKKVLLATKIP-SGDKSKS-ILDYVDETMRPVS-GPQGSAGKRVVHMKTVPAE----- 98
gi 260819636  36 AKWYEIILLEDRL---GD-PQRTVKGLLHMRIRGGEDPNRQ-VLEYVYDATKKSSSKMQGLRGKRAVQIARFAEDeiagr 110
gi 762103952  27 PKLYNILLLDHRTTslGE-KGKPTKYLPTFPLTNLQEEAGDeVLANLYQLTGG---DHVGIKGERALQIQWSSDK----- 97
gi 597763725  29 AKAYEILLIEVPLE--GK-EKKRKKVLLGTKIQADSDKTKS-ILEYVDETTKPIS-NNQGIIGKRVVHMKKFPLD----- 98
gi 198426281  25 TKDVELFIQEAPGF--GKnDSDERKRLPSVKPRLSYHASKQaIIDHVFQVTKSASPSNTGIKAKRVIHAKDLKLQ----- 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DX8_H       106 GEKMGREASLFIVPSVVKDNTKY-----TYTPGCP-IFYCLQDIMRVCSESSTHFATLTARMLIALDKWLDERHAQSHFI 179
gi 126341562 101 GEKMGREASLFIVPSVVKDNTKY-----SYSPGCP-VFYCLQDIMRVCSESSTHFATLTARMLIALDKWLDERHAQSHFI 174
gi 189230230 101 GERTGREATLFLVPTAVKENAKN-----SYNPGSP-VFYCFQDIMRVCSESSTHFSTVTARMLIALDKWLDEQHAQSHAI 174
gi 432952121  99 GGAEA--ASLFVVPVGVKDSSKP-----VQSPGSP-SFYCLQDIMRVCSDTSPHLCPTTSRMLLALDKWLAEQHAVPHAI 170
gi 260819636 111 DTRSNKKAFLYVVPVATKDQLSM-----PTDPSQP-SFCCLQDILRVCAEGHGHFPTLTSRMLRTLDHWLKEQHSVPHAV 184
gi 762103952  98 YRESLTRFALFCVPVNKGDKLNRmf--aEKSPDYP-GFFSLDYVIDTLNNDTVAYPPPTRTFVSQLESWLREKHAMPGAI 174
gi 597763725  99 GENEGKEASLFIVPINVKDNSKP-----VYHPGSP-SFYCLQDIMRVCSETSAHFSSITSKMLLGLDKWLAEQHSVPHAI 172
gi 198426281  98 VNGTPENAILYVVPTLIRGPTTPypfqsSSEPNAPcGFHTLHQVTHEVNGQGDKYNEVVKPLVDALERWMKRQMSRPTSL 177
                        170       180
                 ....*....|....*....|....
4DX8_H       180 PALFRPSPLERIKTNVINPAYATE 203
gi 126341562 175 PALFRPSPLERIKTNVINPAYATE 198
gi 189230230 175 SALFRPSPLERIKTNITNPAYATE 198
gi 432952121 171 PALFRPAPVERVKTNVSNPAYGGd 194
gi 260819636 185 EALFRPSALERIKMNVLNPAYSHC 208
gi 762103952 175 NILFSRRADYRVKLSVNNPAFLPS 198
gi 597763725 173 PALFRPAPIERVKTNVSNPAYTTE 196
gi 198426281 178 QALFRPTALDRIHENITNPAYAAE 201
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