Conserved Protein Domain Family
dDENN

?
smart00801: dDENN 
Domain always found downstream of DENN domain, found in a variety of signalling proteins
The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Statistics
?
PSSM-Id: 129037
View PSSM: smart00801
Aligned: 61 rows
Threshold Bit Score: 39.9658
Threshold Setting Gi: 183233271
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075862   833 SQQILVTFLKFF--IKILGS-YRNYL-R---------KphmsrenfgiSKGSGGL-IGSFDFNKFTRQASKVH--GSWIS 896
gi 67475286   570 NCAVRIILFKFI--NVMLNE-YRDYI-G---------Y----------TWIADKE-SVVFSSEEFIYNQPSDR--RDFLK 623
gi 67478584   531 NISIQLCFFKAV--IQLLLN-YKQYI-Gy--------T----------WISNENV-IIHFNDDQFILSHPSEQ--MDFLK 585
gi 293348737  437 NCKIQHITLQLL--VGIFRE-VKNHL-N---------Y----------------E-HRVFNSEEFLKTRAAGD--QQFYK 484
gi 183230601  563 NLKVRLAYFKFL--TKLLEG-YDEFI-N---------Y----------VWVADNE-VFDFDVYSFFLTKSFDC--EPLIK 616
gi 67482247   625 NEYIQLCFVKGI--SLLMKG-YEEHLgI---------M----------KITENDN-VYLF-EDEFIRERNIEE--HNFLK 678
gi 66806517   626 ELKLq-PFVSAI--NNHISGlFDNFK-Rhc------vR----------NVTHQKTiS-VFVKESFMFTEYPEEehHQWID 684
gi 47225464   388 NREIQkISLELM--VNIFRD-ISGHL-N----------------------YE----HWVFNSEDFLKSREPTE--QLFYR 435
gi 47229374   314 NRQIQnIMLELL--VNTFRG-VQDFL-N-------------------------HE-HRVFNSEEFLRTREPAD--QLFYK 361
gi 66828185   706 NESVHrIYSTIQqyTLWL---FKKIE-IqfitvnvfdS----------LEIED------FKKK-FLSTVSDHN--KEFIK 762
                          90
                  ....*....|....*.
gi 19075862   897 SL-CSSQAFAEFIGDR 911
gi 67475286   624 AL-FESQHFSFFLQNf 638
gi 67478584   586 YL-TETQSFKFFCESy 600
gi 293348737  485 QV-LDTYMFHSFLKAR 499
gi 183230601  617 HF-CESGTFLEYIKEQ 631
gi 67482247   679 EM-MKTQNVVYYIENT 693
gi 66806517   685 EF-TKTLMFSMYLDQK 699
gi 47225464   436 KVivlvqstintnlti 451
gi 47229374   362 KVrSHSPRQTRALAEC 377
gi 66828185   763 ML-LDTQHFSHFLHHN 777
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap