2F83,2F83,2F83,2F83


Conserved Protein Domain Family
APPLE

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smart00223: APPLE 
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APPLE domain
Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple 3 mediates binding to platelets. Factor XI apple 1 binds high-molecular-mass kininogen. Apple 4 in factor XI mediates dimer formation and binds to factor XIIa. Mutations in apple 4 cause factor XI deficiency, an inherited bleeding disorder.
Statistics
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PSSM-Id: 128519
View PSSM: smart00223
Aligned: 19 rows
Threshold Bit Score: 64.3245
Threshold Setting Gi: 6225677
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2F83_A        20 CVTQlLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPS----E----DptrwfT-----CVLKDSVTETL 86
gi 148703597 336 CHSKiYSGVDFEGEELNVTFVQGADVCQETCTKTIRCQFFIYSLLPQD----C----Kee-gcK-----CSLRLSTDGSP 401
gi 158258685 111 CHRDiYKGVDMRGVNFNVSKVSSVEECQKRCTNNIRCQFFSYATQTFH----KaeyrN-----N-----CLLKYSPGGTP 176
gi 3258649   237 CHSSfYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQAS----C----Neg-kgK-----CYLKLSSNGSP 302
gi 180352    110 CNKDiYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPslehR----N-----I-----CLLKHTQTGTP 175
gi 2706495    61 CAQQ-FPNVDFNGDDIQTIYGIQPGECCTRCSETAGCKAYTFVNSNPG----Q----P-----A-----CYLK---SGTG 118
gi 2706495   197 CSKQ-LTDKDYYGNDIKTVYVSLPSLCCDACASTAGCKAYTYINNNPG----Q----P-----V-----CYLK---SAAG 254
gi 71988420   26 ileT-LKSVNSTASLIIRKSVDSLSQCTRFCSSVPNCTHFTFSNAEPI----E----K-----KnggfnCHLH---SKSP 88
2F83_A       110 CNKDiYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPslehR----N-----I-----CLLKHTQTGTP 175
2F83_A       291 CHSSfYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQAS----C----Neg-kgK-----CYLKLSSNGSP 356
                         90
                 ....*....|....*....
2F83_A        87 PRVNR-T-AAISGysFKQC 103
gi 148703597 402 TRITYgM-QGSSGysLRLC 419
gi 158258685 177 TAIKVlS-NVESGfsLKPC 194
gi 3258649   303 TKILHgR-GGISGytLRLC 320
gi 180352    176 TRITKlD-KVVSGfsLKSC 193
gi 2706495   119 TRTPS-V-GAVSG--ILtg 133
gi 2706495   255 TATTK-I-GAVSG--TLN- 268
gi 71988420   89 VLTTS-G-SRTVG--TKTC 103
2F83_A       176 TRITKlD-KVVSGfsLKSC 193
2F83_A       357 TKILH-GrGGISGytLRLC 374
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