2A5Y,3CRD,3YGS


Conserved Protein Domain Family
CARD

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smart00114: CARD 
Click on image for an interactive view with Cn3D
Caspase recruitment domain
Motif contained in proteins involved in apoptotic signalling. Mediates homodimerisation. Structure consists of six antiparallel helices arranged in a topology homologue to the DEATH and the DED domain.
Statistics
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PSSM-Id: 128424
View PSSM: smart00114
Aligned: 14 rows
Threshold Bit Score: 69.674
Threshold Setting Gi: 7767041
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2A5Y_B         2 LCEIECRALSTAHTRLIHDFEP-R---DALTYLEGKNIFTEDHSELISKMSTRLER---IANFLRIYRRQASELGPLIDF 74
gi 17539470    2 MRQDRRSLLERNIMMFSSHLKV-D---EILEVLIAKQVLNSDNGDMINSCGTVREKr--REIVKAVQRRGDVAFDAFYDA 75
gi 3978244   439 keSNDLLLIRKNRMALFQHLTC-Vi--PILDSLLTAGIINEQEHDVIKQKTQTSLQa--RELIDTILVKGNIAATVFRNS 513
gi 193787038   1 MAE---GNHRKKPLKVLESLGK-DfltGVLDNLVEQNVLNWKEEEKKKYYDAKTEDk-vRVMADSMQEKQRMAGQMLLQT 75
gi 148227868   1 MTA-QLNKVRRAIIDGCNPAMI-S---DLLDDLREKNVLVDSEVEHIKESNNTNRDr-cRAMIDSVKKKGDDPSNILLES 74
gi 1336027     1 MDEADRRLLRRCRLRLVEELQV-D---QLWDVLLSRELFRPHMIEDIQRAGSGSRRdqaRQLIIDLETRGSQALPLFISC 76
gi 476218      1 MAVRAKRKQFINSVSIGTINGLlD---ELLEKRVLNQEEMDKIKLANITAMDKARDl--CDHVSKKGPQASQIFITYIC- 74
gi 39995059   32 MHPHHQETLKKNRVVLAKQLLL-S---ELLEHLLEKDIITLEMRELIQAKVGSFSQn--VELLNLLPKRGPQAFDAFCEA 105
gi 149037998   4 MQERPSETIDRERKRLVETLQA-Ds-gLLLDALVARGVLTGPEYEALDALPDAERRv--RRLLLLVQSKGEAACQELLRC 79
gi 81170715   69 STSVKKDNHKKKTVKMLEYLGK-DvlhGVFNYLAKHDVLTLKEEEKKKYYDAKIEDk-aLILVDSLRKNRVAHQMFTQTL 146
                         90
                 ....*....|....*.
2A5Y_B        75 FNyNn-QSHLADFLED 89
gi 17539470   76 LR-StgHEGLAEVLEP 90
gi 3978244   514 LQ-Ea-EAVLYEHLFV 527
gi 193787038  76 FF-Ni-DQISPNKKAH 89
gi 148227868  75 LV-Kn-HKTLAKSLGL 88
gi 1336027    77 LE-DtgQDMLASFLRT 91
gi 476218     75 ---Ne-DCYLAGILEL 86
gi 39995059  106 LR-EtkQGHLEDMLLT 120
gi 149037998  80 AQ-Qt--VSMPDPAWD 92
gi 81170715  147 LN-M--DQKITSVKPL 159
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