2LQL


Conserved Protein Domain Family
CX9C

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pfam16860: CX9C 
Click on image for an interactive view with Cn3D
CHCH-CHCH-like Cx9C, IMS import disulfide relay-system,
CX9C is the first half of a twin Cx9C motif in eukaryotic proteins. The function of this motif is to import nuclear-encoded mitochondrial intermembrane-space-proteins into the IMS (intermembrane space), as these latter lack a mitochondrial targeting sequence. The Cx9C proteins have a disulfide-bonded alpha-hairpin conformation. Cx9C-containing proteins are thus putative substrates for the Mia40-dependent thiol-disulfide exchange mechanism that carries out an oxidative folding process resulting in the proteins being trapped in the IMS.
Statistics
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PSSM-Id: 318953
View PSSM: pfam16860
Aligned: 38 rows
Threshold Bit Score: 42.3022
Threshold Setting Gi: 514694001
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
2LQL_A        11 TARYCGRELEQYGQCVAaKP-ES--WQRDCHYLKMSIAQCTSSHP 52
gi 365761573  13 VVANCPQEFLQYHKCIR-DN-EE--NPAKCQDGRLTLSKCIKEKV 53
gi 673526964   8 VAAKCGKQLETFQRCIL-AN-QQ--NPSACEPYKVELSRCAASAV 48
gi 363753024  58 IMKECGDKMKNYEQCVR-DNmESrtINENCLDLLKEMRLCAEGQV 101
gi 363753024  12 VAKHCPKEFMLYHKCIS-TN-HE--DPSQCGFRERDLTKCIRSRV 52
gi 254577047  12 VARYCPREFMEYHKCVS-SN-RD--DLQQCAFRQKDLSSCIQNKV 52
gi 164658882   8 VGKQCQDQLAVFQRCIY-VH-RN--DPASCTQPQQELAKCASNAV 48
gi 588260853   8 ISQKCSEQLEKYQSCIL-SN-QQqdWNAICKPQRDELTKCADNSV 50
gi 575477258   8 VSKHCGLQVKLFGACLE-RNgGN--WESNCLKEKNQLTKCAEENV 49
gi 357138171  18 VVKPCMMEMTSFLNCLA-LN-KQ--SDDKCARQKELLVTCTQAQk 58
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