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Conserved domains on  [gi|7546459|pdb|1DM5|B]
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Chain B, ANNEXIN XII E105K MUTANT HOMOHEXAMER

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 247-310 5.04e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 97.93  E-value: 5.04e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
1DM5_B        247 YFAERLHHAMKGLGTSDKTLIRILVSRSEIDLANIKETFQAMYGKSLYEFIADDCSGDYKDLLL 310
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLL 64
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 90-153 1.39e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.38  E-value: 1.39e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
1DM5_B         90 AEQLHAAMKGLGTDKNALIDILCTQSNAQIHAIKAAFKLLYKEDLEKEIISETSGNFQRLLVSM 153
Cdd:pfam00191   3 AELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 17-81 7.48e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.45  E-value: 7.48e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
1DM5_B         17 DAETLRKAMKGIGTDEKSITHILATRSNAQRQQIKTDYTTLFGKHLEDELKSELSGNYEAAALAL 81
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 176-237 7.10e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 7.10e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
1DM5_B        176 IYQAGEGQIGTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQAIENEFSGDIKNGLLAI 237
Cdd:pfam00191   5 LLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 247-310 5.04e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 97.93  E-value: 5.04e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
1DM5_B        247 YFAERLHHAMKGLGTSDKTLIRILVSRSEIDLANIKETFQAMYGKSLYEFIADDCSGDYKDLLL 310
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLL 64
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 90-153 1.39e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.38  E-value: 1.39e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
1DM5_B         90 AEQLHAAMKGLGTDKNALIDILCTQSNAQIHAIKAAFKLLYKEDLEKEIISETSGNFQRLLVSM 153
Cdd:pfam00191   3 AELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 17-81 7.48e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.45  E-value: 7.48e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
1DM5_B         17 DAETLRKAMKGIGTDEKSITHILATRSNAQRQQIKTDYTTLFGKHLEDELKSELSGNYEAAALAL 81
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
260-310 7.01e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.60  E-value: 7.01e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
1DM5_B         260 GTSDKTLIRILVSRSEIDLANIKETFQAMYGKSLYEFIADDCSGDYKDLLL 310
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLL 51
ANX smart00335
Annexin repeats;
101-153 9.75e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.22  E-value: 9.75e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
1DM5_B         101 GTDKNALIDILCTQSNAQIHAIKAAFKLLYKEDLEKEIISETSGNFQRLLVSM 153
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
29-81 9.85e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.22  E-value: 9.85e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
1DM5_B          29 GTDEKSITHILATRSNAQRQQIKTDYTTLFGKHLEDELKSELSGNYEAAALAL 81
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 176-237 7.10e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 7.10e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
1DM5_B        176 IYQAGEGQIGTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQAIENEFSGDIKNGLLAI 237
Cdd:pfam00191   5 LLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
185-237 1.25e-14

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 67.05  E-value: 1.25e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
1DM5_B         185 GTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQAIENEFSGDIKNGLLAI 237
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 247-310 5.04e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 97.93  E-value: 5.04e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
1DM5_B        247 YFAERLHHAMKGLGTSDKTLIRILVSRSEIDLANIKETFQAMYGKSLYEFIADDCSGDYKDLLL 310
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLL 64
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 90-153 1.39e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.38  E-value: 1.39e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
1DM5_B         90 AEQLHAAMKGLGTDKNALIDILCTQSNAQIHAIKAAFKLLYKEDLEKEIISETSGNFQRLLVSM 153
Cdd:pfam00191   3 AELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 17-81 7.48e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.45  E-value: 7.48e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
1DM5_B         17 DAETLRKAMKGIGTDEKSITHILATRSNAQRQQIKTDYTTLFGKHLEDELKSELSGNYEAAALAL 81
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
260-310 7.01e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.60  E-value: 7.01e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
1DM5_B         260 GTSDKTLIRILVSRSEIDLANIKETFQAMYGKSLYEFIADDCSGDYKDLLL 310
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLL 51
ANX smart00335
Annexin repeats;
101-153 9.75e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.22  E-value: 9.75e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
1DM5_B         101 GTDKNALIDILCTQSNAQIHAIKAAFKLLYKEDLEKEIISETSGNFQRLLVSM 153
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
29-81 9.85e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.22  E-value: 9.85e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
1DM5_B          29 GTDEKSITHILATRSNAQRQQIKTDYTTLFGKHLEDELKSELSGNYEAAALAL 81
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 176-237 7.10e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 7.10e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
1DM5_B        176 IYQAGEGQIGTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQAIENEFSGDIKNGLLAI 237
Cdd:pfam00191   5 LLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
185-237 1.25e-14

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 67.05  E-value: 1.25e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
1DM5_B         185 GTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQAIENEFSGDIKNGLLAI 237
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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