1HIB,2MIB,2KKI,2IRT


Conserved Protein Domain Family
IL1

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smart00125: IL1 
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Interleukin-1 homologues
Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.
Statistics
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PSSM-Id: 128430
View PSSM: smart00125
Aligned: 39 rows
Threshold Bit Score: 174.105
Threshold Setting Gi: 1170529
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1HIB_A         3 VRSLNCGLRDS-QQKSLVMSGPYELKALHLQgqDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKdDKPTLQ 81
gi 6016355   129 VIHQECILNDAlNQSIIRDMSGPYLMAATLN--NLEEAVKFDMVAYVSEE-DSQLPVTLRISKTQLFVSAQNE-DEPVLL 204
gi 40950189  129 VIHQECILNDAlNQSIIRDMSGPYLTAATLN--NLEEAVKFDMVAYVSEE-DSQLPVTLRISKTQLFVSAQNE-DEPVLL 204
gi 6166228   129 IVNHQCTLNDAlNQSVIRDTSGQYLATAALN--NLDDAVKFDMGAYTSEE-DSQLPVTLRISKTRLFVSAQNE-DEPVLL 204
gi 27806577  129 VIHQECILNDAlNQSIIRDMSGPYLTATTLN--NLEEAVKFDMVAYVSEE-DSQLPVTLRISKTQLFVSAQNE-DEPVLL 204
gi 47522878  129 VINHQCILNDArNQSIIRDPSGQYLMAAVLN--NLDEAVKFDMAAYTS-NDDSQLPVTLRISETRLFVSAQNE-DEPVLL 204
gi 57526783  129 VIHQECILNDAlNQSIIRDMSGPYMTAATLN--NLEEAVKFDMVAYVSEE-DSQLPVTLRISKTQLFVSAQNE-DEPVLH 204
gi 164623    129 VINHQCILNDArNQSIIRDPSGQYLMAAVLN--NLDEAVKFDMAAYTS-NDDSQLPVTLRISETRLFVSAQNE-DEPVLL 204
gi 8393593   131 IVKQEFIMNDSlNQNIYVDMDRIHLKAASLN--DLQLEVKFDMYAYSSGGDDSKYPVTLKVSNTQLFVSAQGE-DKPVLL 207
gi 156119336 129 IIKQEFTLNDAlNQSLVRDTSDQYLRAAPLQ--NLGDAVKFDMGVYMTSE-DSILPVTLRISQTPLFVSAQNE-DEPVLL 204
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
1HIB_A        82 LESVDPKNYPK-KKMEKRFVFNKIeINNKLEFESAQFPNWYISTSQAENmpVFLGGTKGGqdITDFTMQ 149
gi 6016355   205 KEMPETPKIIK-DETNLLFFWEKH--GSMDYFKSVAHPKLFIATKQEKL--VHMASGPPS--ITDFQIL 266
gi 40950189  205 KEMPETPKIIK-DETNLLFFWEKH--GSMDYFKSVAHPKLFIATKQEKL--VHMASGPPS--VTDFQIL 266
gi 6166228   205 KEMPDTPKTIK-DETNLLFFWERH--GSKNYFKSVAHPKLFIATKQGKL--VHMARGQPS--ITDFQIL 266
gi 27806577  205 KEMPETPKIIK-DETNLLFFWEKH--GSMDYFKSVAHPKLFIATKQEKL--VHMASGPPS--ITDFQIL 266
gi 47522878  205 KELPETPKTIK-DETSLLFFWEKH--GNMDYFKSAAHPKLFIATRQEKL--VHMAPGLPS--VTDFQIL 266
gi 57526783  205 KEMPETPKIIK-DETNLLFFWEKH--GSMDYFKSVAHPKLFIATKQEKL--VHMASGPPS--ITDFLIL 266
gi 164623    205 KELPETPKTIK-DETSLLFFWEKH--GNMDYFKSAAHPKLLIATRQEKL--VHMARGLPS--VTDFQIL 266
gi 8393593   208 KEIPETPKLITgSETDLIFFWEK--INSKNYFTSAAFPELLIATKEQSQ--VHLARGLPS--MIDFQIS 270
gi 156119336 205 KEMPETPRIITdSESDILFFWETQ--GNKNYFKSAANPQLFIATKPEHL--VHMARGLPS--MTDFQIS 267
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