2KIC


Conserved Protein Domain Family
DIMCO_N

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pfam16844: DIMCO_N 
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Dinitrogenase iron-molybdenum cofactor, N-terminal
DIMCO_N is the N-terminal domain of the gamma (Y) subunit of nitrogenase. An alternative name is NafY_N, for nitrogenase accessory factor Y N-terminal. This region is negatively charged and appears to be necessary for recognising and interacting with the apo state of dinitrogenase. The full-length NafY protein facilitates the transfer of iron-molybdenum cofactor, or FeMo-co, into apodinitrogenase by binding to both. The C-terminal region, family Nitro_FeMo-Co, pfam02579, is the part that binds to the cofactor, and the N-terminus binds to apodinitrogenase. Nitrogenase is the bacterial enzyme responsible for nitrogen fixation by catalyzing the reduction of nitrogen gas (N2) to ammonium in an ATP-dependent manner. It has two components, dinitrogenase and dinitrogenase reductase.
Statistics
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PSSM-Id: 318942
View PSSM: pfam16844
Aligned: 24 rows
Threshold Bit Score: 71.5792
Threshold Setting Gi: 491366963
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KIC_A        10 SRETALRIALAARALPGTTVGQLLEILHQRIEGPLTEESLQGVSVTDLKIGLa------GSEEDVDMlDTPMSA-LKDAV 82
gi 644125448   7 DRECALRIALAKKVLPGIELPRLLEIIIERIGAPIKEEALASMTAEDLRQGLkrtrhpdIEQDECN-----SQS-LEMAV 80
gi 502027639  13 PAHLALRIALAARSLKGVDTAHLLRALIAAVGEPITEARLRKLRASRLRTRLle---tcGE--GVQS-TLTDRQ-LHSAL 85
gi 121588484  20 QPELALRIGLAARELPELDVSQLVRVLTALLGAPLTAEKLAGVTPRGLRda-------gGAHHLEAV-QQAPAArLEAAC 91
gi 506297199   7 DKEVALRIGLAVKELDAISTQEFLGLLIKIMGEPITPAKLDKLRAKKVKLLAges--ldT---------VSSET-FERAF 74
gi 753849019   7 SDDIALRVALAARALPETPPARLLKVLADAVGLPLSEQRLNGLTVRQLKTaa------dGELGEVDV-----PL-LKGAL 74
gi 557032014   7 SEDIALRIGLAARTLPDTDPARLLRVLADAVGLPPTAAKLDALTVKALKTaa------dAEFADID-----AGS-LKKAL 74
gi 504592799   7 SDDIALRIALAARTLPDTDPARLIRVLKDAVGLPPTAESLAGLKVKDLKQaa------dGEFADLD-----QAV-LKAAL 74
gi 502736089   7 TEDMALRIGLAARTLPDTDPARLLRVLAELVGLPPSAERLATVRVKDLKQag------dGEFAHLD-----QSE-LRAAL 74
gi 369938435  13 PAHLALRIALAARSLKGVDTAHLLRALIAAVGEPITEARLPKLRASRLRTRLlet-cgeGVQSTLT-----DRQ-LHSAL 85
                         90
                 ....*....|....*
2KIC_A        83 RILWGEAEVDSLPQP 97
gi 644125448  81 RYLSGEREVEPDLPA 95
gi 502027639  86 GLLKGRGVRMPEDPl 100
gi 121588484  92 RALHGEEAATDPVPE 106
gi 506297199  75 ALLKGRGIRQFLNPK 89
gi 753849019  75 AFLKGEAVGDSTPPP 89
gi 557032014  75 ALLKGQGIGTVEPlp 89
gi 504592799  75 AILKGDSGLDLTPPP 89
gi 502736089  75 AILQGEGVEQPDPPP 89
gi 369938435  86 GLLKGRGVRMPEDPl 100
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