Conserved Protein Domain Family
HRG

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pfam16954: HRG 
Haem-transporter, endosomal/lysosomal, haem-responsive gene
HRG1 is a family of conserved, membrane-bound permeases that reside in distinct intracellular compartments and bind and transport haem in metazoa. These proteins carry four transmembrane domains, 4xTMs, modelled here in two pairs, the two N-terminal and the two more C-terminal.
Statistics
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PSSM-Id: 319027
View PSSM: pfam16954
Aligned: 41 rows
Threshold Bit Score: 27.2805
Threshold Setting Gi: 410920395
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82080857   72 LRFFLFIGILFSALSVVGFCTFLVLAITQHQ-------------SLT-----------------D-PRSYYLSCVWSFIS 120
gi 321474608  77 lRNIQLLAFLLTDISIAVFAWYLFYAAYYKI-------------PMV-----------------PvDNSAIVTSVWVFMT 126
gi 332206409   8 lGLRAAYSGISSVAGFSIFLVWTVV--YRQPgtaam----gglaGVL--------------------------ALWVLVT 55
gi 655829975   8 lgLRAAYAGVSSVAGFSIFLVWTVV--YRQPataam----gglaGVL--------------------------ALWVLVT 55
gi 410920395   6 IHISIAYASFGMLMGFSAFLTWNIA--YIQPwtaam----gglsGVL--------------------------ALWTLIT 53
gi 348508086   6 tYMRIAYASFGTIVGFSAFLVWNFV--YNQPwtgam----gglsGVL--------------------------ALWTLIT 53
gi 198424376  10 LHCRIAYSLFGIAIGVSVFVIWLTV--FDNRketyatvtygglsGVL--------------------------AAWNLIL 61
gi 260829235   8 LAFRISFAVLGTFVGLSAAVCWIQV--FKSYdtaaf----gvasGLT--------------------------AAVALTI 55
gi 393908167   7 mKVRLFWPVIGIISGIIAGLCFAIV--YRNWsatvm----afisSIV--------------------------AVNLLFI 54
gi 308491716  33 INVRIAYTICGIIIGLFWACVYIFAWKVNIQ-------------SVSlvimlflfqnwvalatcLvATSFAFETFFFYFS 99

                 ....*....
gi 82080857  121 LK------W 123
gi 321474608 127 AK------W 129
gi 332206409  56 HVmymqdyW 64
gi 655829975  56 HImykqdyW 64
gi 410920395  54 HVmylqdlW 62
gi 348508086  54 HImylqdyW 62
gi 198424376  62 HImhyqdlW 70
gi 260829235  56 hilyareqw 64
gi 393908167  55 H-------W 56
gi 308491716 100 IKkdtilkW 108
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