4ACO


Conserved Protein Domain Family
NDC10_II

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pfam16787: NDC10_II 
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Centromere DNA-binding protein complex CBF3 subunit, domain 2
NDC10_II is a the second of five domains on the Kluyveromyces lactis Ndc10 protein. Each subunit of the Ndc10 dimer binds a separate fragment of DNA, suggesting that Ndc10 stabilizes a DNA loop at the centromere.
Statistics
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PSSM-Id: 318897
View PSSM: pfam16787
Aligned: 16 rows
Threshold Bit Score: 320.839
Threshold Setting Gi: 365990515
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4ACO_A       186 LKVSLNLWNPETNHLSEKFFKTCSEK--------------------------------------------LRFLVDFQLR 221
gi 74687555  206 RQAGMNAFPSPRTKATNSILNALRRVrneqsilrcddkgddlfydgi--attenmkklflhylhrdsvegLRDLAAQAVG 283
gi 121922846 169 KALGMNTYPSPREDNAREYIKSLQRRdaeqqkanyadkgrdtlldgyseedlkriagelwgrtaqsaechLRTLVDLLLG 248
gi 121927458  96 KARGMNVHPSPREDNVREYLKTLQQRdaqqdkdnyadkgrdalldgyteeefervcyelwargsaspeyhLRTLVDLLLG 175
gi 367013734 136 VKVSLNLWNSHTESLSEKFFKTSLEK--------------------------------------------LRFLVDFHFR 171
gi 156838649 174 LKVSINLWNPQTLNLSDKIFKTGLEK--------------------------------------------SRFLVDFHFT 209
gi 255717711 139 HLVSVNMWTPHSNRLSEKYFKGGLER--------------------------------------------LRFLVDFHVQ 174
gi 367001334 167 LRVSMNMWNPQTINLNEKVFKTTSEK--------------------------------------------LKFLIDFHFT 202
gi 254586527 138 HIISANLWNPHS-QLPEKYFRNCFEQ--------------------------------------------LRFLVDFQWR 172
gi 403214019 138 VTVSLNMWNPEANSTN---FKSSMER--------------------------------------------LRFLVDFQFA 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4ACO_A       222 SYLNLSFEERSKIRFGSLKLGkrdrdai-----iyhkvtHSAEKKDTPGHHQLLALLPQDCPFICPQTTLAAYLYLRFYG 296
gi 74687555  284 IHGLLRADDQLRITLSSMSLRlfedegpt--pcrgvvfaIREGKTTHDGQIQYSTLLRNKDVTRCPVSFLVLYLFARFHF 361
gi 121922846 249 HYMLTRGGDRRALEISDLFTFefagegpt--rcmpliitTRAGKQNQHGRLETASALRSRDPLICVLGAIAFYLLFRWDL 326
gi 121927458 176 HYMLARGGDRRAAELSDLLTFeftgegpt--rcmpliltTRAGKQNQHGQLETAGALRNRRPLICMLGGLAFYLLYRWDL 253
gi 367013734 172 VYTNLSYEQRSKIKLSELHGEvgvlamdq--kvwsslqvYMPNSTRQVKSHMPLSIRSQELPFLCPLTSLASYLYLRFYG 249
gi 156838649 210 NYLHLNYSKRSIIKLFQLNGNkek------------nciTLDQYDETSRTHSPLLLLPQSCPFLCPITSLATYLYLRFYG 277
gi 255717711 175 QYWHLPFADRARLKLGDLRFAadpgm--------lhvvrQGQHGADAPETVQQLALLPQRVPWICPLVSLAAYLYLRFYG 246
gi 367001334 203 NYLNLSYSERAELKLSDLTTNnek-------------niIEINKPNDPSQMNPMVLLPQDCPFLCPLTSLAASLFLRFYG 269
gi 254586527 173 LYTKMSYMQRSRIRIAELVGHadgggisveldtwsqlgeYVNGVEPQLRSRQPVIVVSHANPLVCPLVSLASYFFLRFHD 252
gi 403214019 171 SYTKLTFQERSRLKMSSLQIRgqtlrdte---iwydtydDTVDDGNGTSLHRPVSLLPQDCPFLCPWTTLAAYLFFRFYG 247
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4ACO_A       297 IPSVskg--dgFPNLNADeng---------------sllQDIPILR--GKSLT---TYpreETFSNYYTTVFRYCHLPYK 354
gi 74687555  362 SEEPfinsdvsFPSLKNRqd------------------wYHIPLFVsrQSNAVtrlKY---DALNKSVRKALQSCNIHCR 420
gi 121922846 327 TNEP-------FPEFENRaq------------------wYDIRLLKstDASPTsefAY---NSQRDWVIKAFAYAGIQSI 378
gi 121927458 254 TDEL-------LPDFSRRaa------------------wYDIRLLKsyGSDRTaalSY---NSQRDWVVKAFGYAGVTSQ 305
gi 367013734 250 ISSVtkg--dgFPDLLASdqdd--------------lywKDLPLIR--GKSLT---DYpreETMSNYYSAVFRYCHLPYK 308
gi 156838649 278 IRNVykg--dgFPDLSNTikqskmdyssvtklsanlihwLDLPLIR--GKSPL---DYpkdETMSNYYSIVFRYCHLPYK 350
gi 255717711 247 APKAykg--dgFPDLLGAde------------------wAFLPMVR--GKSLD---KYpreETMTNYYAHVFRHCHLPYK 301
gi 367001334 270 IKNVykg--dgFPDVSKIskpsqsdydkeaklsanvvhwQDLPLIR--GKSPL---DYpkdVTMSSYYNMIFRYCHLPYK 342
gi 254586527 253 gg--------gFPELRDAng-----------------swREMPIVR--GKSPG---DYpreETLGNYYAAVFRYCRLNYK 302
gi 403214019 248 IKSGfrg--dgFPDLNNDdl------------------vRSLPLIK--GKFAA---EYpreNTLGLYYSSVLKYCSLPYR 302
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4ACO_A       355 RREYFN-KCN---LVYPTWDEDTFRTFFNEENhgnwleqPEAFAFPDKIPFDFKKIMnfkspytsYSTNA-------KKD 423
gi 74687555  421 ASTHTSrKWGaqlAEDGGAPEEDIMRQGRWCTk------VMETVYLSKFPLKALRAL--------AGFPK-------KKg 479
gi 121922846 379 KKTHVGrSSGaktAELKGISEAQIQRAGRWNQe------QMVGCYLNSLSRKFMRTM--------AGHPA-------QMg 437
gi 121927458 306 KKTHVGrSLGaktAELKGVSEDQIRRAGRWNQe------QMVGCYLNALPRKFMRTM--------AGHPS-------QMg 364
gi 367013734 309 RREYFN-KSt---LEYPTWSHQSFTDFFDKYPs------AKRTAFQHEVPFDYDRIMnlrslnetKEN----------EA 368
gi 156838649 351 RREYFQ-KTRv---EFPTWTDEEFNEFDNILKe------SMSTAYKYKVPYDFAKILnlkspfipYDNVDnsl------- 413
gi 255717711 302 RREYFY-NKSvdyCQYPEIRRTELDQLQEIAPa------QQRELFPHLIPLDFLRHMnhfpvyepPSENHya-------- 366
gi 367001334 343 RREYFQ-Dr---qEVFPKWNKQEFEEESHQYEs------IAKQFFKYNVPHDFITILnhkspynsFESLSknf------- 405
gi 254586527 303 RREWFG-QSK---LQYPSWRPEEYEFFKRYQPe-------LQEAFPMNVPRDFVECFnlgvgrgtVDDK----------- 360
gi 403214019 303 KKNYFE-GMR---PNFPQLDYREFELLNERMPd-------------DVVPFDFKRILnakspylsDKSTAsnfncnwKNE 365
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4ACO_A       424 -------PFPPPKDLLVQIFPEIDEYKRHD---YEGLSQ-NSRDFLDLMEVLRERFLSNLPWIYKFFPNHDIFQDPIFGN 492
gi 74687555  480 syy-lprDMEVPQELIESVFPWVDAAEAELfdpDRFQGDkAGRAFIKLMDWFRSVLIQDAPFIRQLEPDLFVWKHPVFST 558
gi 121922846 438 cfeirraRIPPPGSLLPLIWPDLNRWAGKFgpgPGQVNDlAAAGFTTLLFYLREVILQDSALLMRQFPDCAVWSHPVFQH 517
gi 121927458 365 cfeirraGIAPPEALLSMIWPGLDSWKDRFgprSDQVNDlAAMGLTNLLFYLREVALQDSVLLMQQFPNSPVWNHPVFQH 444
gi 367013734 369 -------LSALPESLLVQIFPEVEQYKRE----VDQLSP-EAKAFIQTMENLRKRFLYNLPWIHEIFPQHDLFKDPIFQN 436
gi 156838649 414 -----tneSMLPASLLDQLFPEIDQYKRH----SNILSK-EAKNFLNLMETLRNALLKNLPWIFHFFPHHDIFKDSLFSN 483
gi 255717711 367 ------dLANVPKSLLVQVFPEIEEYKR-S---SIPLGE-QAQHFIDALQLLRSALVSALPLFYHFFPEHDLFKDPMFQN 435
gi 367001334 406 -----tneEQLPSHLLVQLFPEIGYFK-NS---ADNLNK-EALEFIKVIEALRNTLLKNLPYLYHFFPHHDLFNDTILTS 475
gi 254586527 361 -------IVGGRRDLLVQLFPEIESYKRH-----GGLDQ-DAQRFVDLIEVLRIHLLRALPVLYRLFPDHDLFKTDTLSK 427
gi 403214019 366 -------SIGPPRTILTQVFPEIEKFKKD----KTLLSE-ESQAFLDLLELLRLQLVSNLPLIYKVFPSHELFRHDIFNN 433

                 ...
4ACO_A       493 SDF 495
gi 74687555  559 PTF 561
gi 121922846 518 KDY 520
gi 121927458 445 EAY 447
gi 367013734 437 SDF 439
gi 156838649 484 SDF 486
gi 255717711 436 AEF 438
gi 367001334 476 PEF 478
gi 254586527 428 PDF 430
gi 403214019 434 SDF 436
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