Conserved Protein Domain Family
RXLR

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pfam16810: RXLR 
RXLR phytopathogen effector protein, Avirulence activity
RXLR is a family of phytopathogen avirulence or effector proteins. RXLR proteins are defined by a secretion signal peptide - not in this family - followed by a conserved N-terminal domain with the sequence motif RXLR (Arg-Xaa-Leu-Arg) consensus sequence. The RXLR part is required for translocation inside plant cells, although it appears to be dispensable for the biochemical activity of the effectors when expressed directly inside host cells. The effector activity resides in the C-terminal part of the family, which activate effector-triggered immunity in plants that carry a corresponding resistance (R) protein. The C-terminal region exhibits a fold appears to be able to evolve to outwit the host as the latter tries to acquire new immunity.
Statistics
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PSSM-Id: 318914
View PSSM: pfam16810
Aligned: 10 rows
Threshold Bit Score: 84.882
Threshold Setting Gi: 347360743
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301110981   1 MHLHCVLMVLVAILAASNGAVSATIVKEDSEHVKINRAhs------iqTLQTDTRRKRFLRTED---KF----------N 61
gi 301093375   1 MRMHSVLMMVVATLAIANGSVSAAGGSNLRKAKATSSIns------fnTVQTEAKNSRMLRNTD---VA----------T 61
gi 301123109   1 MRVSYVLLVAVATLLITCDVVSA--------QPSTLSLpa------sdGAMIEDTNNQPLRLLE---IT----------T 53
gi 301101407   1 MRLSSVVSVAIAIVCLTTSHFAQARISLPDLV----------------GGRDDAASMKRIR------------------T 46
gi 543200488   1 MRLAIMLSATAVAINFATCSAI------DQTKVLVYGTpa--------hyIHDSAGRRLLRKNE---EN----------E 53
gi 347360743   1 ------------------------V--------ESTATstdlirslgtAPSADQLNVQSLRS------------------ 30
gi 301087619   1 MRLYLILSASMVISYFVTCNAATSS---DQTKLSRMEPsllvh-slgaALNVDAVDRRFLR------------------E 58
gi 301110989   1 MRMHSVLMMVVATLAIVNGSVSAAGGSNLRKAKATSSIns------fnTVQTEAKNSRMLRNTDvatGEnghvyyypakK 74
gi 301110979   1 MQLRYILLLAAATLATASSTTSAASGTRDPKTPTVASNhh------ieKTVTAQADHEFMRSLL---------------E 59
gi 301101225   1 MTL-----VVLATVLLLSGTAVSNADRASVLNVDAVHSsni----------ltAEEKRFLRSHQttdDEg--------eN 57
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301110981  62 TDYyyDPAKR---DDHRS--------------AFIENKLEKSLTNPRKTTKLYEQWYKRGYTLKRVSSGLNQDENRelqr 124
gi 301093375  62 GENg-HVYYYpakKGERK--------------PFIEVRLKKALSNSKKVNRLYEDWYKSGFSTKKVAKELNQSENRelke 126
gi 301123109  54 ADD---GEERmaeARLMD--------------SEI---LEKIVNDHAYAKQVFRSWLQNGQTKEDIENRLKTLGll---t 110
gi 301101407  47 SKE--NEEERgalKTITNia----------nrVQVKTAANGLLADSGKAHGVYRKWAAKGYTLDDIRNFLKVTDPKmk-g 113
gi 543200488  54 E----TSEERapnFNLANlneemfnvaalterADAKKLAKQLMGNDKLADAAYMWWQHNRVTLDQIDTFLKLASRKtqga 129
gi 347360743  31 --K--TATTRaagHRLLRavetka----sdsksiDAKVLEDILHNRDYAEATFSSWLRNGQSRQDIEVRLTEQGll---s 99
gi 301087619  59 RKE--SMEERgyhlt---------------lkgeVKALAKKIIADFDTADDVYKKWNENGHSLNKIANLLKVSEKEkyvp 121
gi 301110989  75 GER--KPf--------------------------IEVRLKKALSNSKKVNRLYEDWYKSGFSTKKVAKELNQSENRelke 126
gi 301110979  60 DDD--NSATQgq--------------------tfMEHKLKKMLTNPKKAKQLYQHWHKKGYTAKQVASDLGQTENRaldq 117
gi 301101225  58 NEH--VGEERaggANLLA-----------------GLKLQKMGRDTSYRDKVFQRWKNYGKSVEDVSDHVPSSLTQaf-e 117
                        170
                 ....*....|....*
gi 301110981 125 vYQELAHG-YAAYIK 138
gi 301093375 127 tYKTLAIG-YTAFVK 140
gi 301123109 111 kYGNVVKQ-YAQYLt 124
gi 301101407 114 kYQQIVDD-YNRHLF 127
gi 543200488 130 kYNQIYNS-YMMHLG 143
gi 347360743 100 kYSSVIDQ-YDSYCL 113
gi 301087619 122 vYNG-----YLAYLN 131
gi 301110989 127 tYNNLAIG-YTAFVK 140
gi 301110979 118 tYKKIAKE-YAAFVK 131
gi 301101225 118 iYLRMRKNtGKVYTR 132
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