Conserved Protein Domain Family
SRP68

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pfam16969: SRP68 
RNA-binding signal recognition particle 68
SRP68 is a family that is part of the SRP or signal recognition particle complex. This complex, consisting of six proteins and a 7SL-RNA is necessary for guiding the emerging proteins designed for the membrane towards the translocation pore. SRP68 forms a stable heterodimer with SRP72, a protein with a TPR repeat. Specific RNA-binding of SRP68 is mediated by the N-terminal domain of approximately 200 residues of this family.
Statistics
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PSSM-Id: 319040
View PSSM: pfam16969
Aligned: 76 rows
Threshold Bit Score: 343.862
Threshold Setting Gi: 367001378
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121962466   37 LQDYKKYR----------Q----------------YCSKRIQRLRSQLRKQYGKK-NYVNKIVlnggeTEKQI-NDVRYL 88
gi 514690161   42 HGDFQRYR----------K----------------FCTRRMHRVRKNLKFTQGKR-KFVQTRV-----GLKQVqKAVNFL 89
gi 575484802   26 QQDYQRYR----------E----------------YCARRIRRVRKNTDMIQGKk-RYEKKPV-----TPTSL-VDPRSL 72
gi 552842624   38 HSDYQRYR----------QaaidarppgtitpatqYCSRRLRRVYKGVKFLHG-RgRYQKKKL-----EPEAI-KDVRHL 100
gi 303272313   40 HDDHGRYR----------Q----------------YCTRRLARVYKSLKFTHG-RgKYQKKTL-----DAAMV-KDERHL 86
gi 146183890   31 HSDFQRYR----------K----------------YCGHKVHKLRKLMKFSHEK--KYQKKQI-----HVERL-NDPKML 76
gi 159476318   47 HGDYMRYRaaegdlflrrK----------------HCASKLQSLYKVLKMQHGRT-KYVKRKL-----DVPNV-TDVRHL 103
gi 473987008   75 HGDYTRYR----------R----------------YCTARLRRLYKSLKFLHGRG-KYTRRNI-----TESTV-TDVRFL 121
gi 586662587   46 HGDYTRYR----------R----------------YCTARLRRLYKSLKFTHGRG-KYNRRSI-----TESTV-TEVRFL 92
gi 302829406  413 paeanACR----------K----------------HCVSRLQTLYKVLKMQHGRT-KYQKRKL-----DVHHI-TDVRHL 459
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121962466   89 QISLLKTERAWSYAMDLKAQfek-------dndSRIGFHMNRRFGKASRNSTQLYELCK-LVA-DQYTIIEAHAYSSWMA 159
gi 514690161   90 EIPVLSAERAWAYFREDKQLsk---------qeTRKLHHAGRRLRKAITWADEVVRLVSkSKAfDSLTALEAQAYADWLH 160
gi 575484802   73 QILLFEAERSWAYAMQLKADsq---------yePRKKHHSIKRLCRAVSSANQLHELCQlESI-DHQTSLETQAYALRLA 142
gi 552842624  101 HIPLVQAERAWAYAMDLKSQleq-------dmvPQKRQHLIRRLAKAARHAADLVALAa-QRC-DARTQLEAEAYSLWMA 171
gi 303272313   87 LIPLMTAERAWSYAMELKRDag---------nePRKRAHMLKRLKKATVHAAELVSLCNqVG--SARTALEAEAYSSYIF 155
gi 146183890   77 QVLLFKIENNWAYAMDLKQImqds-----kdgaARKQHHVNKKMAKALKWANLLNNICr-ERT-DERSYQESEAYLNFIK 149
gi 159476318  104 QVPLFSAERAWSQAMELKKEaevrgs--agaadPRKRQHLIRRLSKAVLWATELARFAA-ERA-DTRGALEAEAYCSWMA 179
gi 473987008  122 HVVFYMAERAWSHAMEKKTAgp----------nAPQRIYMLGRFRKAVKWAALFSQLCS-IKG-DSRTSLEAEAYASYMK 189
gi 586662587   93 HVVLYMAERAWSHAMEKKQVpdg--------pnARQRVYLLGRLRKAAKWAILFAQLCS-AKG-DSRTSLEAEAYASYMK 162
gi 302829406  460 HVPLFNAERAWAYAMELKKEaeargggaaggidPRKRHHLIGRLAKAVLWASELARFAA-ARS-DTQGALEAEAYCCWMG 537
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121962466  160 SSLSLTKQ-DFKKALEEINISKTIYEKLSEQG-DHSQKELYQKR-------IEetePIIRFCLYN----LKNEK-NTSNK 225
gi 514690161  161 ALTAFESK-QWKDAESLFSRAKQTYTQLLKLAaSDEEEKIYERK-------VQeldASARYCLYN----LEGTG-DIKSL 227
gi 575484802  143 AYVHFERQ-EWQSALDVFASSRSIYDKLAHVAvTASHATLCQAA-------MDeidPNIRYCAYN----LKFKG-NQTDD 209
gi 552842624  172 GSVLLEKEsDWEGALARFLRARQLFEELAKVG-SFEQQGVCKHF-------LDqvdPTVRYCQYQ----ISRKGgAAPSP 239
gi 303272313  156 GSYLTEQErDWDRALAKFMRARKAYEQLARVG-GPDQAEICRER-------LEelePSLRYCTYK----RGSGS-TGASD 222
gi 146183890  150 GIYHHERH-QWEDALESYIKSRSIYLSLISVS-DSLQSVFFKEK-------VEfleQSIRYCHQQnngfILDTI-DVIIS 219
gi 159476318  180 GQLMLEREsDWEAALAKFSRAKKLWQELAKACpDLEGQSLCLAQ-------VEemePNIRYCNYR----ISRAG-GAVPA 247
gi 473987008  190 GTLLFEQEkNIEAAMLNFKNTRTVYEELGKYG-GIENQLLCRQR-------IEevePMIGFCSRK----LGGSA-LQEHD 256
gi 586662587  163 GSLFLEREqNWDTALQDFKKARAIYEELSKYG-DVENQILCRER-------VEelePSVRYCLYK----MGKSS-LPASE 229
gi 302829406  538 GNLLLEREsDWELALAKFTRAKKLWQELAKACpNLEGQSLYLAQarrergrVEemePNIRYCNYR----ISRAG-GAVPA 612
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121962466  226 VSQNt-----------------LtIIEQSL-------E------------------ELKNQENKKKSStsstttttaTTT 263
gi 514690161  228 LELRsald-----------tdeMdLLSDQL-------D------------------SALTAKRQEDGNt--------IKE 263
gi 575484802  210 IESLlelrkt-------sggpgNdLLSAKI-------D------------------LLVTERMHVKARa--------IHT 249
gi 552842624  240 AELLelig-----------gsgTdQLQSKI-------A------------------S-----LAAEAQaek---aaaTSS 275
gi 303272313  223 APGSm-----------------DdADMAALkgeggvdE------------------EIFKAVLAEEDGrat----vtPTA 263
gi 146183890  220 KMGTk-----------------MdIEKTPT-------S------------------KVAQSEKKDQ-----------LIE 246
gi 159476318  248 DPAElmalgggg---dtgalpgLdLLQSKL-------A------------------ALAQEAQVAQAAa--------TSY 291
gi 473987008  257 LLDMeke------------gpaYdLFKAKI-------EdnrlkpesvesrntpdilAVLSETRSQQAAs--------MTE 309
gi 586662587  230 LLDMgkme-----------gpsLdLLQAKL-------E------------------AVMAEARSRQAAs--------MTE 265
gi 302829406  613 DPSAllsavsdvgarggelpggGdLLQSKL-------A------------------ALAQEAQMAQAAs--------TSY 659
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121962466  264 IEWKSKSIKV-DEKLDEKLKIFNEFKKENENklp------------kniNAS----------IdttSNISPIFNIYDKLV 320
gi 514690161  264 LEWLDRTVPLkSSRLRAQITAVHAKADDIKQ-------------------LP----------Sd--EDEKTMMAAYDALL 312
gi 575484802  250 MEWHGYSMDIhNEDLMAMIMEMQEISAKING------------------EVQgngivvdgrvDe--SQFAGIMAEYDKLL 309
gi 552842624  276 LSWAGETY--------------AELQSELDG------------------AMEv--------eGg--GEVDARVSLYDRMI 313
gi 303272313  264 MVWRGREIPVrNREARACIANAVSQLSKIES--------------------P----------Lt--MSAERGLAIYDKSF 311
gi 146183890  247 VDYLGSKYPIkNQKAIYSYRQVEDCQKRIHE-------------------LQ----------Rk--TSKTNTQEEQDSIL 295
gi 159476318  292 FEWMGARHPVrNERVKLALHQAGEFGTQADQaaaeqaaaatasasgaatAMD----------TgagDALDARLALYDKAI 361
gi 473987008  310 FNWLGRRFPItSAKTRVSILKAQQLERDLNG--------------------A----------AtepISADKKLAIFDKLF 359
gi 586662587  266 FHWLGHRFPItNGKTRVSILKAQELEKDLYG--------------------S----------AgdsLPAEKKLATYDKIF 315
gi 302829406  660 VSWMGVNHPVrHERVKLALHQAAEFGAQAEQ------------------VMD----------SgegDVLDSRLALYDKAI 711
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121962466  321 YNLINCETIVKNDLStlvrvnlKNKSVKSEIEEQST---RILLAYIMYHKMKYLYERNSILITMMQRVLDGEKVDESAI- 396
gi 514690161  313 MAFGDALATTDDLADee---lkAAGGLTSDAIKENLaqlQFVRAYLEFHRLQHTLDRNLAMISRCMRAYTGEDDG----- 384
gi 575484802  310 GLGWDAAKLSERDIKedlvavmKVKSSKSDMHSAML---KLIKEYVTYTRLEHTFDRDILLEQATSMRLKNLVHSSGSV- 385
gi 552842624  314 NAYGEARQAIKSVLAl------GQGGADSAQLRGEL---MALDRAVQGLVLERTIQRNLFLAGDAEARFARTQRRQLSGq 384
gi 303272313  312 LFYNDARQHLRDDLAsas-ssqGGGGSESTGRLAEI---KLADRALAVLLSEKTIERNKFLVASVTAKLTGEIKVEK--- 384
gi 146183890  296 AIYNEAFNNFDECIKvi----qKEKSDEKNSEAENLi-yTNILSFLNLNKQKFILDRNIILIKNAVQQFDKEDGVNNLEa 370
gi 159476318  362 NALAEAKSHVRNAVK-------GLAGPDAEAHFKEL---EALEVAVEGARLQRTVERAQAHLEHTRARFAAGLQRLALG- 430
gi 473987008  360 SAYHEARSCIRNDLA---------SAGSAENIRDEL---NGLDKAVSAVLGLRTIERNQLLVSIAKSKFAKHRDEK---- 423
gi 586662587  316 AAYHDARRCIRSDLV---------TAGNSEDVKDDL---NGLDKAVSAVLGQRTIERNELLVSIAKIKFNRNREDK---- 379
gi 302829406  712 NALAQAKSHVRNAVK-------GLAGPDAEAHFKEL---EALEVAVEGLRLQRTVERSEVHLAHTRTRFVAGLQRLAAG- 780
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121962466  397 --Kk---KVKKVTWNDLVRLSTHQVKVYTIMSE-----S---RD-----TDS----NKEIARDQDAQLILLKSIRLYYIA 454
gi 514690161  385 -----------SRPEDIVRLFDLAAQSLDEMLE-----V---EF-----AEE----DDAFVARADAYKPYFRAMRCFYIA 436
gi 575484802  386 --Ek----RPSQRREELIQLDITMLQVVNEMKE-----L---DI-----IET----DLALGHLVSSKGFFVVAQRLAHTA 442
gi 552842624  385 --RqrgeRERPARAEDVVRLYELLVANTSELNE-----LaahVG-----GAA----GEMLMDDCAAKQAHYQAARCLYLA 448
gi 303272313  385 -------GEKAAKPEDLVHLFNTLLQNYEELAEsgpevM---RG-----VEGaeglEEEIQLDCILNQTLLKAQRAAALA 449
gi 146183890  371 ltTkkafKLKLIRPTEIIKLCDNLLQVFKQIIE-----V---ER-----QNT----NLENYRKLDVLEFHFKAIRCYYVS 433
gi 159476318  431 --KkikdKERHARPEEVVRVLDLLGRHLEDLAD-----L---GArl--gGRA----GEALHEAAAARATAARAMRVYHVA 494
gi 473987008  424 -------NEKITKPEELVRLYDLLIQNTTDLTD-----L---VSsgrdkNEE----ENAFVHEYELKDLAFRAERCFYLA 484
gi 586662587  380 -------NEKVTKPEELVRLYDLLIQNTADLSD-----L---VSsgrdrRPE----EVEFTEEYVLKGMVFRAERCFYLA 440
gi 302829406  781 --KkikdKERHARPEEVVRVCDLLSRYLEDLAD-----L---GArm--gGRA----GEALHDVAA--------------- 829
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121962466  455 VCLAKS------------------LKFSETMAVLDRVLTNIQNVRKTNTKNQQ--------------ILNDTNELESNIK 502
gi 514690161  437 ESFRLL------------------GKLREALAMFDRASEVAAVARTKLQAQPAefa---------epLLAALDSVQVRMR 489
gi 575484802  443 DIYTAD------------------QKYAEALVLLNKAMEQVHLSRTSVVEFKRkiikhd--qqmavnMTKLLDVLSQSIC 502
gi 552842624  449 HSMLAA------------------EKYREAAGLFGRAADRCKQAASKYEDCSKpdvaa-----geqlEALAQQA-AAWGA 504
gi 303272313  450 KVHLGA------------------GSHVEAAVLYARAAEHAARVQDra------------------aAASEMNAVASKVQ 493
gi 146183890  434 CVYLAN------------------SKYIETLSLLKVAENIVTNSSKKFVDMRDnfv---------edYVEESDILMKKIK 486
gi 159476318  495 HALLAAapaagsdaaaaapsssgpSKALESYALFSRAQQRAAEAAESLKGLAGgdaaagvllkgreaLLAELAELGRQAA 574
gi 473987008  485 KSYSSV------------------SKRAEAYALFCYARSLADSALQELANSPHkvlksnsnaltlqaLIQDLEALSFNCR 546
gi 586662587  441 KSYSLA------------------GKRAESYALYCRARSLAENVLQKVQQSMnpd----------kgM-KELEFLIASCR 491
gi 302829406  830 ------------------------ARALEAWALLSRSQDRASAAADQLRGLPAgdpaaevllrgrdgLLEDLGELVKQAT 885
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121962466  503 KQRSQIHANS----------FIQqL-----S-ENqdlknqm-sslsigGITT----A-------SGK----SNDLISGLD 550
gi 514690161  490 AVRVGMQAGA----------FLQaSr---rQ-EDesaartd-eegavpDDDA----D-------RLA----DVPLSETIN 539
gi 575484802  503 NRSLITKAKV----------YFE-Nd---dKvPYvslsktv-qdmsigTHKI----N--------QM----GVGRAEHMK 551
gi 552842624  505 AAAAELRAG-----------EL--------R-EKeaaqdgl-egmslgGEAA----A-------GRKrgreDAYLAEDLD 552
gi 303272313  494 MEARRARCMT----------LAD-GmtvqvA-QQkalrtgl-stvsleEIPAstsgS-------GVE----AQYLVDHLD 549
gi 146183890  487 YLEIKAKLGLventteeetvITE-Kl---aD-SNldgkvtnktiqslmKEQE----Q-------GNK----LNVGINRLN 546
gi 159476318  575 AYKAVAQAEL----------AAAdL-----K-AReevasgv-ggmsltAEQQ----Qqq----qQQQ----QQYLLDNLD 625
gi 473987008  547 SNSCIEHATG----------IMEdE-----S-APerlskgv-stislgDNRK-------------KD----PKYLLDILG 592
gi 586662587  492 SNSCIEHALG----------VMEeE-----K-AKdkiskgv-ssislsGNDN-------------KP----DKFLVDNLD 537
gi 302829406  886 AYKAVAQAEM----------FAA-El---kA-KDellqagv-gglslgDQQQ----QqtagpqqQQQ----QTYLLEALD 941
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....
gi 121962466  551 SF--DTSFLteKK----------------LVQ-LPPQLQPVQAKPIFFDLAFNS 585
gi 514690161  540 TL--DTSAAvlKRp---------------LLQ-FPPEFQAMSCKPLFFDMGSSH 575
gi 575484802  552 VFfqPSEGVi------------------pVVQsIPPAFEPVSFKPMFYDLAYlg 587
gi 552842624  553 AW--ESFVGpgKGqa-------------rICR-MPPALRTVPFRPIFLDTALNY 590
gi 303272313  550 QY--KSAVLgkGAnk------------vhILP-MPPRMNSVGVRPIMLDVAgde 588
gi 146183890  547 SI--P------------------------IFA-LPPKPLLAGCKPIQFDLvdey 573
gi 159476318  626 KW--ESFAGgaAAtaaaga----akapprLYN-APYEYGAIAVRPIMLDTASNC 672
gi 473987008  593 SY--ESALGeqSAkap-----------crISQ-FPPPFQPVPCNPIVLDMAYNA 632
gi 586662587  538 AY--ESAVGeaDSkgp-----------paIAK-FPPAFQAVVCNPIVLDIAFNS 577
gi 302829406  942 KW--ESFAGgpTAaagtgagasgakapprLHK-APYGFMAIPVRPIMLDTASNC 992
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