3QML


Conserved Protein Domain Family
SIL1

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pfam16782: SIL1 
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Nucleotide exchange factor SIL1
This family consists of fungal SIL1 nucleotide-exchange factor proteins.It interacts with Hsp70 (heat-shock protein of 70 kDa) Bip.
Statistics
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PSSM-Id: 318894
View PSSM: pfam16782
Aligned: 27 rows
Threshold Bit Score: 245.668
Threshold Setting Gi: 54039618
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QML_C        17 DYEFSSDFKEMRNIidsnPt-----LSSQDI---ARLEDSFDRIMEFAHDYKHGYKIITHE--FAL-----L-ANL---- 76
gi 74679926  134 LSNFDAACSEIESF----Kp------hESDV---ERLHLALDTLEELSHDIEFGVKLTSDK--A-------IfQSLvnia 191
gi 218511787 140 LNDFQSSVDEVQHY----Re-------GGDA---NRLSTALDTLIDLSHDIEFGVKLTQDS--S-------VfRSLvdvs 196
gi 255727735 151 LNDFDSASLEVEGY----Kp-----N-ASDM---DRLNTALDTLEELSHDIEFGEKLTTDKniFQS-----L-LNI---- 207
gi 150864922 135 LTSFDSAVAEIISF-------------SGDN---SRLSQALDTLIDLSHDIEFGVKLTASRdiFDS-----L-LEI---- 188
gi 598065247 132 LNNFDAAMEEAGQF----D-------VGKDV---ERFKLALDTLEDLSHDIEFGVRITRDG--PTT-------KNL---- 184
gi 149238508 177 LTNFDSALNEVEQY----DahlqtqTENNNK---ERFELALDTIQDYVHDIELGVKLTSSK--DSTv----L-RKL---- 238
gi 575512423 115 iNSFDSALDEVQSA----An-----GAGSD-----SLDQALDVLIDLSHDIEFGTKLASDGsaFSN-----L-NAI---- 170
gi 354548467 152 LTDFTSAVEKVEEY----Dq-----SKLDDVtekERLIKALDTINDLSHDIELGEQVTSNT--VLF-----N-KLV---- 210
gi 260950923 194 LSDYASSVEELLHF----Gk-------NADV---SRLEKALDTLIDLSHDIDFGERLTRDP--KVFsslldA-AQL---- 252
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QML_C        77 -S-LNENL--PLT-LRELSTRVITSCLRNNPPVVEFIN-E------S-----F-P-N-FKSKIMAALSNLndsnHRSSNI 136
gi 74679926  192 nG-ASDP-----K-ITEKVYRVMGSSLRNNPEAISNIL-T------N-----FdK-S-YVDNLFEQL-A------NENDV 243
gi 218511787 197 kS-VQDE-----D-LQEKVYRIMGSSLRNNPDAVNHVL-K------N-----QdA-T-FVECLFDKLDT------DASDV 249
gi 255727735 208 -A--DTAN--DAK-VEEKAYRIMGSSLRNNPEAINNLL-S------N-----F-DrD-FVTNLFSQLS-------KKDDV 260
gi 150864922 189 -G-QSHK---DDE-ITEKVYRIMGASLRNNPDSVTNLLrN------S-----D-G-S-FVAALFSNLSTQ-------KDV 241
gi 598065247 185 -I-KVATAyqDTD-VTDQIYRIIGASLRNNPEAIRNLL-D------D-----V-D-DvYIRDLFKQL-------HDSKDV 240
gi 149238508 239 -IdLAESG--DGE-LKSKVYNIIASSLRNNPEAVQNII-D------GrsgidY-T-A-FTKSLLGQLE-------LASDL 297
gi 575512423 171 -A-AKSSP--P---VQEKVYRIIGSSLRNNPEAIATFV-D------K-----DtK-E-LIGSWIKQLDT-------SDNL 222
gi 354548467 211 -D-LASTN--KDElIEEKIYNIITASLRNNPGAITNLL-NgkvsgfN-----V-A-N-FINSLLDDIS-------QSPDT 270
gi 260950923 253 -T-SSES-----Q-IPEKSFRIMGSSLRNNPAAVTNVF-E------K-----Q-D-DnFMVTLFATLESP-----ETSDV 305
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QML_C       137 LIKRYLSILNELPVTSedlp----------iystVVLQNVYErnNKDKQLQIKVLELISKILKADMYe-NDdtnlilfKr 205
gi 74679926  244 LQKRILGIIQALVQNShfvrqyfs---fdhssglNDLIAIFP--KLGPNSKSRASNILEDLQLFPvt--nD-------Rr 309
gi 218511787 250 IKKRILGIIHALTQNShfnakyfn--snnansavDSLISVFP--SLESQSQTRLMNILEDLKLLGGAnsnE-------Kr 318
gi 255727735 261 LQKRILGIIQALSQNGhftreyfs---fdhssglDNLIEIFP--NLGVESQTRASNILEDLQLFPVT--ND-------Rr 326
gi 150864922 242 IQKRILGIIQGLAQNShfayeyfs---hnknhgiSNLISVYP--QLGPDSRERCVNILEDLNLLSRDd-FD-------Rr 308
gi 598065247 241 IQKRVLGIIQALAQDSsfakqyft---fdhsyglDDIVDIFP--SLGPESRIRAANILEDLQLHDTTe-TK-------R- 306
gi 149238508 298 VQKRILGIVQALTQNVqfvesfftf-aqghnyglNTLVENFT--KLGPQAKTRAANILQDLDLVGKS--ND-------Rr 365
gi 575512423 223 VKKRVLGIFHQLVTNArfkyqyf----ngdfdllSKFIDIYP--KLNKSTKTRLLNILEDLKLVDEPs-SE-------Sd 288
gi 354548467 271 IQKRKIGIIQALAQDPsvaqqyfs---yehpnglNQLIKVYP--TLSLDAKIRVVHLLEDLNLWQNn--KE-------Kr 336
gi 260950923 306 VRKRIAGVIHALASDMafayqffnvedaskslgfSRLLRIFP--KADHETQERIAMLFEDLNLLPSSp-DK-------Rd 375
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QML_C       206 naENWSSNLQEWANEFQEMVQ-----N---KS----IDELHTRTFFDTLYNLKKIFKSDITINKGFLNWLAQQCKARQSN 273
gi 74679926  310 slED-Q----DPESQVSKFIQnsfvgN---KL----DEK-NFKSYFDQLVNLHQS-NKSLRPSGDFLNWLAEEVESR-KE 374
gi 218511787 319 aiEESA----DPKSQYSHFLQhsladS---GV----ASEDQFKLYFNKLSEVHSQ-DKSLKPSKAFMEWLSKEAELRSKG 386
gi 255727735 327 slED-----QDPESRVSKFIQ-----N---SFvgnkLDQDNFKQYFNQLAKLHQD-NKDLKPTNEFIEWLAKEAELRKEN 392
gi 150864922 309 avEEFN----NADLQISRFLQeslssN---EI----TSPIQFRTYFDNLVTLH-ERNKELKPTSDFLKWLATEVETR-KS 375
gi 598065247 307 -------EEQVPEQQFSSFIQkslieN---KV----IAD-QMKTYFTKLVELHKETP-SLQPSKDFISWLAQEVELRKEN 370
gi 149238508 366 slEDD-----DPSSNVSNFIQhalveN---KV----STQSEFEKYFDNLVTIHQQ-DETLKPTREFLNWLAREVEVR-KE 431
gi 575512423 289 ------------dSRVSNYIQakflkS---DF----KTEDQFKLYYQTLVEIHQA-DKSLQGSKAFVTWLDEESGKRQQG 348
gi 354548467 337 sdEDEEETETDPDSNLSQFIQqslarN---KF----GNENDANAYFSHLAELHKS-DKSLKPSSDFLQWLSKEVELRKDR 408
gi 260950923 376 ------EDSPKPQERVSEMLQ-----TlvpAS----QSEEQLQNMFKSLVELHR--NHDLRPSKQFLQWLSKETEMRKNT 438
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
3QML_C       274 lDNGLQERDTEQDSFDKKLIDSRHLIFGNPMAHRiKnfrD 313
gi 74679926  375 nKKRD-DYSQEDKDFDEYMLRARHEVFGNPMGLR-KaiaD 412
gi 218511787 387 nKERDSSYTEEDRQFDQDLLRARHVVFGNPMGLR-KalaD 425
gi 255727735 393 kKRD--DYSQDDKNFDEFMLTARHEIFGNPMGLR-KaiaD 429
gi 150864922 376 yKKR-EDYPQQEKDYDEKMLHARHVVFGNPLGLR-KaiaD 413
gi 598065247 371 tKRD--DYSQHEKDFDREMLIARHEVFGNPMGLR-KafaD 407
gi 149238508 432 kKKRD-DVSLEELKFDEEMLHARHEVFGNPMGLR-KaiaD 469
gi 575512423 349 lKERDGLYSNADKQFDKDMLETRHTVFGNPNAMR-KhfdD 387
gi 354548467 409 kKRN--DVSQQDLDFDRFMLEARHEIFGNPMGLR-KataD 445
gi 260950923 439 kNV----RDKTDADFDTFMLEARHLVFGNPNALR-Kadef 473
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