1ZIV


Conserved Protein Domain Family
CysPc

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smart00230: CysPc 
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Calpain-like thiol protease family.
Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit).
Statistics
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PSSM-Id: 128526
View PSSM: smart00230
Aligned: 14 rows
Threshold Bit Score: 366.651
Threshold Setting Gi: 68052402
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIV_A         21 FEQMRQECLQRGTLFEDADFPASN---SSLFYSERPQ-----I------PFVWKRPGEIVKN-------PEFILGGAT-R 78
gi 13959310    13 YQELKQECMKDGRLFCDPTFLPEN---DSLFFNRLLP-----G------KVVWKRPQDISDD-------PHLIVGNIS-N 70
gi 74966040   123 YSNIISYCKSSNSPFIDDSFLHNKksiGSLQFTKNGV-----KrheepdFLNWLRPSQMFTKdg---rsSPWSVLNNPrP 194
gi 68052402   122 WKAEPSLTEFETGTNGDVLFTDKP----DLHLSNLQR-----Di-----FAGWKRPHELLSGqvddagmPLNPVMTVSgN 187
gi 119612951   61 FEQLHKKCLEKKVLYVDPEFPPDE---TSLFYSQKFP-----I------QFVWKRPPEICEN-------PRFIIDGAN-R 118
gi 45384280    35 YEALKQECIESGTLFRDPQFPAGP---TALGFKELGP-----Yssk-trGVEWKRPSELVDD-------PQFIVGGAT-R 97
gi 54035686    15 YEKLRKICIKKKQPFVDTLFPPTN---QSLFLEQRQS-----S------DIVWKRPGELHPD-------PHLFVEGAS-P 72
gi 2529435     13 YSALRQDCRRRKVLFEDPLFPATD---DSLYYKGTPG-----P------AVRWKRPKGICED-------PRLFVDGIS-S 70
gi 256083119  841 YETLVKRLKTERTLWEDPDFPAND---KAIGNLPDFR-----E------RIEWKRPHEINPN-------AKFFAGGAS-R 898
gi 281361186 1000 WQNIIQYCRDNSELFVDDSFPPAP---KSLYYNPASGagegnP------VVQWRRPHEINCDgg---ayPPWAVFRTPlP 1067
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIV_A         79 TDICQG-ELGDCWLLAAIASLTLNQK------ALARVIP--QDQSFG----P----GYAGIFHFQFWQHSEWLDVVIDDR 141
gi 13959310    71 HQLIQG-RLGNKAMISAFSCLAVQES------HWTKAIPnhKDQEWDprkpE----KYAGIFHFRFWHFGEWTEVVIDDL 139
gi 74966040   195 SDIEQGtLVGDCWLMSAMALIAERPD------VLDDIIP---KKQYS----------HYGVYQIKLCVEGKWEVIIVDDF 255
gi 68052402   188 TDLVQD-VLTDCSVVASLCATTSRSErglddtLLPIVYPciHNSMKSd---I----SPSGKYIFRFYFNGCFRKVVIDDR 259
gi 119612951  119 TDICQG-ELGDCWFLAAIACLTLNQH------LLFRVIP--HDQSFI----E----NYAGIFHFQFWRYGEWVDVVIDDC 181
gi 45384280    98 TDICQG-ALGDCWLLAAIGSLTLNEE------LLHRVVP--HGQSFQ----E----DYAGIFHFQIWQFGEWVDVVVDDL 160
gi 54035686    73 NDVTQG-ILGNCWFVSACSALTHNFK------LLAQVIPdaDDQEWSt--kH----AYAGIFRFRFWRFGKWVEVVIDDL 139
gi 2529435     71 HDLHQG-QVGNCWFVAACSSLASRES------LWQKVIPdwKEQEWD----PrkaqAYAGIFHFHFWRLG-MVDVVIDER 138
gi 256083119  899 FDIEQG-ALGDCWLLAVVASISGYPQ------LFDQVVP--KDQELKg---P----EYVGVVRFRFWRFGHWVEVLIDDR 962
gi 281361186 1068 SDICQG-VLGNCWLLSALAVLAERED------LVKEVLV---TKEIC----------GQGAYQVRLCKDGKWTTVLVDDL 1127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIV_A        142 LPTFRDR--LVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKE-----A--------PE 206
gi 13959310   140 LPTINGD--LVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIMDFTGTLAEIIDMQK-----GrytdlveeKY 212
gi 74966040   256 FPCYSKTn-SIAMAVGRRNQLWVPLIEKAMAKVLGSYSKLHGASLAQGLSMLTGASCVNYNCPP-----Ipss--vddVD 327
gi 68052402   260 LPSSKTSrsLYMIDRNHRNFMWPALVEKAYLKLRGGYEFPGSNSGTDLWV-LTGWIPEQVFLHS-----Dev-----tAD 328
gi 119612951  182 LPTYNNQ--LVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRD-----A--------PS 246
gi 45384280   161 LPTKDGE--LLFVHSAECTEFWSALLEKAYAKLNGCYESLSGGSTTEGFEDFTGGVAEMYDLKR-----A--------PR 225
gi 54035686   140 LPTRDGK--LLFARSKTPNEFWSALLEKAFAKLYGCYENLVGGHLSDALQDVSGGVAETLHVRK-----FlkddpndtEL 212
gi 2529435    139 LPTVNNQ--LIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTE-----GdfandetkRN 211
gi 256083119  963 LPVRQGRntLVFMHSNDPTEFWSALLEKAYAKLNGCYAHLSGGSQSEAMEDLTGGICLSLELNQ-----Ke------rPS 1031
gi 281361186 1128 LPCDKRG--HLVYSQAKRKQLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQAsslpmPs-------ED 1198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIV_A        207 NFYEILEKALKRG-----SLLGCFIDTRS------------------------------------------------AAE 233
gi 13959310   213 KLFGELYKTFTKG-----GLICCSIESPS------------------------------------------------QEE 239
gi 74966040   328 TFWAQLVSSKESG-----FLMCCHCGAFEn-----------------------------------------------VVA 355
gi 68052402   329 QIWSDLFKSFHSG------DVLLTIGTGK-------------------------------------------------LT 353
gi 119612951  247 DMYKIMKKAIERG-----SLMGCSIDDGTnmtygtspsglnmgeliarmvrnmdnsllqdsdldprgsderptrtiiPVQ 321
gi 45384280   226 NMGHIIRKALERG-----SLLGCSIDITS------------------------------------------------AFD 252
gi 54035686   213 KLFNDLKTAFDKG-----ALVVAAIAART------------------------------------------------KEE 239
gi 2529435    212 QLFERMLKVHSRG-----GLISASIKAVT------------------------------------------------AAD 238
gi 256083119 1032 DLIDQLKIYAQRC-----CLMGCSIDSS---------------------------------------------------V 1055
gi 281361186 1199 ELDKDLIWAQLLSsrcvrFLMGASCGGGNm-----------------------------------------------KVD 1231
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZIV_A        234 SEARTPFGLIKGHAYSVTGIDQVSFRgqR----------------I--ELIRIRNPWG-QVEWNGSWSDSSPEWRSVGPA 294
gi 13959310   240 QEVETDWGLLKGYTYTMTDIRKLRLG--Erlvev------fstekL--YMVRLRNPLG-RQEWSGPWSEISEEWQQLTVT 308
gi 74966040   356 EAEFKAMGLLTNHAYSILDVIYEQGY--R--------------------LLRIRNPWG-QFVWNGKWSDGWPGWP--IGM 410
gi 68052402   354 EREQKELGLVSEHDYAILDMKELKGR--R--------------------QFLIKNPWA---GTDAVYPALFADPG----- 403
gi 119612951  322 YETRMACGLVRGHAYSVTGLDEVPFK--G----------------EkvKLVRLRNPWG-QVEWNGSWSDRWKDWSFVDKD 382
gi 45384280   253 MEAVTFKKLVKGHAYSVTAFKDVNYR--G----------------QqeQLIRIRNPWG-QVEWTGAWSDGSSEWDNIDPS 313
gi 54035686   240 IEESLDCGLVKGHAYAVSAVCTIDVT--NpnersftsfimgskrkQ--NLIRLQNPWG-EKEWNGAWSDDSPEWQNVSAS 314
gi 2529435    239 MEARLACGLVKGHAYAVTDVRKVRLG--Hgllaf------fksekL--DMIRLRNPWG-EREWNGPWSDTSEEWQKVSKS 307
gi 256083119 1056 MEQKMDNGLIGSHAYSLTGVYPVNYR--Gr--------------tQ--WLMRLRNPWGdSHEWKGAWCDGSPQWREISEQ 1117
gi 281361186 1232 EEEYQQKGLRPRHAYSVLDVKDIQGH--R--------------------LLKLRNPWG-HYSWRGDWSDDSSLWT---DD 1285
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
1ZIV_A        295 EQKRLCHTAL----DDGEFWMAFKDFKAHFDKVEICNLTPDALEEDA 337
gi 13959310   309 DRKNLGLVMS----DDGEFWMSLEDFCHNFHKLNVCRNVNNPVFGRK 351
gi 74966040   411 KQKFLNQRKD----ETGAFWMDLEDFVARFASVTVCKLRMDWSELRV 453
gi 68052402   404 PFPNSPFLS------PGTFWMDCEMVLQNFENLYL-NWNPGIFAYQE 443
gi 119612951  383 EKARLQHQVT----EDGEFWMSYEDFIYHFTKLEICNLTADALQSDK 425
gi 45384280   314 DREELQLKM-----EDGEFWMSFRDFMREFSRLEICNLTPDALTKDE 355
gi 54035686   315 QLSTMGVQPAnsdsDDGDFWMPWESFVHYFTDISLCQLFNTSVFSFS 361
gi 2529435    308 EREKMGVTVQ----DDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIH 350
gi 256083119 1118 EKKNINLSFT----ADGEFWMSYEDFVTCFSRVEVCHLGLESLEYNQ 1160
gi 281361186 1286 LRDALMPHGA----SEGVFWISFEDVLNYFDCIDICKVRSGWNEVRl 1328
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